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The map label for this gene is mutA [H]

Identifier: 169629796

GI number: 169629796

Start: 2759637

End: 2761460

Strand: Reverse

Name: mutA [H]

Synonym: MAB_2712c

Alternate gene names: 169629796

Gene position: 2761460-2759637 (Counterclockwise)

Preceding gene: 169629798

Following gene: 169629795

Centisome position: 54.5

GC content: 67.93

Gene sequence:

>1824_bases
GTGACTGTTGAGGTGCCCGAAATTCAGCGTGACTTCGCGCGATGGCAGAAGGGCGTCGCCGGCGTGCTGGCGAAATCGAC
CCGCAAAGCGGTCGAGGACCTGCCGGCGGACCCCGAGCGCCTGCTCGACTCGCCCACCTACGACGGAATTGCCATCCGGC
CGTTGTACACCGCGCTTGACGAGCTACCCGAGCCGTCACTACCCGGGCAGTGGCCCTTCGTGCGTGGCGGTGACCCGCGC
CGCGATGTGAACAGCGGGTGGAAGGTGGCCGAGGCGTTCGGCGGTGCCGCCGATCCGGCGCTGGTGAACGAGACCATCCT
CGATGCGCTGGGACAGGGTGCCAGTGCCATCGTGTTGGCAGGCCTGCCACCCGAGGCGGTTGCTCGGGCCTTGCAGGGTG
TCTACCTGGACCTGGCGCCCGTGCAGCTTGAGGCCGGTGCCGAGCTGGCGGCGGTGGCCGAAGCCCTGTTGACCACCCTC
GATGCCTATGAGGGAGACGCCGCTGCCGTGGTGGCCGATTTGGGCGCCGACCCATTGGGCAACGCCTTCGCGGACCGGGC
CGGGATTTCGATCGATGAGACCGTTGCCCTGGCCCGTCGGGCGACCGCGCGGGCCGAACAGGTGCGCGCCATCACGGTCG
ACGGCACCGTCGCACATGAGTCGGGTGCCAGCGACAGCCAGGAACTCGCGGTGGCGGTGGCCGCCGGCGTCGCATATCTG
CGGCTACTGCAGCGGGCGGGCCTGACCGTCGCGGAAGCGCTGGAGCAGATCAGCTTCCGTATCGCCGCAACAGACGATCA
GTTTCTGTCCATCGCCAAGTTCCGGGCGGCGCGGGTGCTGTGGGCCCGGGTCGCCGAAGTTGCCGGTGCACCCGACGCCG
GTGGCGCGGTTATCCACGCGGTGACCTCCGAACCGATGATGGCACAACGTGATCCGTGGGTGAATATGCTGCGTACCACC
CTCGCCGCCTTCGGCGCGGGAGTCGGCGGTGCGGACAGCGTCCGGGTCCGGCGATTCGACGACGCCATCCCGGGTGGTTT
GAGCGCGGTATCTCCCGCCTTCGCTGCCCGCATTGCACGGAACACTCAGCTGCTGCTTATCGAGGAGTCGCATGTCGCGC
GGGTGCTCGATCCCGGCGGCGGCTCGTGGTTCATCGAAGATTTAACGGAAAGCCTTGCGCAGCAGGCATGGTCGCTGTTC
ACCGAGATCGAGGCCGCGGGCGGCTTTGAAGCCGCCACCGAGCTGATCCGGGAACGGATCGCGGCCACCCGCGCCCAGCG
TGCCGACGACATCGCTCATCGGCGTACCTCGGTCACGGGAGTGAACGAGTTCCCCAATCTCGCGGAGGAGCCGCTACCGC
CGCATCCTGGCACGGGTTACCGGTACGCCGCCGACTTCGAGGAACTGCGGGACCGCTCGGATGCCTTCCTGGCATCCTCC
GGCGCCCGGCCGTCGGCGCTGCTACTGCCGTTGGGACCGTTGGCCGAACACAATGTGCGCACCACATTCGCCTCGAACCT
GTTGGCCTCCGGTGGTATCGAAGCCATCAACCCCGGTGTGCTGGACGCGAGTGCTGTCGCCGGCGCGGTGGCCGATGCCG
GAGCCCGTATCGCCGTCATCTGTGGCACCGATGGCCGGTATGCGGCCGAGGCCGGCGCTGTCGTCGACGCGGCGAAGGCA
GCCGGTATCACCGACGTGTATCTCGCGGGACCGGAGAAGGCTGTTGCCGAGGTCGCGGAGGCCTCCCGGCCGGATGGGTA
CCTCACCATGAAAATCAATGCTGTCGAAGCGCTTTCGGCCATGCTGACCACATTGGGAGCGTGA

Upstream 100 bases:

>100_bases
TAATGGGCGGCGTCATTTAGCCTGATGAGTAAGTGTGATAGGCATTTCGGCATGGAGTGCCATATGTGTCGCTCGACGAC
GAGCAGCAGGGAGCAGTTTT

Downstream 100 bases:

>100_bases
CATGACTGACCTCACGGATCTTTCGGAATCCGGCACCATCCTGGGCAGCTTTGCCGATGTACCGCTGCACGGTGACCGCG
TATCCGTCGCCCCGGACACC

Product: methylmalonyl-CoA mutase small subunit MutA

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTVEVPEIQRDFARWQKGVAGVLAKSTRKAVEDLPADPERLLDSPTYDGIAIRPLYTALDELPEPSLPGQWPFVRGGDPR
RDVNSGWKVAEAFGGAADPALVNETILDALGQGASAIVLAGLPPEAVARALQGVYLDLAPVQLEAGAELAAVAEALLTTL
DAYEGDAAAVVADLGADPLGNAFADRAGISIDETVALARRATARAEQVRAITVDGTVAHESGASDSQELAVAVAAGVAYL
RLLQRAGLTVAEALEQISFRIAATDDQFLSIAKFRAARVLWARVAEVAGAPDAGGAVIHAVTSEPMMAQRDPWVNMLRTT
LAAFGAGVGGADSVRVRRFDDAIPGGLSAVSPAFAARIARNTQLLLIEESHVARVLDPGGGSWFIEDLTESLAQQAWSLF
TEIEAAGGFEAATELIRERIAATRAQRADDIAHRRTSVTGVNEFPNLAEEPLPPHPGTGYRYAADFEELRDRSDAFLASS
GARPSALLLPLGPLAEHNVRTTFASNLLASGGIEAINPGVLDASAVAGAVADAGARIAVICGTDGRYAAEAGAVVDAAKA
AGITDVYLAGPEKAVAEVAEASRPDGYLTMKINAVEALSAMLTTLGA

Sequences:

>Translated_607_residues
MTVEVPEIQRDFARWQKGVAGVLAKSTRKAVEDLPADPERLLDSPTYDGIAIRPLYTALDELPEPSLPGQWPFVRGGDPR
RDVNSGWKVAEAFGGAADPALVNETILDALGQGASAIVLAGLPPEAVARALQGVYLDLAPVQLEAGAELAAVAEALLTTL
DAYEGDAAAVVADLGADPLGNAFADRAGISIDETVALARRATARAEQVRAITVDGTVAHESGASDSQELAVAVAAGVAYL
RLLQRAGLTVAEALEQISFRIAATDDQFLSIAKFRAARVLWARVAEVAGAPDAGGAVIHAVTSEPMMAQRDPWVNMLRTT
LAAFGAGVGGADSVRVRRFDDAIPGGLSAVSPAFAARIARNTQLLLIEESHVARVLDPGGGSWFIEDLTESLAQQAWSLF
TEIEAAGGFEAATELIRERIAATRAQRADDIAHRRTSVTGVNEFPNLAEEPLPPHPGTGYRYAADFEELRDRSDAFLASS
GARPSALLLPLGPLAEHNVRTTFASNLLASGGIEAINPGVLDASAVAGAVADAGARIAVICGTDGRYAAEAGAVVDAAKA
AGITDVYLAGPEKAVAEVAEASRPDGYLTMKINAVEALSAMLTTLGA
>Mature_606_residues
TVEVPEIQRDFARWQKGVAGVLAKSTRKAVEDLPADPERLLDSPTYDGIAIRPLYTALDELPEPSLPGQWPFVRGGDPRR
DVNSGWKVAEAFGGAADPALVNETILDALGQGASAIVLAGLPPEAVARALQGVYLDLAPVQLEAGAELAAVAEALLTTLD
AYEGDAAAVVADLGADPLGNAFADRAGISIDETVALARRATARAEQVRAITVDGTVAHESGASDSQELAVAVAAGVAYLR
LLQRAGLTVAEALEQISFRIAATDDQFLSIAKFRAARVLWARVAEVAGAPDAGGAVIHAVTSEPMMAQRDPWVNMLRTTL
AAFGAGVGGADSVRVRRFDDAIPGGLSAVSPAFAARIARNTQLLLIEESHVARVLDPGGGSWFIEDLTESLAQQAWSLFT
EIEAAGGFEAATELIRERIAATRAQRADDIAHRRTSVTGVNEFPNLAEEPLPPHPGTGYRYAADFEELRDRSDAFLASSG
ARPSALLLPLGPLAEHNVRTTFASNLLASGGIEAINPGVLDASAVAGAVADAGARIAVICGTDGRYAAEAGAVVDAAKAA
GITDVYLAGPEKAVAEVAEASRPDGYLTMKINAVEALSAMLTTLGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=449, Percent_Identity=28.0623608017817, Blast_Score=139, Evalue=7e-33,
Organism=Escherichia coli, GI1789284, Length=242, Percent_Identity=33.0578512396694, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25144500, Length=246, Percent_Identity=32.520325203252, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 63022; Mature: 62891

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEVPEIQRDFARWQKGVAGVLAKSTRKAVEDLPADPERLLDSPTYDGIAIRPLYTALD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEHHHHHHHH
ELPEPSLPGQWPFVRGGDPRRDVNSGWKVAEAFGGAADPALVNETILDALGQGASAIVLA
HCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEE
GLPPEAVARALQGVYLDLAPVQLEAGAELAAVAEALLTTLDAYEGDAAAVVADLGADPLG
CCCHHHHHHHHHHHEEEEECEEECCCCHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCC
NAFADRAGISIDETVALARRATARAEQVRAITVDGTVAHESGASDSQELAVAVAAGVAYL
HHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHH
RLLQRAGLTVAEALEQISFRIAATDDQFLSIAKFRAARVLWARVAEVAGAPDAGGAVIHA
HHHHHCCCHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
VTSEPMMAQRDPWVNMLRTTLAAFGAGVGGADSVRVRRFDDAIPGGLSAVSPAFAARIAR
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHC
NTQLLLIEESHVARVLDPGGGSWFIEDLTESLAQQAWSLFTEIEAAGGFEAATELIRERI
CCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AATRAQRADDIAHRRTSVTGVNEFPNLAEEPLPPHPGTGYRYAADFEELRDRSDAFLASS
HHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHCC
GARPSALLLPLGPLAEHNVRTTFASNLLASGGIEAINPGVLDASAVAGAVADAGARIAVI
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
CGTDGRYAAEAGAVVDAAKAAGITDVYLAGPEKAVAEVAEASRPDGYLTMKINAVEALSA
ECCCCCCHHHCCHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHH
MLTTLGA
HHHHHCC
>Mature Secondary Structure 
TVEVPEIQRDFARWQKGVAGVLAKSTRKAVEDLPADPERLLDSPTYDGIAIRPLYTALD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEHHHHHHHH
ELPEPSLPGQWPFVRGGDPRRDVNSGWKVAEAFGGAADPALVNETILDALGQGASAIVLA
HCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEE
GLPPEAVARALQGVYLDLAPVQLEAGAELAAVAEALLTTLDAYEGDAAAVVADLGADPLG
CCCHHHHHHHHHHHEEEEECEEECCCCHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCC
NAFADRAGISIDETVALARRATARAEQVRAITVDGTVAHESGASDSQELAVAVAAGVAYL
HHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHH
RLLQRAGLTVAEALEQISFRIAATDDQFLSIAKFRAARVLWARVAEVAGAPDAGGAVIHA
HHHHHCCCHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
VTSEPMMAQRDPWVNMLRTTLAAFGAGVGGADSVRVRRFDDAIPGGLSAVSPAFAARIAR
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHC
NTQLLLIEESHVARVLDPGGGSWFIEDLTESLAQQAWSLFTEIEAAGGFEAATELIRERI
CCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AATRAQRADDIAHRRTSVTGVNEFPNLAEEPLPPHPGTGYRYAADFEELRDRSDAFLASS
HHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHCC
GARPSALLLPLGPLAEHNVRTTFASNLLASGGIEAINPGVLDASAVAGAVADAGARIAVI
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
CGTDGRYAAEAGAVVDAAKAAGITDVYLAGPEKAVAEVAEASRPDGYLTMKINAVEALSA
ECCCCCCHHHCCHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHH
MLTTLGA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]