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The map label for this gene is ermF [H]

Identifier: 169629383

GI number: 169629383

Start: 2345955

End: 2346476

Strand: Direct

Name: ermF [H]

Synonym: MAB_2297

Alternate gene names: 169629383

Gene position: 2345955-2346476 (Clockwise)

Preceding gene: 169629382

Following gene: 169629384

Centisome position: 46.3

GC content: 65.9

Gene sequence:

>522_bases
GTGTCCGGCCAACGGTCGCGACGCCAGTGGGGCTGGTATCCGCTCACTGATGACTGGGCGGCGCGGATCGTCGCCGAATC
CGGTGTTCGCTCAGGGGAGTTCGTTGTGGATCTGGGCGCAGGACACGGCGCGCTGACGGCACATCTGGTTGCCGCTGGTG
CCAGGGTGCTAGCCGTCGAGCTGCATCCGGGGCGGGCTCGACACCTTCGTTCACGGTTTGCCGAGGAAGATGTCCGGATA
GCGGAAGCGGACCTGCTCGCCTTCCGGTGGCCGCGACGGCCATTTCGGGTGGTGGCGAGCCCGCCCTACCAAGTCACCAG
CGCACTGATACGGAGTCTCTTGACGCCGGAATCCCGGCTGCTGGCTGCCGACCTGGTGCTGCAGCGCGGGGCTGTGCACA
AACATGCGAAGCGAGCACCTGTTCGCCATTGGACGCTACGGGCCGGAATCACATTGCCGCGAAGCGCTTTCCATCATCCA
CCGCAGGTGGATTCGTCGGTGCTGGTGATCAGGCGGCGCTGA

Upstream 100 bases:

>100_bases
CCCCGGTCATGGCGACCGGGGCCTTCTTCGTGATCTATCGAAACCAGTTGCATGCCCCGATATCTTTGGAGCATGGGCAT
ATTCATGATGGTGCTGCGTC

Downstream 100 bases:

>100_bases
CCCTGTGACAGACTGCGGGCATGTTGCGTATCGGCCTAACCGGTGGAATCGGTGCGGGGAAGTCCACCGTCTCGCGGACC
CTCGCCGGGTGCGGGGCTTT

Product: methyltransferase

Products: NA

Alternate protein names: Erythromycin resistance protein; Macrolide-lincosamide-streptogramin B resistance protein [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSGQRSRRQWGWYPLTDDWAARIVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRI
AEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHP
PQVDSSVLVIRRR

Sequences:

>Translated_173_residues
MSGQRSRRQWGWYPLTDDWAARIVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRI
AEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHP
PQVDSSVLVIRRR
>Mature_172_residues
SGQRSRRQWGWYPLTDDWAARIVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSRFAEEDVRIA
EADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPP
QVDSSVLVIRRR

Specific function: Involved in erythromycin resistance [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 19343; Mature: 19211

Theoretical pI: Translated: 12.18; Mature: 12.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQRSRRQWGWYPLTDDWAARIVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEE
LHPGRARHLRSRFAEEDVRIAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRL
ECCCHHHHHHHHHHHHHCCHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHHHCCCHHH
LAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR
HHHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
SGQRSRRQWGWYPLTDDWAARIVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVE
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEE
LHPGRARHLRSRFAEEDVRIAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRL
ECCCHHHHHHHHHHHHHCCHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHHHCCCHHH
LAADLVLQRGAVHKHAKRAPVRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR
HHHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Dimethylation [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3023281; 3038844 [H]