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The map label for this gene is pheS [H]

Identifier: 169629420

GI number: 169629420

Start: 2387219

End: 2388274

Strand: Direct

Name: pheS [H]

Synonym: MAB_2334

Alternate gene names: 169629420

Gene position: 2387219-2388274 (Clockwise)

Preceding gene: 169629417

Following gene: 169629421

Centisome position: 47.11

GC content: 64.11

Gene sequence:

>1056_bases
GTGGCCGATCACACCCAGCACCCTTCGGCGGAGTCTTCAGCGGAACTTTTGACAACTGCCGTTGATGCTGCTCGCGCTGC
CTTTGATACCGCCGACAACCTGGATGGCCTCGCGCAGGCGAAGATCGACCATCTCGGAGAAAAGTCGCCGCTGGCGCAGG
CTCGTCAGGCGCTGGGTTCGCTCCCGAAGGACCAGCGGGCCGAGGCCGGCAAGCTCGTCAACGCGGCTCGCACGCAGGCG
CAGCAGGCCTATGACGACAGGCTGGAGACGCTGCGTGCCGAACGCGACGCCGCGGTACTCGTCGCGGAACGCATCGACGT
GACATTGCCCTCGACTAGGCAGCCCCTGGGGGCCCGCCACCCCATCACGATCTTGTCGGAGAACATCGCCGACACCTTCA
TCGCGATGGGATGGGAAGTGGCGGACGGCCCCGAGGTCGAAACCGAGCATTTCAACTTCGATGCCCTGAATTTTCTGCCC
GACCACCCGGCGCGCAGCACGCAGGACACCTTCTACATCGCGCCGGAAGACTCGCGGCAGGTCTTGCGTACACATACCTC
GCCGGTACAAGTCCGCACGCTGTTGGCACGTGAACTGCCGGTCTACGTGATCTCGCTGGGACGCGCCTTCCGTACCGACG
AGATCGACGCCACCCACCTGCCCGCTTTCCATCAGGTGGAAGGGCTCGCCGTGGATCGGGGACTGACCTTGGCCAATCTC
AAGGGCACCCTTGACGCGTTTGCCCGGGCGATGTTCGGGGCGCAGGCGCACACACGGATGCGGCCGCACTACTTCCCATT
CACCGAGCCCTCCGCGGAGGTCGACGTCTGGTTTGAGAACAAGAAGGGTGGTGCGGGCTGGGTCGAATGGGGCGGTTGCG
GCATGGTGAATCCGAATGTTTTACGGGCCAGCGGTATTGACCCCGGCGAGTACAGTGGCTTCGCGTTCGGCATGGGATTG
GAGCGCACCCTGCAGTTCCGCAATGGGCTTCCCGATATGCGCGACATGATCGAGGGCGACGTCCGCTTCAGCTTGCCGTT
CGGAGTGAGTGCCTGA

Upstream 100 bases:

>100_bases
CCAGACACGCGCTCACCGGATGGCTGTGCCCTGACGTCCCGAATGTCCCGACTGACATGACGGGAAGGTGGCTAACCGGC
TTACCCTATGATCGGCATCC

Downstream 100 bases:

>100_bases
TGCGAGTTCCTTACAGCTGGCTGCTTGAGGTGTTGCGGGTCGGTGCCCCGGAGTTCACCGCCAGTGCGGCCGATATCGAA
GAAACCCTGATTCGCATTGG

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MADHTQHPSAESSAELLTTAVDAARAAFDTADNLDGLAQAKIDHLGEKSPLAQARQALGSLPKDQRAEAGKLVNAARTQA
QQAYDDRLETLRAERDAAVLVAERIDVTLPSTRQPLGARHPITILSENIADTFIAMGWEVADGPEVETEHFNFDALNFLP
DHPARSTQDTFYIAPEDSRQVLRTHTSPVQVRTLLARELPVYVISLGRAFRTDEIDATHLPAFHQVEGLAVDRGLTLANL
KGTLDAFARAMFGAQAHTRMRPHYFPFTEPSAEVDVWFENKKGGAGWVEWGGCGMVNPNVLRASGIDPGEYSGFAFGMGL
ERTLQFRNGLPDMRDMIEGDVRFSLPFGVSA

Sequences:

>Translated_351_residues
MADHTQHPSAESSAELLTTAVDAARAAFDTADNLDGLAQAKIDHLGEKSPLAQARQALGSLPKDQRAEAGKLVNAARTQA
QQAYDDRLETLRAERDAAVLVAERIDVTLPSTRQPLGARHPITILSENIADTFIAMGWEVADGPEVETEHFNFDALNFLP
DHPARSTQDTFYIAPEDSRQVLRTHTSPVQVRTLLARELPVYVISLGRAFRTDEIDATHLPAFHQVEGLAVDRGLTLANL
KGTLDAFARAMFGAQAHTRMRPHYFPFTEPSAEVDVWFENKKGGAGWVEWGGCGMVNPNVLRASGIDPGEYSGFAFGMGL
ERTLQFRNGLPDMRDMIEGDVRFSLPFGVSA
>Mature_350_residues
ADHTQHPSAESSAELLTTAVDAARAAFDTADNLDGLAQAKIDHLGEKSPLAQARQALGSLPKDQRAEAGKLVNAARTQAQ
QAYDDRLETLRAERDAAVLVAERIDVTLPSTRQPLGARHPITILSENIADTFIAMGWEVADGPEVETEHFNFDALNFLPD
HPARSTQDTFYIAPEDSRQVLRTHTSPVQVRTLLARELPVYVISLGRAFRTDEIDATHLPAFHQVEGLAVDRGLTLANLK
GTLDAFARAMFGAQAHTRMRPHYFPFTEPSAEVDVWFENKKGGAGWVEWGGCGMVNPNVLRASGIDPGEYSGFAFGMGLE
RTLQFRNGLPDMRDMIEGDVRFSLPFGVSA

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758340, Length=273, Percent_Identity=31.5018315018315, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI5729820, Length=276, Percent_Identity=28.9855072463768, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788007, Length=331, Percent_Identity=46.2235649546828, Blast_Score=284, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17508957, Length=273, Percent_Identity=31.8681318681319, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI32563657, Length=273, Percent_Identity=31.8681318681319, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI32566635, Length=285, Percent_Identity=30.1754385964912, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321087, Length=262, Percent_Identity=33.206106870229, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6325304, Length=85, Percent_Identity=40, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18858079, Length=271, Percent_Identity=32.8413284132841, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 38418; Mature: 38287

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHTQHPSAESSAELLTTAVDAARAAFDTADNLDGLAQAKIDHLGEKSPLAQARQALGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
LPKDQRAEAGKLVNAARTQAQQAYDDRLETLRAERDAAVLVAERIDVTLPSTRQPLGARH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCEECCCCCCCCCCCC
PITILSENIADTFIAMGWEVADGPEVETEHFNFDALNFLPDHPARSTQDTFYIAPEDSRQ
CHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
VLRTHTSPVQVRTLLARELPVYVISLGRAFRTDEIDATHLPAFHQVEGLAVDRGLTLANL
HHHHCCCHHHHHHHHHHHCCEEEEECCCHHCCCCCCCCCCCHHHHHCCEEECCCCEEEHH
KGTLDAFARAMFGAQAHTRMRPHYFPFTEPSAEVDVWFENKKGGAGWVEWGGCGMVNPNV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCE
LRASGIDPGEYSGFAFGMGLERTLQFRNGLPDMRDMIEGDVRFSLPFGVSA
EEECCCCCCCCCCEEECCCHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
ADHTQHPSAESSAELLTTAVDAARAAFDTADNLDGLAQAKIDHLGEKSPLAQARQALGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
LPKDQRAEAGKLVNAARTQAQQAYDDRLETLRAERDAAVLVAERIDVTLPSTRQPLGARH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCEECCCCCCCCCCCC
PITILSENIADTFIAMGWEVADGPEVETEHFNFDALNFLPDHPARSTQDTFYIAPEDSRQ
CHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
VLRTHTSPVQVRTLLARELPVYVISLGRAFRTDEIDATHLPAFHQVEGLAVDRGLTLANL
HHHHCCCHHHHHHHHHHHCCEEEEECCCHHCCCCCCCCCCCHHHHHCCEEECCCCEEEHH
KGTLDAFARAMFGAQAHTRMRPHYFPFTEPSAEVDVWFENKKGGAGWVEWGGCGMVNPNV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCE
LRASGIDPGEYSGFAFGMGLERTLQFRNGLPDMRDMIEGDVRFSLPFGVSA
EEECCCCCCCCCCEEECCCHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA