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The map label for this gene is pgl [H]

Identifier: 169629847

GI number: 169629847

Start: 2811773

End: 2812516

Strand: Direct

Name: pgl [H]

Synonym: MAB_2763

Alternate gene names: 169629847

Gene position: 2811773-2812516 (Clockwise)

Preceding gene: 169629846

Following gene: 169629849

Centisome position: 55.49

GC content: 64.78

Gene sequence:

>744_bases
ATGAGTGAGACGATCATCGAAAAGTACGCGGACACGGATGCTTTGGTGACCGCGGCGGGCGATCGGCTGGCATCGGCGAT
CACCGGCGCCCTCGCCGAACGGGGCAAGGCGATGATCGTACTGACCGGCGGCGGCACCGGCATAGCGCTACTCAAGCACC
TACGCGATGTCGCCAGCGGTCTCGACTGGACCAACGTCCACGTGTTTTGGGGCGATGACCGGTACGTCCCCAAGACCGAT
CCGGAACGCAACGCCTGGCAAGCCTGGGAGGCACTGCTGGAGCACGTGAACTTCCCACTGCGCAACATGCATGCCATGCC
CAACAGCGAAAGCGAGTACGGCACCGATCTTGACGCCGCCGCACTGGCATACGAGCAGCTGTTGGCGGCCAATGCCGAGC
CCGGCCAGGATTGCCCGGCATTTGATGTCCATCTGCTGGGCATGGGCGGCGAAGGTCATATCAATTCATTGTTCCCGCAT
ACCGATGCCGTCAAGGAGACGCAGCGGCTCGTCGTGGCGGTGCCCGACTCTCCCAAGCCTCCGCCACAACGGATCACCTT
GACCCTGCCGGCAATTCAGCGCTCACGCGAAGTGTGGCTGGTGGTTTCCGGCGAGGCGAAGGCCGATGCAGTGGCTGCGG
CCGTCGGCGGTGCCGACCCTGTCGATGTGCCCGCGGCCGGCGCCAAGGGCATCGAGCGCACGGTGTGGCTGCTCGATGAG
GCCGCGGCAAGCCAACTGGGCTAA

Upstream 100 bases:

>100_bases
GCAGGGAGACACGCGATTGTTTGGCCGAGGACTTGCGCCGCCTCGACCCCGACGAGATCTACCGCACGGCGCTCGAGGGA
ATCGCGAAGGTGCAATACGT

Downstream 100 bases:

>100_bases
TCGCCGAGACGATCGCCCGCCACCGCGGCGGTGATCGACTTGATGGCCTCCGCGATCGGTAGGCGATCAACATCCTCGGC
GCGCCATTGCAGCATCGTGG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSETIIEKYADTDALVTAAGDRLASAITGALAERGKAMIVLTGGGTGIALLKHLRDVASGLDWTNVHVFWGDDRYVPKTD
PERNAWQAWEALLEHVNFPLRNMHAMPNSESEYGTDLDAAALAYEQLLAANAEPGQDCPAFDVHLLGMGGEGHINSLFPH
TDAVKETQRLVVAVPDSPKPPPQRITLTLPAIQRSREVWLVVSGEAKADAVAAAVGGADPVDVPAAGAKGIERTVWLLDE
AAASQLG

Sequences:

>Translated_247_residues
MSETIIEKYADTDALVTAAGDRLASAITGALAERGKAMIVLTGGGTGIALLKHLRDVASGLDWTNVHVFWGDDRYVPKTD
PERNAWQAWEALLEHVNFPLRNMHAMPNSESEYGTDLDAAALAYEQLLAANAEPGQDCPAFDVHLLGMGGEGHINSLFPH
TDAVKETQRLVVAVPDSPKPPPQRITLTLPAIQRSREVWLVVSGEAKADAVAAAVGGADPVDVPAAGAKGIERTVWLLDE
AAASQLG
>Mature_246_residues
SETIIEKYADTDALVTAAGDRLASAITGALAERGKAMIVLTGGGTGIALLKHLRDVASGLDWTNVHVFWGDDRYVPKTDP
ERNAWQAWEALLEHVNFPLRNMHAMPNSESEYGTDLDAAALAYEQLLAANAEPGQDCPAFDVHLLGMGGEGHINSLFPHT
DAVKETQRLVVAVPDSPKPPPQRITLTLPAIQRSREVWLVVSGEAKADAVAAAVGGADPVDVPAAGAKGIERTVWLLDEA
AASQLG

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=231, Percent_Identity=29.8701298701299, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI6912586, Length=240, Percent_Identity=32.0833333333333, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI115533058, Length=241, Percent_Identity=27.8008298755187, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=241, Percent_Identity=27.8008298755187, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321957, Length=246, Percent_Identity=26.8292682926829, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321687, Length=256, Percent_Identity=26.5625, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324362, Length=206, Percent_Identity=28.1553398058252, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319918, Length=218, Percent_Identity=27.9816513761468, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641119, Length=224, Percent_Identity=35.7142857142857, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26216; Mature: 26085

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETIIEKYADTDALVTAAGDRLASAITGALAERGKAMIVLTGGGTGIALLKHLRDVASG
CCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCC
LDWTNVHVFWGDDRYVPKTDPERNAWQAWEALLEHVNFPLRNMHAMPNSESEYGTDLDAA
CCCCEEEEEECCCEECCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHH
ALAYEQLLAANAEPGQDCPAFDVHLLGMGGEGHINSLFPHTDAVKETQRLVVAVPDSPKP
HHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHCCCEEEEECCCCCCC
PPQRITLTLPAIQRSREVWLVVSGEAKADAVAAAVGGADPVDVPAAGAKGIERTVWLLDE
CCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AAASQLG
HHHHHCC
>Mature Secondary Structure 
SETIIEKYADTDALVTAAGDRLASAITGALAERGKAMIVLTGGGTGIALLKHLRDVASG
CCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCC
LDWTNVHVFWGDDRYVPKTDPERNAWQAWEALLEHVNFPLRNMHAMPNSESEYGTDLDAA
CCCCEEEEEECCCEECCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHH
ALAYEQLLAANAEPGQDCPAFDVHLLGMGGEGHINSLFPHTDAVKETQRLVVAVPDSPKP
HHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHCCCEEEEECCCCCCC
PPQRITLTLPAIQRSREVWLVVSGEAKADAVAAAVGGADPVDVPAAGAKGIERTVWLLDE
CCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AAASQLG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]