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The map label for this gene is gcvT [H]

Identifier: 169629036

GI number: 169629036

Start: 1947348

End: 1948442

Strand: Direct

Name: gcvT [H]

Synonym: MAB_1949

Alternate gene names: 169629036

Gene position: 1947348-1948442 (Clockwise)

Preceding gene: 169629034

Following gene: 169629037

Centisome position: 38.43

GC content: 67.03

Gene sequence:

>1095_bases
ATGACGGACCTCTTGCTCGGACCACTGCACGATCGGCACGCCGCTCAGGGCGCAACCTTTGCCGAGTTCGGCGGCTGGAA
TATGCCGGTGTCGTACGCGGGAACGGTGGGAGAGCACACCGCCACCCGCGCGGCGGTCGGACTGTTCGACGTGAGTCACC
TCGGCAAGGCGCTGGTACGTGGACCGGGAGCGGCAGCCTTCGTCAACGCGTGTTTTACCAATGATCTCAACAAGGTTGGG
CCCGGCAAGGCGCAGTACACCTTGTGCTGCACCGAGACCGGCGGGGTGATTGACGACCTCATCGCGTACTACGTATCCGA
CGACGAGATCTTCCTGGTGCCCAACGCCGCCAATACCTCCGCCGTGGTCGCGGCATTGCAGGAGCAGGCGCCGGAGGGGA
TCGCCGTCACCAATCAGCATCGCGACTACGCGGTGCTTGCGGTGCAGGGGCCCAGGTCCGCGGACGTGCTGCAACGGCTG
GGTCTGCCAACGGATATGGAGTACATGGCCTACGCCGACGCCACGCTCGCCGGTCTGCCCGTGCGGGTGTGCCGTACCGG
TTACACCGGCGAGCACGGTTACGAGCTGTTGCCGTCCTGGGACGACGCCGGTGCCGTGTTCGATGCCCTGCTGCCCGTGA
TCACCGAGGCGGGTGGGCAGCTCGCCGGTCTGGGAGCGCGTGACACGCTGCGCACCGAGATGGGCTATCCGCTACACGGG
CATGAGCTTTCCCTGGACATCAGCCCCGTGCAGGCACGGGCCGGATGGGCGGTGGGCTGGAAGAAGGACGCGTTCTGGGG
TCGCGAGGCGCTGACGCAGGAGAAGACGGATGGTCCACGCCGCACGCTACGAGGCCTGCGCGCGACCGGCCGGGGGGTGC
TGCGCCCCGATCTCACGGTGCTCTCCGATGGCCAGTCGATCGGTGTCACCACCTCCGGGACCTTCTCACCGACCCTGAAG
ACCGGAATCGCCCTGGCCCTGCTGGACACCGCGGCCCAGATCCCGGACGGCGCGAGCGTCGTCGTCGATGTGCGTGGCCG
TGAGATCGAATGCGAGGTCGTCAAGCCGCCATTCGTGGACGTCAACGTCGGATAA

Upstream 100 bases:

>100_bases
GCCGTGTATGCGCTCATAGGTTCACAGCCTAGTGAAGGCCGATGAGGCGCCAACCGGGATGAGGCCCTGGTGCGAAGACC
ATGTGGCTAGGGTGAACGCC

Downstream 100 bases:

>100_bases
TGGGTTCGGATTCGGCGACGGCAGACGGTTAGACTGCCGAGCATGAATCCGCTTCCCGCGTTCACCCGGCAACTCAACCC
GTCACCGGCCAGCCCGGCGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGTVGEHTATRAAVGLFDVSHLGKALVRGPGAAAFVNACFTNDLNKVG
PGKAQYTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTSAVVAALQEQAPEGIAVTNQHRDYAVLAVQGPRSADVLQRL
GLPTDMEYMAYADATLAGLPVRVCRTGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARDTLRTEMGYPLHG
HELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDGPRRTLRGLRATGRGVLRPDLTVLSDGQSIGVTTSGTFSPTLK
TGIALALLDTAAQIPDGASVVVDVRGREIECEVVKPPFVDVNVG

Sequences:

>Translated_364_residues
MTDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGTVGEHTATRAAVGLFDVSHLGKALVRGPGAAAFVNACFTNDLNKVG
PGKAQYTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTSAVVAALQEQAPEGIAVTNQHRDYAVLAVQGPRSADVLQRL
GLPTDMEYMAYADATLAGLPVRVCRTGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARDTLRTEMGYPLHG
HELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDGPRRTLRGLRATGRGVLRPDLTVLSDGQSIGVTTSGTFSPTLK
TGIALALLDTAAQIPDGASVVVDVRGREIECEVVKPPFVDVNVG
>Mature_363_residues
TDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGTVGEHTATRAAVGLFDVSHLGKALVRGPGAAAFVNACFTNDLNKVGP
GKAQYTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTSAVVAALQEQAPEGIAVTNQHRDYAVLAVQGPRSADVLQRLG
LPTDMEYMAYADATLAGLPVRVCRTGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARDTLRTEMGYPLHGH
ELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDGPRRTLRGLRATGRGVLRPDLTVLSDGQSIGVTTSGTFSPTLKT
GIALALLDTAAQIPDGASVVVDVRGREIECEVVKPPFVDVNVG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=371, Percent_Identity=32.8840970350404, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI257796258, Length=334, Percent_Identity=33.2335329341317, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI257796254, Length=364, Percent_Identity=30.2197802197802, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI257796256, Length=319, Percent_Identity=31.6614420062696, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI24797151, Length=345, Percent_Identity=27.536231884058, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI197927446, Length=402, Percent_Identity=25.3731343283582, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI21361378, Length=402, Percent_Identity=25.3731343283582, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1789272, Length=365, Percent_Identity=39.1780821917808, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=34.0482573726542, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994052, Length=397, Percent_Identity=24.9370277078086, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=397, Percent_Identity=24.9370277078086, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32563613, Length=395, Percent_Identity=21.7721518987342, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=379, Percent_Identity=30.0791556728232, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=33.1550802139037, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI20130091, Length=340, Percent_Identity=24.7058823529412, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38371; Mature: 38240

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGTVGEHTATRAAVGLFDVSHLGKALVR
CCCCEECCCCHHHHHCCCCCHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPGAAAFVNACFTNDLNKVGPGKAQYTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTS
CCCHHHHHHHHHHCCHHHCCCCCCEEEEEECCCCCHHHHHHHHEECCCEEEEEECCCCHH
AVVAALQEQAPEGIAVTNQHRDYAVLAVQGPRSADVLQRLGLPTDMEYMAYADATLAGLP
HHHHHHHHHCCCCCEEECCCCCEEEEEEECCCHHHHHHHCCCCCCCHHHHCCCCHHCCCC
VRVCRTGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARDTLRTEMGYPLHG
CEEHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHCCCCCCC
HELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDGPRRTLRGLRATGRGVLRPDLTV
CEEEEECCCCHHCCCEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEE
LSDGQSIGVTTSGTFSPTLKTGIALALLDTAAQIPDGASVVVDVRGREIECEVVKPPFVD
EECCCEEEEEECCCCCCHHHHCCHHEEHHHHHHCCCCCEEEEEECCCEEEEEEECCCEEE
VNVG
EECC
>Mature Secondary Structure 
TDLLLGPLHDRHAAQGATFAEFGGWNMPVSYAGTVGEHTATRAAVGLFDVSHLGKALVR
CCCEECCCCHHHHHCCCCCHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPGAAAFVNACFTNDLNKVGPGKAQYTLCCTETGGVIDDLIAYYVSDDEIFLVPNAANTS
CCCHHHHHHHHHHCCHHHCCCCCCEEEEEECCCCCHHHHHHHHEECCCEEEEEECCCCHH
AVVAALQEQAPEGIAVTNQHRDYAVLAVQGPRSADVLQRLGLPTDMEYMAYADATLAGLP
HHHHHHHHHCCCCCEEECCCCCEEEEEEECCCHHHHHHHCCCCCCCHHHHCCCCHHCCCC
VRVCRTGYTGEHGYELLPSWDDAGAVFDALLPVITEAGGQLAGLGARDTLRTEMGYPLHG
CEEHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHCCCCCCC
HELSLDISPVQARAGWAVGWKKDAFWGREALTQEKTDGPRRTLRGLRATGRGVLRPDLTV
CEEEEECCCCHHCCCEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEE
LSDGQSIGVTTSGTFSPTLKTGIALALLDTAAQIPDGASVVVDVRGREIECEVVKPPFVD
EECCCEEEEEECCCCCCHHHHCCHHEEHHHHHHCCCCCEEEEEECCCEEEEEEECCCEEE
VNVG
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]