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The map label for this gene is trpC

Identifier: 169629730

GI number: 169629730

Start: 2685965

End: 2686783

Strand: Reverse

Name: trpC

Synonym: MAB_2645c

Alternate gene names: 169629730

Gene position: 2686783-2685965 (Counterclockwise)

Preceding gene: 169629731

Following gene: 169629729

Centisome position: 53.02

GC content: 66.91

Gene sequence:

>819_bases
ATGAGTTCGGGAACCGTACTCGATTCGATCCTCGATGGCGTGCGCGCTGATGTCGCGGCTCGCGAAGCCGTTGTCGATCT
TGCCACCGTGAAGGCAGCCGCCAAGGCCGCGCCCAAGCCACTCGATGTGATGGCGGCTCTGCGCGAGCCCGGTATCGCCG
TCATCGCCGAGGTCAAGCGTGCCAGCCCGTCGCGCGGCGCGCTGGCGGAGATCAGCGATCCCGCCGAGCTCGCCAAGGCC
TATGAAGACGGGGGAGCCCGCATCATCAGCGTGCTCACCGAGGGGCGGCGGTTCAACGGAAGTCTCGACGACCTGGACTC
CGTGCGTGCCGCGGTGTCGGTTCCCGTGCTGCGCAAGGACTTTGTGATCAGCCCGTATCAGATCCACGAGGCGCGTGCGC
ATGGCGCCGATCTGATCCTGCTGATCGTGGCGGCGCTCGAACAGACGGCGTTGGTCTCGCTGCTTGATCGCACCGAGTCG
CTCGGCATGACCGCCTTGGTCGAAGTGCACACCGAAGAAGAGGCCGATAGGGCTCTGTCCGCCGGAGCCTCGGTCATCGG
CGTGAACGCGCGCGATCTGAAAACTCTTGAAATCGATCGGGATTGCTTCTCTCGCATCGCCCCGGGACTGCCCAGCGGTG
TCATCCGCATCGCCGAGTCGGGGGTCCGCGGGACCGCCGATCTACTCGCCTACGCCGGCGCCGGCGCAGATGCCGTACTG
GTGGGTGAGGGGCTGGTGACCAGCGGAGACCCCCGAGGTGCGGTCGCCGATCTGGTGACCGCGGGCACGCATCCGTCCTG
CCCCAAACCGGCTCGCTAG

Upstream 100 bases:

>100_bases
ATGTGACCCGGTTTCCTTGTGTGGGCCCGCAGCGGCTACCCTTCTGTGAGGTTCGAGTGCGCAGGCGCGGGGGCGCCGCA
AGAAGGGAATTGTCGAGGTC

Downstream 100 bases:

>100_bases
ACGTCATGAAGAACACCGGCCTGCCGCAGATGAGCACTGCGATCGCTGAGCCCACCGCGCACGATCCTGACGCCCGGGGC
CATTTCGGTCCGTACGGTGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSSGTVLDSILDGVRADVAAREAVVDLATVKAAAKAAPKPLDVMAALREPGIAVIAEVKRASPSRGALAEISDPAELAKA
YEDGGARIISVLTEGRRFNGSLDDLDSVRAAVSVPVLRKDFVISPYQIHEARAHGADLILLIVAALEQTALVSLLDRTES
LGMTALVEVHTEEEADRALSAGASVIGVNARDLKTLEIDRDCFSRIAPGLPSGVIRIAESGVRGTADLLAYAGAGADAVL
VGEGLVTSGDPRGAVADLVTAGTHPSCPKPAR

Sequences:

>Translated_272_residues
MSSGTVLDSILDGVRADVAAREAVVDLATVKAAAKAAPKPLDVMAALREPGIAVIAEVKRASPSRGALAEISDPAELAKA
YEDGGARIISVLTEGRRFNGSLDDLDSVRAAVSVPVLRKDFVISPYQIHEARAHGADLILLIVAALEQTALVSLLDRTES
LGMTALVEVHTEEEADRALSAGASVIGVNARDLKTLEIDRDCFSRIAPGLPSGVIRIAESGVRGTADLLAYAGAGADAVL
VGEGLVTSGDPRGAVADLVTAGTHPSCPKPAR
>Mature_271_residues
SSGTVLDSILDGVRADVAAREAVVDLATVKAAAKAAPKPLDVMAALREPGIAVIAEVKRASPSRGALAEISDPAELAKAY
EDGGARIISVLTEGRRFNGSLDDLDSVRAAVSVPVLRKDFVISPYQIHEARAHGADLILLIVAALEQTALVSLLDRTESL
GMTALVEVHTEEEADRALSAGASVIGVNARDLKTLEIDRDCFSRIAPGLPSGVIRIAESGVRGTADLLAYAGAGADAVLV
GEGLVTSGDPRGAVADLVTAGTHPSCPKPAR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=37.0517928286853, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=43.6619718309859, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_MYCA9 (B1MBV4)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703379.1
- ProteinModelPortal:   B1MBV4
- SMR:   B1MBV4
- EnsemblBacteria:   EBMYCT00000005333
- GeneID:   5965154
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2645c
- GeneTree:   EBGT00050000017090
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   MABS561007:MAB_2645C-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27968; Mature: 27837

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGTVLDSILDGVRADVAAREAVVDLATVKAAAKAAPKPLDVMAALREPGIAVIAEVKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEHHHHH
ASPSRGALAEISDPAELAKAYEDGGARIISVLTEGRRFNGSLDDLDSVRAAVSVPVLRKD
CCCCCCCHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHC
FVISPYQIHEARAHGADLILLIVAALEQTALVSLLDRTESLGMTALVEVHTEEEADRALS
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
AGASVIGVNARDLKTLEIDRDCFSRIAPGLPSGVIRIAESGVRGTADLLAYAGAGADAVL
CCCCEEECCCCCCEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVTSGDPRGAVADLVTAGTHPSCPKPAR
ECCCCEECCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSGTVLDSILDGVRADVAAREAVVDLATVKAAAKAAPKPLDVMAALREPGIAVIAEVKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEHHHHH
ASPSRGALAEISDPAELAKAYEDGGARIISVLTEGRRFNGSLDDLDSVRAAVSVPVLRKD
CCCCCCCHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHC
FVISPYQIHEARAHGADLILLIVAALEQTALVSLLDRTESLGMTALVEVHTEEEADRALS
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
AGASVIGVNARDLKTLEIDRDCFSRIAPGLPSGVIRIAESGVRGTADLLAYAGAGADAVL
CCCCEEECCCCCCEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVTSGDPRGAVADLVTAGTHPSCPKPAR
ECCCCEECCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA