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The map label for this gene is lip2 [H]

Identifier: 169629126

GI number: 169629126

Start: 2040547

End: 2041527

Strand: Direct

Name: lip2 [H]

Synonym: MAB_2039

Alternate gene names: 169629126

Gene position: 2040547-2041527 (Clockwise)

Preceding gene: 169629125

Following gene: 169629130

Centisome position: 40.27

GC content: 62.49

Gene sequence:

>981_bases
GTGACCAGCCCCGTTGACCCGCTCCTGATGTCAGTCCTCGAGGCGAGCCCAGCGGTACAGCTCGATCGGCCCGAGGATTT
GACCCTGGCACGTGAGTCCCGCCGCCACGCTGCCCCTAGCGATGCGCAGTTGCCCACGGTGGGTCGTGTGAAGGACACCT
CGATTCCTGTCACCGATGCACCCCCTATTGCGGTGCGCATCTACTGGCCAGCGGGCTTTGAAAGCGCCGGAGAACTCCCA
CTTGTCCTCTACTATCACGGCGGCGGTTTCGCGTTGGGCAGTATCGATACTCACGACTGGGTGGCACGGTCGATATGTGC
ACATATCGAAGCGGTGGTGGTGTCGGTGGATTACCGACTCGCACCGGAAAACCCCTACCCAGCCGCTGTCGATGACGCAT
TTGCCGCACTCAGCTGGGCGGCAGAACACGCCCCCGAATTGGGGGCGGACCCAGCCAGAATCGCCGTAGCTGGCGATTCT
GCCGGTGGCAACCTCGCCACCGTGGCCGCTCAGCTGGCCGAAATCCGCGGCGGCCCACATCTTAAGTTTCAACTGCTCTG
GTATCCGGGCACCACCAGCGATCTTTCCTTGCCGTCGGTCGTCGAGAATGCCGACGGTCCGGTCCTTTCCCGGGACATCA
TGAGGATCTTTGGCCAGGCATATCTCGGTGAGCTATCGGAAACCGCTGACCCGACAGCATTACCGTTCACCGTTGCGCCG
GTCAACGGGAAGCTCGATGGTCTGCCCCCCGCATATATCGCCACCGCGCAACACGACCCGCTTCGAGACGACGGCAAAAT
CTACGCGACGCGACTGGCAGATGCGGGGGTGCCGGTCCAGCTTCGCAACGCCGACACTCTGGTCCACGGCTACCTTGATT
TCGCCAGGATTGTTCCGGCCGCGAATGAGGAGTTTCGGCTTTCCCTCGACGCTTGTAAAACCGCGTTGCAGGCATCTCCT
CGCCCGAAAGCCGGGCCCTGA

Upstream 100 bases:

>100_bases
CTATTGGCATACATCAGCGGGCTGATGGGGCTTGGTTTCTTTTTGGCGCTGACCGTCCGCGACACAACATCCGAGGACAC
CGAGTAGAAGGTAGGAAATC

Downstream 100 bases:

>100_bases
GATCAGAATTCGAGCAAGTTCCACGTTGAGGCCGCAGCTGAGCAGGGTGGCTTGGCGGGTGCTGGGGAGGCCAGCCGGGG
CAGGACATGCCGAGGTCCGT

Product: lipase LipH (carboxylesterase)

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTSPVDPLLMSVLEASPAVQLDRPEDLTLARESRRHAAPSDAQLPTVGRVKDTSIPVTDAPPIAVRIYWPAGFESAGELP
LVLYYHGGGFALGSIDTHDWVARSICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSWAAEHAPELGADPARIAVAGDS
AGGNLATVAAQLAEIRGGPHLKFQLLWYPGTTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVAP
VNGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVHGYLDFARIVPAANEEFRLSLDACKTALQASP
RPKAGP

Sequences:

>Translated_326_residues
MTSPVDPLLMSVLEASPAVQLDRPEDLTLARESRRHAAPSDAQLPTVGRVKDTSIPVTDAPPIAVRIYWPAGFESAGELP
LVLYYHGGGFALGSIDTHDWVARSICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSWAAEHAPELGADPARIAVAGDS
AGGNLATVAAQLAEIRGGPHLKFQLLWYPGTTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVAP
VNGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVHGYLDFARIVPAANEEFRLSLDACKTALQASP
RPKAGP
>Mature_325_residues
TSPVDPLLMSVLEASPAVQLDRPEDLTLARESRRHAAPSDAQLPTVGRVKDTSIPVTDAPPIAVRIYWPAGFESAGELPL
VLYYHGGGFALGSIDTHDWVARSICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSWAAEHAPELGADPARIAVAGDSA
GGNLATVAAQLAEIRGGPHLKFQLLWYPGTTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVAPV
NGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVHGYLDFARIVPAANEEFRLSLDACKTALQASPR
PKAGP

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=308, Percent_Identity=35.3896103896104, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI68299767, Length=306, Percent_Identity=32.0261437908497, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21328446, Length=102, Percent_Identity=39.2156862745098, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI157041239, Length=133, Percent_Identity=35.3383458646617, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI68051721, Length=142, Percent_Identity=36.6197183098592, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI61966717, Length=172, Percent_Identity=32.5581395348837, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI226423947, Length=150, Percent_Identity=34, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786682, Length=230, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI72001146, Length=139, Percent_Identity=39.568345323741, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996133, Length=127, Percent_Identity=37.7952755905512, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17540028, Length=127, Percent_Identity=37.007874015748, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17567059, Length=112, Percent_Identity=39.2857142857143, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533412, Length=143, Percent_Identity=32.8671328671329, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533410, Length=143, Percent_Identity=32.8671328671329, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656084, Length=100, Percent_Identity=37, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656076, Length=100, Percent_Identity=37, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130169, Length=100, Percent_Identity=37, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 34503; Mature: 34372

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS01174 LIPASE_GDXG_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPVDPLLMSVLEASPAVQLDRPEDLTLARESRRHAAPSDAQLPTVGRVKDTSIPVTDA
CCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
PPIAVRIYWPAGFESAGELPLVLYYHGGGFALGSIDTHDWVARSICAHIEAVVVSVDYRL
CCEEEEEEECCCCCCCCCCEEEEEEECCCEEECCCCCHHHHHHHHHHHHEEEEEEEEEEE
APENPYPAAVDDAFAALSWAAEHAPELGADPARIAVAGDSAGGNLATVAAQLAEIRGGPH
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCC
LKFQLLWYPGTTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVAP
EEEEEEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
VNGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVHGYLDFARIVPA
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCC
ANEEFRLSLDACKTALQASPRPKAGP
CCCCEEEEHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TSPVDPLLMSVLEASPAVQLDRPEDLTLARESRRHAAPSDAQLPTVGRVKDTSIPVTDA
CCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
PPIAVRIYWPAGFESAGELPLVLYYHGGGFALGSIDTHDWVARSICAHIEAVVVSVDYRL
CCEEEEEEECCCCCCCCCCEEEEEEECCCEEECCCCCHHHHHHHHHHHHEEEEEEEEEEE
APENPYPAAVDDAFAALSWAAEHAPELGADPARIAVAGDSAGGNLATVAAQLAEIRGGPH
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCC
LKFQLLWYPGTTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVAP
EEEEEEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
VNGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVHGYLDFARIVPA
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCC
ANEEFRLSLDACKTALQASPRPKAGP
CCCCEEEEHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]