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The map label for this gene is coaE [H]

Identifier: 169629384

GI number: 169629384

Start: 2346497

End: 2347684

Strand: Direct

Name: coaE [H]

Synonym: MAB_2298

Alternate gene names: 169629384

Gene position: 2346497-2347684 (Clockwise)

Preceding gene: 169629383

Following gene: 169629386

Centisome position: 46.31

GC content: 65.15

Gene sequence:

>1188_bases
ATGTTGCGTATCGGCCTAACCGGTGGAATCGGTGCGGGGAAGTCCACCGTCTCGCGGACCCTCGCCGGGTGCGGGGCTTT
CATCGTGGACAGCGATGTGATCGCACGCGAGGTGGTGGAACCCGGAACGCCTGGGCTGGCGGCGCTCGTGGAGGCCTTTG
GAGAAACGATACTGCGTGCCGACGGTGCCCTGGATCGTCCGGCATTGGCGGCCATCGCATTCCAGGACGATGAGCACCGC
GCCACTCTCAATGGGATAGTGCATCCGTTGGTGGGGGCGCGCCGGGCTGAACTGATTGCGGCTGCGGGTGAGGAAGCTGT
TGTGGTGGAAGATATTCCGCTGCTCACCGAAAACTCACTCGCGCCGTTTTATCACCTGGTTCTGGTCGTTCACGCGGACA
TCGAAACTCGGGTGACACGGCTTGTCACTCATCGTGGGATGAATGAGCAGGACGCCCGCTCGCGCGTCGCCGCGCAGGCC
TCCGATGAGCAGCGCCGCGCGATCGCGGATGTGTGGCTGGACAACTCTGGCGATACCGAGGTGCTTGCGCACGCGGTGCG
TGATCTGTGGGCTTCCCGGCTGCTGCCCTACGCACATAATCTGCGCATGCGGCAACGCGCGCCGTGGCGGCCCGAGCTGA
TGCCTGCGGATCCGACGTGGCCGGTGCAGGCGCAGCGCGTCATCAATCGCCTTGCGGTGGCTTGTGGCTCGCGGGCGCTG
CGGATCGACCATATCGGCTCCACGGCAGTACCTGGTCTGGATGCCAAAGACGTCATCGATATCCAGGTGACGGTGGAGTC
ACTTGCCGTGGCCGACACGCTGGCGGATCCCTTAGCGGGCATCGGGTTGCCGTCGATCCCGGGTATCACCACAGATGACC
CACATGACTCTGACACCGCCCATTGGGGTAAGCGCATCCATGCCGCAGCCGATCCGGGACGCGCCGTTCTGGTGCACGTG
AGAGTGGACGGCTGGCCGGGGCAGCGATTCGCGCTGATTTTCCGGGATTGGCTGCGGTCCGACCACCAGGCGTGCGCCGA
GTATCTTTCGATCAAGCAGGCGGCTGAGCGGGCGGCGGCTGCGGCCGGCGGCGATCCCGGCGCCTACGTGGATGCCAAGG
AGCCTTGGTTCGCCCAGGCGTACACGCGGGCACTGGATTGGGCCAATGCATCCCAATGGACGCCTTAG

Upstream 100 bases:

>100_bases
CCGGAATCACATTGCCGCGAAGCGCTTTCCATCATCCACCGCAGGTGGATTCGTCGGTGCTGGTGATCAGGCGGCGCTGA
CCCTGTGACAGACTGCGGGC

Downstream 100 bases:

>100_bases
CTTTTCCGTTTCAGTGCTTCTGCTCGACGATGCCGATGCAGGTGGCCGTTAACAGCCTGGTCAGAGCGGGTTCGAAATCG
AGGCTCCAGTCCGGTGGGAC

Product: dephospho-CoA kinase/protein folding accessory domain-containing protein

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLRIGLTGGIGAGKSTVSRTLAGCGAFIVDSDVIAREVVEPGTPGLAALVEAFGETILRADGALDRPALAAIAFQDDEHR
ATLNGIVHPLVGARRAELIAAAGEEAVVVEDIPLLTENSLAPFYHLVLVVHADIETRVTRLVTHRGMNEQDARSRVAAQA
SDEQRRAIADVWLDNSGDTEVLAHAVRDLWASRLLPYAHNLRMRQRAPWRPELMPADPTWPVQAQRVINRLAVACGSRAL
RIDHIGSTAVPGLDAKDVIDIQVTVESLAVADTLADPLAGIGLPSIPGITTDDPHDSDTAHWGKRIHAAADPGRAVLVHV
RVDGWPGQRFALIFRDWLRSDHQACAEYLSIKQAAERAAAAAGGDPGAYVDAKEPWFAQAYTRALDWANASQWTP

Sequences:

>Translated_395_residues
MLRIGLTGGIGAGKSTVSRTLAGCGAFIVDSDVIAREVVEPGTPGLAALVEAFGETILRADGALDRPALAAIAFQDDEHR
ATLNGIVHPLVGARRAELIAAAGEEAVVVEDIPLLTENSLAPFYHLVLVVHADIETRVTRLVTHRGMNEQDARSRVAAQA
SDEQRRAIADVWLDNSGDTEVLAHAVRDLWASRLLPYAHNLRMRQRAPWRPELMPADPTWPVQAQRVINRLAVACGSRAL
RIDHIGSTAVPGLDAKDVIDIQVTVESLAVADTLADPLAGIGLPSIPGITTDDPHDSDTAHWGKRIHAAADPGRAVLVHV
RVDGWPGQRFALIFRDWLRSDHQACAEYLSIKQAAERAAAAAGGDPGAYVDAKEPWFAQAYTRALDWANASQWTP
>Mature_395_residues
MLRIGLTGGIGAGKSTVSRTLAGCGAFIVDSDVIAREVVEPGTPGLAALVEAFGETILRADGALDRPALAAIAFQDDEHR
ATLNGIVHPLVGARRAELIAAAGEEAVVVEDIPLLTENSLAPFYHLVLVVHADIETRVTRLVTHRGMNEQDARSRVAAQA
SDEQRRAIADVWLDNSGDTEVLAHAVRDLWASRLLPYAHNLRMRQRAPWRPELMPADPTWPVQAQRVINRLAVACGSRAL
RIDHIGSTAVPGLDAKDVIDIQVTVESLAVADTLADPLAGIGLPSIPGITTDDPHDSDTAHWGKRIHAAADPGRAVLVHV
RVDGWPGQRFALIFRDWLRSDHQACAEYLSIKQAAERAAAAAGGDPGAYVDAKEPWFAQAYTRALDWANASQWTP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=184, Percent_Identity=35.3260869565217, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI191252795, Length=184, Percent_Identity=35.3260869565217, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI110227607, Length=201, Percent_Identity=31.8407960199005, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI205277394, Length=201, Percent_Identity=31.8407960199005, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI110227605, Length=201, Percent_Identity=31.8407960199005, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI110227603, Length=201, Percent_Identity=31.8407960199005, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI110227601, Length=201, Percent_Identity=31.8407960199005, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786292, Length=191, Percent_Identity=39.7905759162304, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17554944, Length=191, Percent_Identity=35.0785340314136, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320402, Length=208, Percent_Identity=37.0192307692308, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24644728, Length=185, Percent_Identity=33.5135135135135, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24658602, Length=191, Percent_Identity=31.413612565445, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977
- InterPro:   IPR007344 [H]

Pfam domain/function: PF01121 CoaE; PF04229 UPF0157 [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 42471; Mature: 42471

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIGLTGGIGAGKSTVSRTLAGCGAFIVDSDVIAREVVEPGTPGLAALVEAFGETILRA
CEEEEECCCCCCCHHHHHHHHHHCCHHEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
DGALDRPALAAIAFQDDEHRATLNGIVHPLVGARRAELIAAAGEEAVVVEDIPLLTENSL
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
APFYHLVLVVHADIETRVTRLVTHRGMNEQDARSRVAAQASDEQRRAIADVWLDNSGDTE
CHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCCHH
VLAHAVRDLWASRLLPYAHNLRMRQRAPWRPELMPADPTWPVQAQRVINRLAVACGSRAL
HHHHHHHHHHHHHHCHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
RIDHIGSTAVPGLDAKDVIDIQVTVESLAVADTLADPLAGIGLPSIPGITTDDPHDSDTA
EEECCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
HWGKRIHAAADPGRAVLVHVRVDGWPGQRFALIFRDWLRSDHQACAEYLSIKQAAERAAA
HHHHHEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
AAGGDPGAYVDAKEPWFAQAYTRALDWANASQWTP
HCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLRIGLTGGIGAGKSTVSRTLAGCGAFIVDSDVIAREVVEPGTPGLAALVEAFGETILRA
CEEEEECCCCCCCHHHHHHHHHHCCHHEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
DGALDRPALAAIAFQDDEHRATLNGIVHPLVGARRAELIAAAGEEAVVVEDIPLLTENSL
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
APFYHLVLVVHADIETRVTRLVTHRGMNEQDARSRVAAQASDEQRRAIADVWLDNSGDTE
CHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCCHH
VLAHAVRDLWASRLLPYAHNLRMRQRAPWRPELMPADPTWPVQAQRVINRLAVACGSRAL
HHHHHHHHHHHHHHCHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
RIDHIGSTAVPGLDAKDVIDIQVTVESLAVADTLADPLAGIGLPSIPGITTDDPHDSDTA
EEECCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
HWGKRIHAAADPGRAVLVHVRVDGWPGQRFALIFRDWLRSDHQACAEYLSIKQAAERAAA
HHHHHEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
AAGGDPGAYVDAKEPWFAQAYTRALDWANASQWTP
HCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]