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The map label for this gene is ptpA [H]

Identifier: 169630002

GI number: 169630002

Start: 2970442

End: 2972670

Strand: Reverse

Name: ptpA [H]

Synonym: MAB_2919c

Alternate gene names: 169630002

Gene position: 2972670-2970442 (Counterclockwise)

Preceding gene: 169630003

Following gene: 169630001

Centisome position: 58.67

GC content: 65.59

Gene sequence:

>2229_bases
GTGACGACATTGCTGAGCGATTCCGATTACGCGCGTGCCGAGCAGATGCTTTTCCCGCACCGGGCCCGGCGCGTGCCGGG
CACCGTGCTGACACCGCAGTGGTTCGCCGACGGTGCCCGATTCTGGTACCGGATCGGAACCCGCTATGTCGCGGTTGATC
CCGGCGTGAAGACTCGTCGCGCCGCCTTCGACCACGATGCGCTGGCTGCGGCACTGTCGGTGGCGGCGGGGCAGGCGGTG
ACCGGCGCCGATCTACCGATACAGGCCGTGCAAATTCGGGCCGACGACACGGTGCTGTTCAGCGCGTTCGGCCGGAATTG
GCGATGGGCGGATCGCGTCTGCACCGAATCCGACGCTGCCGCACCTATTCCGGGCGGGATCCCGTCACCCGATGAGCGGT
GGGATGCGTTCGGCCGCGAGGGCAATATCTGGGTCCGCAGCCGGGCCGATGGCACCGAACATGCCCTCACCGATGACGCT
GAACCCTACTTCGACTACGGTGGCCTGCCGGACACCACCGGCGGACGGGCACTGATGCGTGCCCTGGGCATTCCGGCGCC
GATAATCCTGCACTGGTCGCCCGATTCCACCCGAATCCTGGTTGCGCGCATCGATCAACGCGAGGTACCCGAACTGGTGC
TCGTCGAATCCAGCCCGGCCGACGGTGGCCGCCCGGTGGAACACCGCACCCGCTACTCGATGCCCGGCGAGAACACCGTG
GCCACGATGACCTGGAACGTGCTCGACGTCGAGCAACGCACGATCGTACGGCAGCAGACCGAGCCGACACCGATCATGCA
CAATGTCGCACTCATCTACGCCTGGTGGTCGAGCGCGGACGCCGTTCATTACCTGCACCAATCGCGCGACGCCCGCACGT
TGCAACTGCGTCGGCTCGCCCCGGCGACCGGCGCGGTCACCACGCTCATCACCGACACAGGCCAGACCCGGGTGGACCCG
ACCGTGGTGCTCGGCGACCCGCACATGGTGCGGGTGCTGGACAACGGCGAGATCCTGTGGTGGTCGCAGCGCGACGGTTG
GGGCCACCTGTACCTCTATTCGGCCGACGGCGTCCAGGTCACCCAGATAACCGCCGGGTCGTGGCTGGTGAGCAGCGTGT
TATGGGTCGACGAAAAGGCTCGACAGGTGTACTTCACGGCCAACGGTTTGGTGGAGGCGGACCCGTATCTGCGGCAGCTC
TGCCGAATCGGGCTGGACGGCAACGGGTTTATCCGTCTCACAGATGATGAGCTGGACCATGATGCGGTCAGCCCGCCGCA
GGGCGGCTACCTGGTAGACCGGGCGTCAAGCCCGAGCCTGCCGCCACGCTCGGTGGTACTGGACGGGGATGGTCAAGTGG
TAGTGGAGTTGGAGACGCCCGATACCGATGACCTGAAGATTCTGGGCTGGCAACCGCCGGAGCGGTTCCGGACGACCGCA
TCGGACGGCAGAACCCCGATCTACGGTCTGCTCTGGCGACCGCACGATCTGGACCCGGACCGCACGTACCCGATCATCGA
ACACATCTATCCGGGGCCGCAGCTCTACCGCGCCGGACCGATGTTCAACCCGCCGCACTACGGCGAACCGGAGGCTTTCG
CCGCGCTCGGGTTCGCGGTGGTGGCCATCGACGGTCGTGGAAGCGCGGGGCGCAGCAAGGCATTTCATGACCACTCCTAT
GGGGATCTCGGCAACGCCGGCGCCTTGGATGACCACATCGTCGCGATCCGTGAACTCGGGCAACGGTATCCGTGGCTGGA
CACCGCCCGAGTTGGGATCACCGGACAGTCCGCGGGCGGTTTCGCCGCGGCGCGTGCGGTGCTGCGCTATCCGGACTTCT
ACTCGGTGGCCGTCGCGGTCTCGGGCAATCATGACAACGCCCTCAACCTGGCGATGTGGGCCGAGCACTACCACGGCGAT
CTGAGCGCCGAAGGCAAAGCAGCGATCTCGAACACCACGCTAGCTGCCAACCTGAAAGGCAAGCTGCTGCTTATCCACGG
CGAACTCGACGACAACGCACACCCATACATGACGATGCGGCTGGCCGACGCACTCATCAAGGCGGACAAAGACTTCGACC
TGATCATGATCCCTGGCGCTGAGCACTCGCTGTACGGTTGGCTGCACTACTCACTACGCCGAACCTGGGACTACTTTGTG
CGGCATCTACACGGCACCGAGCCGCCCGGTTACCGACTACAGCCGTTGCTGCTGCCCTCCCTCGGCTGA

Upstream 100 bases:

>100_bases
CACGGCCTCGGATACTGACTGCCGGGGCTCGCTGTGCCGCTGCGGCACAGCGCAAGTCGCTCTTGACTATGCCGCTACGT
CCGAGTGTTGGATGACTGGT

Downstream 100 bases:

>100_bases
CCGGCACACGATCTCACCGGCCCGCTTCAGCACATCCAGCTGCTCCGGGTCGTGCAAATCGGCCATAGCCCGCTCGACCA
CACTGTCCGCGAACCTTTTC

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MTTLLSDSDYARAEQMLFPHRARRVPGTVLTPQWFADGARFWYRIGTRYVAVDPGVKTRRAAFDHDALAAALSVAAGQAV
TGADLPIQAVQIRADDTVLFSAFGRNWRWADRVCTESDAAAPIPGGIPSPDERWDAFGREGNIWVRSRADGTEHALTDDA
EPYFDYGGLPDTTGGRALMRALGIPAPIILHWSPDSTRILVARIDQREVPELVLVESSPADGGRPVEHRTRYSMPGENTV
ATMTWNVLDVEQRTIVRQQTEPTPIMHNVALIYAWWSSADAVHYLHQSRDARTLQLRRLAPATGAVTTLITDTGQTRVDP
TVVLGDPHMVRVLDNGEILWWSQRDGWGHLYLYSADGVQVTQITAGSWLVSSVLWVDEKARQVYFTANGLVEADPYLRQL
CRIGLDGNGFIRLTDDELDHDAVSPPQGGYLVDRASSPSLPPRSVVLDGDGQVVVELETPDTDDLKILGWQPPERFRTTA
SDGRTPIYGLLWRPHDLDPDRTYPIIEHIYPGPQLYRAGPMFNPPHYGEPEAFAALGFAVVAIDGRGSAGRSKAFHDHSY
GDLGNAGALDDHIVAIRELGQRYPWLDTARVGITGQSAGGFAAARAVLRYPDFYSVAVAVSGNHDNALNLAMWAEHYHGD
LSAEGKAAISNTTLAANLKGKLLLIHGELDDNAHPYMTMRLADALIKADKDFDLIMIPGAEHSLYGWLHYSLRRTWDYFV
RHLHGTEPPGYRLQPLLLPSLG

Sequences:

>Translated_742_residues
MTTLLSDSDYARAEQMLFPHRARRVPGTVLTPQWFADGARFWYRIGTRYVAVDPGVKTRRAAFDHDALAAALSVAAGQAV
TGADLPIQAVQIRADDTVLFSAFGRNWRWADRVCTESDAAAPIPGGIPSPDERWDAFGREGNIWVRSRADGTEHALTDDA
EPYFDYGGLPDTTGGRALMRALGIPAPIILHWSPDSTRILVARIDQREVPELVLVESSPADGGRPVEHRTRYSMPGENTV
ATMTWNVLDVEQRTIVRQQTEPTPIMHNVALIYAWWSSADAVHYLHQSRDARTLQLRRLAPATGAVTTLITDTGQTRVDP
TVVLGDPHMVRVLDNGEILWWSQRDGWGHLYLYSADGVQVTQITAGSWLVSSVLWVDEKARQVYFTANGLVEADPYLRQL
CRIGLDGNGFIRLTDDELDHDAVSPPQGGYLVDRASSPSLPPRSVVLDGDGQVVVELETPDTDDLKILGWQPPERFRTTA
SDGRTPIYGLLWRPHDLDPDRTYPIIEHIYPGPQLYRAGPMFNPPHYGEPEAFAALGFAVVAIDGRGSAGRSKAFHDHSY
GDLGNAGALDDHIVAIRELGQRYPWLDTARVGITGQSAGGFAAARAVLRYPDFYSVAVAVSGNHDNALNLAMWAEHYHGD
LSAEGKAAISNTTLAANLKGKLLLIHGELDDNAHPYMTMRLADALIKADKDFDLIMIPGAEHSLYGWLHYSLRRTWDYFV
RHLHGTEPPGYRLQPLLLPSLG
>Mature_741_residues
TTLLSDSDYARAEQMLFPHRARRVPGTVLTPQWFADGARFWYRIGTRYVAVDPGVKTRRAAFDHDALAAALSVAAGQAVT
GADLPIQAVQIRADDTVLFSAFGRNWRWADRVCTESDAAAPIPGGIPSPDERWDAFGREGNIWVRSRADGTEHALTDDAE
PYFDYGGLPDTTGGRALMRALGIPAPIILHWSPDSTRILVARIDQREVPELVLVESSPADGGRPVEHRTRYSMPGENTVA
TMTWNVLDVEQRTIVRQQTEPTPIMHNVALIYAWWSSADAVHYLHQSRDARTLQLRRLAPATGAVTTLITDTGQTRVDPT
VVLGDPHMVRVLDNGEILWWSQRDGWGHLYLYSADGVQVTQITAGSWLVSSVLWVDEKARQVYFTANGLVEADPYLRQLC
RIGLDGNGFIRLTDDELDHDAVSPPQGGYLVDRASSPSLPPRSVVLDGDGQVVVELETPDTDDLKILGWQPPERFRTTAS
DGRTPIYGLLWRPHDLDPDRTYPIIEHIYPGPQLYRAGPMFNPPHYGEPEAFAALGFAVVAIDGRGSAGRSKAFHDHSYG
DLGNAGALDDHIVAIRELGQRYPWLDTARVGITGQSAGGFAAARAVLRYPDFYSVAVAVSGNHDNALNLAMWAEHYHGDL
SAEGKAAISNTTLAANLKGKLLLIHGELDDNAHPYMTMRLADALIKADKDFDLIMIPGAEHSLYGWLHYSLRRTWDYFVR
HLHGTEPPGYRLQPLLLPSLG

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=368, Percent_Identity=30.4347826086957, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI18450280, Length=368, Percent_Identity=30.4347826086957, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI194394146, Length=373, Percent_Identity=28.1501340482574, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI37577091, Length=363, Percent_Identity=27.5482093663912, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI16933540, Length=383, Percent_Identity=23.7597911227154, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI18765694, Length=603, Percent_Identity=20.3980099502488, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508017, Length=242, Percent_Identity=29.3388429752066, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508019, Length=242, Percent_Identity=29.3388429752066, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17564632, Length=214, Percent_Identity=35.0467289719626, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17564634, Length=214, Percent_Identity=35.0467289719626, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324793, Length=644, Percent_Identity=21.583850931677, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45551969, Length=441, Percent_Identity=25.3968253968254, Blast_Score=120, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45550825, Length=441, Percent_Identity=25.3968253968254, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45553511, Length=441, Percent_Identity=25.3968253968254, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17933704, Length=377, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221331178, Length=377, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161083744, Length=377, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24582257, Length=235, Percent_Identity=27.2340425531915, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 81937; Mature: 81806

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLSDSDYARAEQMLFPHRARRVPGTVLTPQWFADGARFWYRIGTRYVAVDPGVKTRR
CCCEECCCCHHHHHHHHCCHHHHCCCCCEECCHHHCCCCEEEEEECCEEEEECCCCCHHH
AAFDHDALAAALSVAAGQAVTGADLPIQAVQIRADDTVLFSAFGRNWRWADRVCTESDAA
HHCCHHHHHHHHHHHCCCEECCCCCCEEEEEEECCCEEEEEECCCCCCCHHHHCCCCCCC
APIPGGIPSPDERWDAFGREGNIWVRSRADGTEHALTDDAEPYFDYGGLPDTTGGRALMR
CCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ALGIPAPIILHWSPDSTRILVARIDQREVPELVLVESSPADGGRPVEHRTRYSMPGENTV
HHCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCCEE
ATMTWNVLDVEQRTIVRQQTEPTPIMHNVALIYAWWSSADAVHYLHQSRDARTLQLRRLA
EEEEEEEEECHHHHHHHCCCCCCCHHCCEEEEEEECCCCCHHHHHHHCCCCCEEEEEECC
PATGAVTTLITDTGQTRVDPTVVLGDPHMVRVLDNGEILWWSQRDGWGHLYLYSADGVQV
CCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECCCEEEEECCCCCEEEEEEECCCEEE
TQITAGSWLVSSVLWVDEKARQVYFTANGLVEADPYLRQLCRIGLDGNGFIRLTDDELDH
EEEECCHHHHHHHHHCCCCCCEEEEEECCCEECCHHHHHHHHCCCCCCCEEEEECCCCCC
DAVSPPQGGYLVDRASSPSLPPRSVVLDGDGQVVVELETPDTDDLKILGWQPPERFRTTA
CCCCCCCCCEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCEEEEECCCHHHHHCCC
SDGRTPIYGLLWRPHDLDPDRTYPIIEHIYPGPQLYRAGPMFNPPHYGEPEAFAALGFAV
CCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCEEECCCCCCCCCCCCCHHHHEEEEEE
VAIDGRGSAGRSKAFHDHSYGDLGNAGALDDHIVAIRELGQRYPWLDTARVGITGQSAGG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FAAARAVLRYPDFYSVAVAVSGNHDNALNLAMWAEHYHGDLSAEGKAAISNTTLAANLKG
HHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEHHHHCCCCCCCCCEEECCCEEEEECCC
KLLLIHGELDDNAHPYMTMRLADALIKADKDFDLIMIPGAEHSLYGWLHYSLRRTWDYFV
EEEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHHH
RHLHGTEPPGYRLQPLLLPSLG
HHHCCCCCCCCEECEEECCCCC
>Mature Secondary Structure 
TTLLSDSDYARAEQMLFPHRARRVPGTVLTPQWFADGARFWYRIGTRYVAVDPGVKTRR
CCEECCCCHHHHHHHHCCHHHHCCCCCEECCHHHCCCCEEEEEECCEEEEECCCCCHHH
AAFDHDALAAALSVAAGQAVTGADLPIQAVQIRADDTVLFSAFGRNWRWADRVCTESDAA
HHCCHHHHHHHHHHHCCCEECCCCCCEEEEEEECCCEEEEEECCCCCCCHHHHCCCCCCC
APIPGGIPSPDERWDAFGREGNIWVRSRADGTEHALTDDAEPYFDYGGLPDTTGGRALMR
CCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ALGIPAPIILHWSPDSTRILVARIDQREVPELVLVESSPADGGRPVEHRTRYSMPGENTV
HHCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCCEE
ATMTWNVLDVEQRTIVRQQTEPTPIMHNVALIYAWWSSADAVHYLHQSRDARTLQLRRLA
EEEEEEEEECHHHHHHHCCCCCCCHHCCEEEEEEECCCCCHHHHHHHCCCCCEEEEEECC
PATGAVTTLITDTGQTRVDPTVVLGDPHMVRVLDNGEILWWSQRDGWGHLYLYSADGVQV
CCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECCCEEEEECCCCCEEEEEEECCCEEE
TQITAGSWLVSSVLWVDEKARQVYFTANGLVEADPYLRQLCRIGLDGNGFIRLTDDELDH
EEEECCHHHHHHHHHCCCCCCEEEEEECCCEECCHHHHHHHHCCCCCCCEEEEECCCCCC
DAVSPPQGGYLVDRASSPSLPPRSVVLDGDGQVVVELETPDTDDLKILGWQPPERFRTTA
CCCCCCCCCEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCEEEEECCCHHHHHCCC
SDGRTPIYGLLWRPHDLDPDRTYPIIEHIYPGPQLYRAGPMFNPPHYGEPEAFAALGFAV
CCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCEEECCCCCCCCCCCCCHHHHEEEEEE
VAIDGRGSAGRSKAFHDHSYGDLGNAGALDDHIVAIRELGQRYPWLDTARVGITGQSAGG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FAAARAVLRYPDFYSVAVAVSGNHDNALNLAMWAEHYHGDLSAEGKAAISNTTLAANLKG
HHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEHHHHCCCCCCCCCEEECCCEEEEECCC
KLLLIHGELDDNAHPYMTMRLADALIKADKDFDLIMIPGAEHSLYGWLHYSLRRTWDYFV
EEEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHHH
RHLHGTEPPGYRLQPLLLPSLG
HHHCCCCCCCCEECEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA