| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is mutB [H]
Identifier: 169629795
GI number: 169629795
Start: 2757356
End: 2759635
Strand: Reverse
Name: mutB [H]
Synonym: MAB_2711c
Alternate gene names: 169629795
Gene position: 2759635-2757356 (Counterclockwise)
Preceding gene: 169629796
Following gene: 169629794
Centisome position: 54.46
GC content: 64.82
Gene sequence:
>2280_bases ATGACTGACCTCACGGATCTTTCGGAATCCGGCACCATCCTGGGCAGCTTTGCCGATGTACCGCTGCACGGTGACCGCGT ATCCGTCGCCCCGGACACCGCCGCCGTTCAGACCGCGGTAAGCGAGGCCGCCGCCGCGCACGGATACAGTCCCGAGCAGC TTGATTGGGAGACGCCGGAGGCGATCACCGTCAAGCCGATCTACACGGCCGCCGACCGCGAGGCGGTGCGGGCGCAGGGT TATCCGTTGGATACCTTCCCCGGTCAGGTGCCCTTCCTGCGCGGGCCGTATCCGACGATGTACGTCAATCAGCCGTGGAC CATTCGCCAGTACGCGGGTTTCTCCACGGCCGCCGAGTCCAACGCGTTCTACCGCCGCAACCTGGCGGCGGGCCAAAAGG GCCTGTCCGTGGCATTCGACCTGGCGACCCATCGCGGGTATGACTCGGACCATCCGCGCGTGCAGGGCGATGTGGGCATG GCTGGCGTGGCCATCGACTCCATCCTGGATATGCGTCAGCTGTTCGACGGTATCGACCTGGGTTCGGTGTCGGTGTCGAT GACCATGAACGGCGCGGTGTTGCCGATCCTCGCGTTGTATGTGGTGGCAGCCGAGGAGCAGGGTGTCGGTACGGAGAAGC TTGCCGGGACCATCCAGAACGACATTCTCAAAGAATTCATGGTCCGCAACACCTACATCTATCCGCCGAAGCCGTCGATG CGGATCATCTCCGATATTTTCGCGTACACCAGCGCCAAGATGCCGAAGTTCAACTCCATCTCGATTTCCGGCTATCACAT CCAAGAGGCCGGTGCCACAGCCGATCTGGAGCTGGCATACACGCTGGCCGATGGCGTCGAGTACATCAAGGCAGGCCTGG CCGGAGGGCTGGACATCGACGTCTTCGCCCCGCGTCTGTCGTTCTTCTGGGCCATCGGCATGAACTTCTTCATGGAGGTC GCCAAGCTGCGCGCCGGGCGTCTGCTGTGGAGTGAGCTTGTCGCGCAGTTCGATCCGAAGAGTTCCAAGTCGCAGTCGCT GCGCACGCATTCGCAGACCTCCGGGTGGTCATTGACCGCGCAGGACGTGTTCAACAATGTGGCCCGCACCTGCATCGAGG CCATGGCCGCCACCCAGGGACACACCCAGTCGCTGCATACCAATGCCCTGGACGAGGCGCTGGCGCTGCCCACCGACTTC TCGGCCCGCATTGCCCGCAACACGCAGCTGCTCATCCAGCAGGAGTCGGGCACCTGTCGCCCGATCGACCCGTGGGGCGG CTCGTACTACGTCGAGTGGCTGACTCACCAGCTCGCCTCCCGCGCGCGCGAACATATTCGGGAGGTCACCGAGGCCGGCG GTATGGCGCAGGCCATCGATCAGGGCATCCCGAAGCTTCGTATCGAAGAGGCCGCCGCACGCACCCAGGCGCGCATCGAC TCGGGCCGTCAGCCGGTGATCGGCGTGAACAAATACCAGGTTGCCGAGGACCAGCAGATCGAGGTTCTCAAGGTAGAGAA TTCCCGCGTACGGGCCGAGCAGCTGGCCAAGTTGCAGCAGCTGCGTGCCGAGCGCGATGACGACGCGGTACAGGCAGCCT TGGCCGAGTTGACTCGTGCGGCAGCCGATTCGGGCCGGGCCGGCGAAGACGGGCTGGGTAACAACCTGATGGCGCTGGCC ATCAACGCCGCTCGGCACAAGGCGACCGTCGGGGAGATCTCCGATGCGCTGGAGAAGGTCTATGGCCGGCATCAGGCCGA AATCCGTACCATCAGCGGGGTATACCGCGACGAAGTGGGAAGGGATGGCGCCGTCAGCAGCGTGACGCAAGCAACCGAGC TGGTACAGAAATTCGCCGACGCCGACGGCCGCCGGCCGCGCGTGCTGGTCGCCAAGATGGGGCAGGACGGGCATGATCGC GGACAGAAGGTGATCGCAACGGCGTTCGCCGACATCGGATTCGATGTCGATGTGGGTCCGCTGTTCCAGACTCCGGAGGA AGTCGCGCGACAGGCCGCCGACAACGACGTGCATGTGGTTGGTGTGTCGTCGTTGGCCGCGGGCCACCTCACCCTGGTCC CTGCACTGCGTCAGGCGCTGGCCGAGGTGGGGCGCCCGGACATCATGATCGTGGTGGGCGGCGTGATCCCGCCGGGCGAT TTCGACGAGCTGTACCAGGCGGGCGCCGCGGCCATCTTCCCTCCCGGAACGGTGATCTCGGAGGCCGCAATTGGCCTGTT GCACAAGCTGGCTGAGCGGCTCGGGTACGACCTGACCTGA
Upstream 100 bases:
>100_bases GCCGAGGTCGCGGAGGCCTCCCGGCCGGATGGGTACCTCACCATGAAAATCAATGCTGTCGAAGCGCTTTCGGCCATGCT GACCACATTGGGAGCGTGAC
Downstream 100 bases:
>100_bases TGTCGGCACCTGACAATCTGGCAGCACTGATCCGGTCGGGAGACCGTTCCGGCCTGGCCCGGGCCATCACCTTGGTGGAG TCGACCCGACAAGATCACCG
Product: methylmalonyl-CoA mutase
Products: NA
Alternate protein names: MCM [H]
Number of amino acids: Translated: 759; Mature: 758
Protein sequence:
>759_residues MTDLTDLSESGTILGSFADVPLHGDRVSVAPDTAAVQTAVSEAAAAHGYSPEQLDWETPEAITVKPIYTAADREAVRAQG YPLDTFPGQVPFLRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGM AGVAIDSILDMRQLFDGIDLGSVSVSMTMNGAVLPILALYVVAAEEQGVGTEKLAGTIQNDILKEFMVRNTYIYPPKPSM RIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLAGGLDIDVFAPRLSFFWAIGMNFFMEV AKLRAGRLLWSELVAQFDPKSSKSQSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDF SARIARNTQLLIQQESGTCRPIDPWGGSYYVEWLTHQLASRAREHIREVTEAGGMAQAIDQGIPKLRIEEAAARTQARID SGRQPVIGVNKYQVAEDQQIEVLKVENSRVRAEQLAKLQQLRAERDDDAVQAALAELTRAAADSGRAGEDGLGNNLMALA INAARHKATVGEISDALEKVYGRHQAEIRTISGVYRDEVGRDGAVSSVTQATELVQKFADADGRRPRVLVAKMGQDGHDR GQKVIATAFADIGFDVDVGPLFQTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRQALAEVGRPDIMIVVGGVIPPGD FDELYQAGAAAIFPPGTVISEAAIGLLHKLAERLGYDLT
Sequences:
>Translated_759_residues MTDLTDLSESGTILGSFADVPLHGDRVSVAPDTAAVQTAVSEAAAAHGYSPEQLDWETPEAITVKPIYTAADREAVRAQG YPLDTFPGQVPFLRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGM AGVAIDSILDMRQLFDGIDLGSVSVSMTMNGAVLPILALYVVAAEEQGVGTEKLAGTIQNDILKEFMVRNTYIYPPKPSM RIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLAGGLDIDVFAPRLSFFWAIGMNFFMEV AKLRAGRLLWSELVAQFDPKSSKSQSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDF SARIARNTQLLIQQESGTCRPIDPWGGSYYVEWLTHQLASRAREHIREVTEAGGMAQAIDQGIPKLRIEEAAARTQARID SGRQPVIGVNKYQVAEDQQIEVLKVENSRVRAEQLAKLQQLRAERDDDAVQAALAELTRAAADSGRAGEDGLGNNLMALA INAARHKATVGEISDALEKVYGRHQAEIRTISGVYRDEVGRDGAVSSVTQATELVQKFADADGRRPRVLVAKMGQDGHDR GQKVIATAFADIGFDVDVGPLFQTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRQALAEVGRPDIMIVVGGVIPPGD FDELYQAGAAAIFPPGTVISEAAIGLLHKLAERLGYDLT >Mature_758_residues TDLTDLSESGTILGSFADVPLHGDRVSVAPDTAAVQTAVSEAAAAHGYSPEQLDWETPEAITVKPIYTAADREAVRAQGY PLDTFPGQVPFLRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMA GVAIDSILDMRQLFDGIDLGSVSVSMTMNGAVLPILALYVVAAEEQGVGTEKLAGTIQNDILKEFMVRNTYIYPPKPSMR IISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLAGGLDIDVFAPRLSFFWAIGMNFFMEVA KLRAGRLLWSELVAQFDPKSSKSQSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFS ARIARNTQLLIQQESGTCRPIDPWGGSYYVEWLTHQLASRAREHIREVTEAGGMAQAIDQGIPKLRIEEAAARTQARIDS GRQPVIGVNKYQVAEDQQIEVLKVENSRVRAEQLAKLQQLRAERDDDAVQAALAELTRAAADSGRAGEDGLGNNLMALAI NAARHKATVGEISDALEKVYGRHQAEIRTISGVYRDEVGRDGAVSSVTQATELVQKFADADGRRPRVLVAKMGQDGHDRG QKVIATAFADIGFDVDVGPLFQTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRQALAEVGRPDIMIVVGGVIPPGDF DELYQAGAAAIFPPGTVISEAAIGLLHKLAERLGYDLT
Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]
COG id: COG1884
COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 B12-binding domain [H]
Homologues:
Organism=Homo sapiens, GI156105689, Length=708, Percent_Identity=61.4406779661017, Blast_Score=899, Evalue=0.0, Organism=Escherichia coli, GI1789284, Length=697, Percent_Identity=59.9713055954089, Blast_Score=825, Evalue=0.0, Organism=Caenorhabditis elegans, GI25144500, Length=738, Percent_Identity=61.9241192411924, Blast_Score=935, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006159 - InterPro: IPR016176 - InterPro: IPR014348 - InterPro: IPR006158 - InterPro: IPR006099 - InterPro: IPR006098 [H]
Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]
EC number: =5.4.99.2 [H]
Molecular weight: Translated: 81792; Mature: 81661
Theoretical pI: Translated: 4.86; Mature: 4.86
Prosite motif: PS00544 METMALONYL_COA_MUTASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTDLTDLSESGTILGSFADVPLHGDRVSVAPDTAAVQTAVSEAAAAHGYSPEQLDWETPE CCCCCCCCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC AITVKPIYTAADREAVRAQGYPLDTFPGQVPFLRGPYPTMYVNQPWTIRQYAGFSTAAES EEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCEEEHHHCCCCCHHCC NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDL CCHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCC GSVSVSMTMNGAVLPILALYVVAAEEQGVGTEKLAGTIQNDILKEFMVRNTYIYPPKPSM CCEEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHH RIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLAGGLDID HHHHHHHHHHHCCCCCCCEEEEECEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHH VFAPRLSFFWAIGMNFFMEVAKLRAGRLLWSELVAQFDPKSSKSQSLRTHSQTSGWSLTA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEH QDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLIQQESGTCR HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCC PIDPWGGSYYVEWLTHQLASRAREHIREVTEAGGMAQAIDQGIPKLRIEEAAARTQARID CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHC SGRQPVIGVNKYQVAEDQQIEVLKVENSRVRAEQLAKLQQLRAERDDDAVQAALAELTRA CCCCCEECCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH AADSGRAGEDGLGNNLMALAINAARHKATVGEISDALEKVYGRHQAEIRTISGVYRDEVG HHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC RDGAVSSVTQATELVQKFADADGRRPRVLVAKMGQDGHDRGQKVIATAFADIGFDVDVGP CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC LFQTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRQALAEVGRPDIMIVVGGVIPPGD CCCCHHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC FDELYQAGAAAIFPPGTVISEAAIGLLHKLAERLGYDLT HHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure TDLTDLSESGTILGSFADVPLHGDRVSVAPDTAAVQTAVSEAAAAHGYSPEQLDWETPE CCCCCCCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC AITVKPIYTAADREAVRAQGYPLDTFPGQVPFLRGPYPTMYVNQPWTIRQYAGFSTAAES EEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCEEEHHHCCCCCHHCC NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDL CCHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCC GSVSVSMTMNGAVLPILALYVVAAEEQGVGTEKLAGTIQNDILKEFMVRNTYIYPPKPSM CCEEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHH RIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLAGGLDID HHHHHHHHHHHCCCCCCCEEEEECEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHH VFAPRLSFFWAIGMNFFMEVAKLRAGRLLWSELVAQFDPKSSKSQSLRTHSQTSGWSLTA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEH QDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLIQQESGTCR HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCC PIDPWGGSYYVEWLTHQLASRAREHIREVTEAGGMAQAIDQGIPKLRIEEAAARTQARID CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHC SGRQPVIGVNKYQVAEDQQIEVLKVENSRVRAEQLAKLQQLRAERDDDAVQAALAELTRA CCCCCEECCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH AADSGRAGEDGLGNNLMALAINAARHKATVGEISDALEKVYGRHQAEIRTISGVYRDEVG HHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC RDGAVSSVTQATELVQKFADADGRRPRVLVAKMGQDGHDRGQKVIATAFADIGFDVDVGP CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCC LFQTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRQALAEVGRPDIMIVVGGVIPPGD CCCCHHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC FDELYQAGAAAIFPPGTVISEAAIGLLHKLAERLGYDLT HHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]