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The map label for this gene is hisI [H]

Identifier: 169629748

GI number: 169629748

Start: 2706326

End: 2706676

Strand: Reverse

Name: hisI [H]

Synonym: MAB_2663c

Alternate gene names: 169629748

Gene position: 2706676-2706326 (Counterclockwise)

Preceding gene: 169629749

Following gene: 169629746

Centisome position: 53.42

GC content: 65.81

Gene sequence:

>351_bases
ATGAGCGAACTCGCTCCAGATATCGCCGCCCGCCTGAAGCGCGATGGCGCTGGTTTGGTGACCGCGGTGGTGCAGGAACA
CGGCACGGGCACCGTCCTCATGGTGGCCTGGATGAATGATGAGGCCCTGGCGCTGACGCTGTCGACGCGGAAGGGCACCT
ACTTCTCACGGTCCCGCCAGCGCCTGTGGGTCAAGGGTGAGACATCGGGGCACACCCAGTACGTGCGTTCGGTGCGGCTG
GATTGCGATGGCGACACGCTGGTCCTGGAAGTGGATCAGTCCGGACCCGCGTGCCACACCGGCGCGCACAGTTGCTTTGA
CGCCGGCGAACTCTTGGGCGAGGCGCCCTAA

Upstream 100 bases:

>100_bases
CCGGTGCCGATGCGGTGTTGGCGGCAAGTGTCTTTCACTTCCGCGAGCTGACCATCGGCGAGGTGAAGGCCGCGATGGCA
GCAGAAGGGATCACGGTGCG

Downstream 100 bases:

>100_bases
CTACTTGCGGGCGCGCAGGAACTCCAGAGCCTTGTCCGCGTGTGCGTTCATATTGAGCTCGCTGGCAAAGACTTCCAGAA
TCGTCTTGTCCGTGTCGATG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MSELAPDIAARLKRDGAGLVTAVVQEHGTGTVLMVAWMNDEALALTLSTRKGTYFSRSRQRLWVKGETSGHTQYVRSVRL
DCDGDTLVLEVDQSGPACHTGAHSCFDAGELLGEAP

Sequences:

>Translated_116_residues
MSELAPDIAARLKRDGAGLVTAVVQEHGTGTVLMVAWMNDEALALTLSTRKGTYFSRSRQRLWVKGETSGHTQYVRSVRL
DCDGDTLVLEVDQSGPACHTGAHSCFDAGELLGEAP
>Mature_115_residues
SELAPDIAARLKRDGAGLVTAVVQEHGTGTVLMVAWMNDEALALTLSTRKGTYFSRSRQRLWVKGETSGHTQYVRSVRLD
CDGDTLVLEVDQSGPACHTGAHSCFDAGELLGEAP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=51.685393258427, Blast_Score=97, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=90, Percent_Identity=35.5555555555556, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 12460; Mature: 12329

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELAPDIAARLKRDGAGLVTAVVQEHGTGTVLMVAWMNDEALALTLSTRKGTYFSRSRQ
CCCCCHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEECCCEEEEEEECCCCCEECCCCE
RLWVKGETSGHTQYVRSVRLDCDGDTLVLEVDQSGPACHTGAHSCFDAGELLGEAP
EEEEECCCCCCHHEEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHCHHHHHCCCC
>Mature Secondary Structure 
SELAPDIAARLKRDGAGLVTAVVQEHGTGTVLMVAWMNDEALALTLSTRKGTYFSRSRQ
CCCCHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEECCCEEEEEEECCCCCEECCCCE
RLWVKGETSGHTQYVRSVRLDCDGDTLVLEVDQSGPACHTGAHSCFDAGELLGEAP
EEEEECCCCCCHHEEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA