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The map label for this gene is lcfB [H]

Identifier: 169629695

GI number: 169629695

Start: 2646811

End: 2648463

Strand: Direct

Name: lcfB [H]

Synonym: MAB_2609

Alternate gene names: 169629695

Gene position: 2646811-2648463 (Clockwise)

Preceding gene: 169629694

Following gene: 169629696

Centisome position: 52.23

GC content: 62.79

Gene sequence:

>1653_bases
ATGGCTGAGACGATCCAGCAACTGGTGCTGGCCCGTGCCACCGACGACAGCATTGGACTCATCTACCGGGGACAAACCTG
GACATGGCGCGCTCATCTGGCCGCGGCCGCGCGCCACGCCGCGGCGCTGATCGGGATTGCCGACCCCACAAGGCCATTGC
ACGTGGGAACCCTCCTTGGGAATACGCCCGCGATGACAACGGCGATGGCGGCAGCGGCGCAGGGCGGATACATCTTGTGC
GCCATCAACAACACGCGCCGTGGCGAAGGTCTGCTACGTGACATCCGGAAGTCCGATGTGCAGGTACTGCTGGTGGACGC
CGAACATCGACCGCTCCTCGACGCGGTGGACCTGCCAGATGTGACGGTGATCGACGTCGACAGTGCCGAGTGGATCGAAC
GGATGAAGACGCCCGGCGAACTGCATCCCTACCGGACTGCCGCCCCCCTTGACCCCTTCATGATGATCTTCACGTCAGGA
ACCAGCGGCGACCCGAAAGCCGTTTTGGTGACACACGCGACGGTGCTCGTTGCCGCCGAATCACTGGTGGAGCGCTTCTC
GCTGTCTGCCGCCGACGTCTGTTACGTATCGATGCCGCTGTTCCATTCGAATGCCGTGCTGGCGGGATGGGCCGTCGCCG
TCGCCGCAGGAGCCGCATTGGCTCCTGCGAAATTCTCCGCGTCGCGATTTCTGGCCGACATCCGCGAGGTCGGCGCCACG
TACATGAACTATGTGGGCAAGCCGCTGGCCTACGTGCTGGCGACCGCAGAACACGCGGACGACGCCGCCAATCCACTGCG
GGTGGCATTCGGAAACGAAGCTTCCGAATCTGATATCGCCGAATTCGCAAGGCGATTCGATGTCACGGTGTACGACGGAT
TCGGTTCGACCGAGAACGCGGTGATCATAACCCGGGAGGAGGGAACGCCGACGGGATCCATCGGCAAGGGTTTCCCCGGC
ATAGCGGTCTACAACCCGGACACGTTGCGCGAATGCGCGGTGGCGCGCTTCGACGCGCACGGCATACTGGCCAACCCCGC
TGATGCGGTCGGCGAGTTGGTGAATACCCAGGGCGCTGGGTTCTTTTCGGGGTACTACAACGACGACGACGCCACCGGCG
AACGCATGCGGCACGGCATGTATTGGTCCGGCGACCTTGCCTACCGCGATGCCGATGGCTGGATCTACTTGGCGGGGCGC
ACGCCGGACTGGATGCGGATCAACGGTGAGAATCTTGCCGCGGCACCGATCGAGCGGGTTCTCCAACGCCACCCCGCGAT
CAGCCAAGCAGCGGTGTACGCGGTTCGTGATGAACATGGTGGCGACGCCGTGATGGCCGCGTTGGTGTTGCGTGCCCCGC
TGACGTACCTGGGCCTGGCCGAGTTTCTTTCCGCCCAGCAAGACCTGCCGCGTATCGGATGGCCACGGTATATCCGGTTG
AGTGAAAATCTCCCCACTACCGCGACCAACAAAATACTGAAACGTGTACTGATTTCCGAAGGTCTCGATATTGCGGACGA
GACATTGTGGTATCGCGCGGAACGCGGTGCGGAATATATCGATTTCGATCCAGTGGGCCATTCGCCGCATCTCATCGCGC
CAAGGCTCCGCAGCATAGGTGCCGCGGCCCCGCCAAGCGAGCCAACAAGGTGA

Upstream 100 bases:

>100_bases
TACCACGGCCAGGAGTGTCACGAGCTCGTCATTGGCCACCAAATAAGTTTCCTGTCAAGGCATCTGAGCATCGAAGCAGT
ATCGCACACCGAAGCACTTC

Downstream 100 bases:

>100_bases
TTCTTGACTATTCCTTGAGGTCATTGAACCACGATGATTTCTGGACTGTTTACCCAGTTCAACGCTGTTATTTTCCGCAT
AAAACGTAAATAAAGCCGAA

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MAETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIADPTRPLHVGTLLGNTPAMTTAMAAAAQGGYILC
AINNTRRGEGLLRDIRKSDVQVLLVDAEHRPLLDAVDLPDVTVIDVDSAEWIERMKTPGELHPYRTAAPLDPFMMIFTSG
TSGDPKAVLVTHATVLVAAESLVERFSLSAADVCYVSMPLFHSNAVLAGWAVAVAAGAALAPAKFSASRFLADIREVGAT
YMNYVGKPLAYVLATAEHADDAANPLRVAFGNEASESDIAEFARRFDVTVYDGFGSTENAVIITREEGTPTGSIGKGFPG
IAVYNPDTLRECAVARFDAHGILANPADAVGELVNTQGAGFFSGYYNDDDATGERMRHGMYWSGDLAYRDADGWIYLAGR
TPDWMRINGENLAAAPIERVLQRHPAISQAAVYAVRDEHGGDAVMAALVLRAPLTYLGLAEFLSAQQDLPRIGWPRYIRL
SENLPTTATNKILKRVLISEGLDIADETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIGAAAPPSEPTR

Sequences:

>Translated_550_residues
MAETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIADPTRPLHVGTLLGNTPAMTTAMAAAAQGGYILC
AINNTRRGEGLLRDIRKSDVQVLLVDAEHRPLLDAVDLPDVTVIDVDSAEWIERMKTPGELHPYRTAAPLDPFMMIFTSG
TSGDPKAVLVTHATVLVAAESLVERFSLSAADVCYVSMPLFHSNAVLAGWAVAVAAGAALAPAKFSASRFLADIREVGAT
YMNYVGKPLAYVLATAEHADDAANPLRVAFGNEASESDIAEFARRFDVTVYDGFGSTENAVIITREEGTPTGSIGKGFPG
IAVYNPDTLRECAVARFDAHGILANPADAVGELVNTQGAGFFSGYYNDDDATGERMRHGMYWSGDLAYRDADGWIYLAGR
TPDWMRINGENLAAAPIERVLQRHPAISQAAVYAVRDEHGGDAVMAALVLRAPLTYLGLAEFLSAQQDLPRIGWPRYIRL
SENLPTTATNKILKRVLISEGLDIADETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIGAAAPPSEPTR
>Mature_549_residues
AETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIADPTRPLHVGTLLGNTPAMTTAMAAAAQGGYILCA
INNTRRGEGLLRDIRKSDVQVLLVDAEHRPLLDAVDLPDVTVIDVDSAEWIERMKTPGELHPYRTAAPLDPFMMIFTSGT
SGDPKAVLVTHATVLVAAESLVERFSLSAADVCYVSMPLFHSNAVLAGWAVAVAAGAALAPAKFSASRFLADIREVGATY
MNYVGKPLAYVLATAEHADDAANPLRVAFGNEASESDIAEFARRFDVTVYDGFGSTENAVIITREEGTPTGSIGKGFPGI
AVYNPDTLRECAVARFDAHGILANPADAVGELVNTQGAGFFSGYYNDDDATGERMRHGMYWSGDLAYRDADGWIYLAGRT
PDWMRINGENLAAAPIERVLQRHPAISQAAVYAVRDEHGGDAVMAALVLRAPLTYLGLAEFLSAQQDLPRIGWPRYIRLS
ENLPTTATNKILKRVLISEGLDIADETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIGAAAPPSEPTR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=562, Percent_Identity=25.9786476868327, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI62865631, Length=520, Percent_Identity=25.3846153846154, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI13325055, Length=520, Percent_Identity=25.3846153846154, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI13325057, Length=467, Percent_Identity=28.2655246252677, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI13236579, Length=370, Percent_Identity=26.7567567567568, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI40807357, Length=402, Percent_Identity=27.8606965174129, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI38524616, Length=377, Percent_Identity=30.2387267904509, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI227499621, Length=546, Percent_Identity=23.8095238095238, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI122937307, Length=512, Percent_Identity=23.4375, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI156151445, Length=358, Percent_Identity=25.4189944134078, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI42544132, Length=483, Percent_Identity=22.1532091097308, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38505220, Length=504, Percent_Identity=23.2142857142857, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI157311624, Length=503, Percent_Identity=22.2664015904573, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI157311622, Length=503, Percent_Identity=22.2664015904573, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI58082049, Length=498, Percent_Identity=22.0883534136546, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI221142682, Length=464, Percent_Identity=26.0775862068966, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI145693145, Length=353, Percent_Identity=28.0453257790368, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1786810, Length=416, Percent_Identity=26.6826923076923, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=23.6263736263736, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1789201, Length=378, Percent_Identity=22.7513227513227, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790505, Length=123, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788595, Length=305, Percent_Identity=24.2622950819672, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534440, Length=510, Percent_Identity=25.4901960784314, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17551278, Length=371, Percent_Identity=27.2237196765499, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=443, Percent_Identity=22.3476297968397, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=356, Percent_Identity=22.752808988764, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=361, Percent_Identity=23.5457063711911, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=396, Percent_Identity=22.979797979798, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=354, Percent_Identity=25.9887005649718, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319515, Length=409, Percent_Identity=23.7163814180929, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319264, Length=407, Percent_Identity=24.5700245700246, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=384, Percent_Identity=26.0416666666667, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573631, Length=504, Percent_Identity=26.984126984127, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI20130353, Length=504, Percent_Identity=26.984126984127, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24583465, Length=554, Percent_Identity=26.8953068592058, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24583463, Length=554, Percent_Identity=26.8953068592058, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281364798, Length=554, Percent_Identity=26.8953068592058, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45552801, Length=547, Percent_Identity=25.5941499085923, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45550496, Length=546, Percent_Identity=25.4578754578755, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18859661, Length=364, Percent_Identity=25.2747252747253, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=379, Percent_Identity=25.065963060686, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581924, Length=358, Percent_Identity=26.536312849162, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 59276; Mature: 59144

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIADPTRPLHVGTLLG
CHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHEEEEECCCCCCCEEEEEECC
NTPAMTTAMAAAAQGGYILCAINNTRRGEGLLRDIRKSDVQVLLVDAEHRPLLDAVDLPD
CCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCC
VTVIDVDSAEWIERMKTPGELHPYRTAAPLDPFMMIFTSGTSGDPKAVLVTHATVLVAAE
EEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHH
SLVERFSLSAADVCYVSMPLFHSNAVLAGWAVAVAAGAALAPAKFSASRFLADIREVGAT
HHHHHHCCCCCCEEEEEECEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
YMNYVGKPLAYVLATAEHADDAANPLRVAFGNEASESDIAEFARRFDVTVYDGFGSTENA
HHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCCCCCCCE
VIITREEGTPTGSIGKGFPGIAVYNPDTLRECAVARFDAHGILANPADAVGELVNTQGAG
EEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCC
FFSGYYNDDDATGERMRHGMYWSGDLAYRDADGWIYLAGRTPDWMRINGENLAAAPIERV
EEECCCCCCCCCHHHHHCCCEECCCEEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHH
LQRHPAISQAAVYAVRDEHGGDAVMAALVLRAPLTYLGLAEFLSAQQDLPRIGWPRYIRL
HHHCCCCCHHEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEE
SENLPTTATNKILKRVLISEGLDIADETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIG
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEECHHHHHCC
AAAPPSEPTR
CCCCCCCCCC
>Mature Secondary Structure 
AETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIADPTRPLHVGTLLG
HHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHEEEEECCCCCCCEEEEEECC
NTPAMTTAMAAAAQGGYILCAINNTRRGEGLLRDIRKSDVQVLLVDAEHRPLLDAVDLPD
CCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCC
VTVIDVDSAEWIERMKTPGELHPYRTAAPLDPFMMIFTSGTSGDPKAVLVTHATVLVAAE
EEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHH
SLVERFSLSAADVCYVSMPLFHSNAVLAGWAVAVAAGAALAPAKFSASRFLADIREVGAT
HHHHHHCCCCCCEEEEEECEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
YMNYVGKPLAYVLATAEHADDAANPLRVAFGNEASESDIAEFARRFDVTVYDGFGSTENA
HHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCCCCCCCE
VIITREEGTPTGSIGKGFPGIAVYNPDTLRECAVARFDAHGILANPADAVGELVNTQGAG
EEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCC
FFSGYYNDDDATGERMRHGMYWSGDLAYRDADGWIYLAGRTPDWMRINGENLAAAPIERV
EEECCCCCCCCCHHHHHCCCEECCCEEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHH
LQRHPAISQAAVYAVRDEHGGDAVMAALVLRAPLTYLGLAEFLSAQQDLPRIGWPRYIRL
HHHCCCCCHHEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEE
SENLPTTATNKILKRVLISEGLDIADETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIG
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEECHHHHHCC
AAAPPSEPTR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]