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The map label for this gene is sir [H]

Identifier: 169628752

GI number: 169628752

Start: 1689645

End: 1691327

Strand: Reverse

Name: sir [H]

Synonym: MAB_1662c

Alternate gene names: 169628752

Gene position: 1691327-1689645 (Counterclockwise)

Preceding gene: 169628754

Following gene: 169628751

Centisome position: 33.38

GC content: 65.54

Gene sequence:

>1683_bases
ATGACAACCAGCGAGACCCGGCCCGCTCGCCCCAAGCAGCAACGCAGTGAGGGCCAGTGGGCCCTGGGCGAGCTCGAGCC
GCTCAACTCCAACGAGCAGGTCAAGAAGGACGACCATCCGCTCAATGTGCGCGAGCGCATCGAAACCATTTACTCCAAGC
AGGGTTTCGACAGCATCGACAAGGCCGATCTGCGTGGCCGCTTCCGGTGGTGGGGTCTGTACACACAGCGCAAGCAGGGT
TACGACGGCACCTGGACGGGTGACGACAACACCGACATGCTCGAGGACGACCACTTCATGCTGCGGGTGCGTTGCGACGG
CGGCGCGCTGACCACGCAGGCGCTGCGCACCATCGGCGAGCTGTCCACTCAGTACGCCCGCGACACCGCGGACATCTCGG
ACCGCCAGAACGTGCAGTACCACTGGATCCGGGTGGAGGACATGCCCGAGATCTGGCGGCGGCTGGACGAGGTCGGCCTC
TACACGACCCAGGCCTGCGGTGACTGCCCCCGCGTGATCCTCGGGTCGCCGCTGGCAGGCGAGTCCCTGGACGAGGTGCT
CGACCCGACGTGGGCAATCGACGAGATCACCCGCCGCTACATCGGCAACAAGGAGTACGCGAACCTCCCCCGCAAGTTCA
AGACGGCGATCTCCGGCCTGCAGGACGTGGTGCACGAGATCAACGACGTCGCGTTCGTCGGTGTGGTGCATCCCGAGCAC
GGCCCCGGTCTGGACATATGGGTGGGCGGTGGCCTGTCGACCAACCCGATGCTGGCCCAGCGCCTCGGTGCGTGGGTGCC
CCTGGACGAGGTGCCCGACGTATGGGAGGGCGTCGTCGGAATCTTCCGCGACTACGGCTACCGCCGCCTGCGTTCCAAGG
CCCGGCTGAAGTTCCTGGTCAAGGACTGGGGCGTGGCGAAGTTCAGGGAAATTCTCGAGACCGAGTACCTAAAGCGGCCG
CTGATCGACGGGCCCGCGCCCGTTCCCCCCACGCACCCGATCGATCACGTCGGTGTGCAGCGACTCAAGAACGGGCTCAA
CGCCATCGGCATTTCGGCCATCGCCGGGCGGGTCTCCGGCACCATTCTGTCGGCGATCGCCGACCTGGCCGAGAAGGCGG
GCTCCAACCGGGTGGCCCTGACCCCGCACCAGAAGCTGATCATTCTGGACGTCAGTGATGACGAGCTGCCTGCGCTCGAG
GCCGGACTCAACGCGCTGGGGCTGCCGTCCCGGCCCTCGCATTGGCGCAAGAACCTGTTGGCCTGCACCGGCATTGAGTA
CTGCAAGTTGTCCTTCACCGAAACCCGGGTGCGGGCCCAGAGTTTGGTTCCCGAGCTGGAGAAGCGGCTCGATGATCTGA
ACGCCCAGATCGATACGCCCGTCACCATCAACATGAATGGCTGCCCCAACTCGTGCGCACGGTCCCAGACCGCCGACATC
GGATTCAAGGGCCAGATGGTCGACGACGGAAACGGGAACAGCGTGGAAGGCTTCCAGGTGCATCTGGGCGGAAGCCTGGG
TCTGGACAGCGGATTCGGCCGCAAGTTGCGTCAGCACAAGGTCACCAGCACCGAGCTCGGCGATTACATCGACCGGGTGG
TGCGCAATTTCGTCGCGCAGCGCACCGACGGAGAGCGCTTCGCGCAGTGGGCGGTTCGCGCTGAGGAGGCGGACTTGCGA
TGA

Upstream 100 bases:

>100_bases
CCGTCCTACCACCAGCCACCCGAACGGTCGTGAGGATCTGCGCCTCCGGTCAGCCCCCGGTGTGTCGCCCACGACTGTGC
CTGCCTTCGTTAGGAGCACC

Downstream 100 bases:

>100_bases
GCCGGGAGACAACCACCAAGGATCTCGATTCGCTGCGCGCGCTGGCCGAACGCGGCGCCGCCGAATTGCAGGACGCTTCC
GCCGAGGAGCTGCTGCGGTG

Product: sulfite reductase [ferredoxin]

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTTSETRPARPKQQRSEGQWALGELEPLNSNEQVKKDDHPLNVRERIETIYSKQGFDSIDKADLRGRFRWWGLYTQRKQG
YDGTWTGDDNTDMLEDDHFMLRVRCDGGALTTQALRTIGELSTQYARDTADISDRQNVQYHWIRVEDMPEIWRRLDEVGL
YTTQACGDCPRVILGSPLAGESLDEVLDPTWAIDEITRRYIGNKEYANLPRKFKTAISGLQDVVHEINDVAFVGVVHPEH
GPGLDIWVGGGLSTNPMLAQRLGAWVPLDEVPDVWEGVVGIFRDYGYRRLRSKARLKFLVKDWGVAKFREILETEYLKRP
LIDGPAPVPPTHPIDHVGVQRLKNGLNAIGISAIAGRVSGTILSAIADLAEKAGSNRVALTPHQKLIILDVSDDELPALE
AGLNALGLPSRPSHWRKNLLACTGIEYCKLSFTETRVRAQSLVPELEKRLDDLNAQIDTPVTINMNGCPNSCARSQTADI
GFKGQMVDDGNGNSVEGFQVHLGGSLGLDSGFGRKLRQHKVTSTELGDYIDRVVRNFVAQRTDGERFAQWAVRAEEADLR

Sequences:

>Translated_560_residues
MTTSETRPARPKQQRSEGQWALGELEPLNSNEQVKKDDHPLNVRERIETIYSKQGFDSIDKADLRGRFRWWGLYTQRKQG
YDGTWTGDDNTDMLEDDHFMLRVRCDGGALTTQALRTIGELSTQYARDTADISDRQNVQYHWIRVEDMPEIWRRLDEVGL
YTTQACGDCPRVILGSPLAGESLDEVLDPTWAIDEITRRYIGNKEYANLPRKFKTAISGLQDVVHEINDVAFVGVVHPEH
GPGLDIWVGGGLSTNPMLAQRLGAWVPLDEVPDVWEGVVGIFRDYGYRRLRSKARLKFLVKDWGVAKFREILETEYLKRP
LIDGPAPVPPTHPIDHVGVQRLKNGLNAIGISAIAGRVSGTILSAIADLAEKAGSNRVALTPHQKLIILDVSDDELPALE
AGLNALGLPSRPSHWRKNLLACTGIEYCKLSFTETRVRAQSLVPELEKRLDDLNAQIDTPVTINMNGCPNSCARSQTADI
GFKGQMVDDGNGNSVEGFQVHLGGSLGLDSGFGRKLRQHKVTSTELGDYIDRVVRNFVAQRTDGERFAQWAVRAEEADLR
>Mature_559_residues
TTSETRPARPKQQRSEGQWALGELEPLNSNEQVKKDDHPLNVRERIETIYSKQGFDSIDKADLRGRFRWWGLYTQRKQGY
DGTWTGDDNTDMLEDDHFMLRVRCDGGALTTQALRTIGELSTQYARDTADISDRQNVQYHWIRVEDMPEIWRRLDEVGLY
TTQACGDCPRVILGSPLAGESLDEVLDPTWAIDEITRRYIGNKEYANLPRKFKTAISGLQDVVHEINDVAFVGVVHPEHG
PGLDIWVGGGLSTNPMLAQRLGAWVPLDEVPDVWEGVVGIFRDYGYRRLRSKARLKFLVKDWGVAKFREILETEYLKRPL
IDGPAPVPPTHPIDHVGVQRLKNGLNAIGISAIAGRVSGTILSAIADLAEKAGSNRVALTPHQKLIILDVSDDELPALEA
GLNALGLPSRPSHWRKNLLACTGIEYCKLSFTETRVRAQSLVPELEKRLDDLNAQIDTPVTINMNGCPNSCARSQTADIG
FKGQMVDDGNGNSVEGFQVHLGGSLGLDSGFGRKLRQHKVTSTELGDYIDRVVRNFVAQRTDGERFAQWAVRAEEADLR

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Escherichia coli, GI1789122, Length=526, Percent_Identity=24.9049429657795, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322597, Length=369, Percent_Identity=28.7262872628726, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 62584; Mature: 62453

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSETRPARPKQQRSEGQWALGELEPLNSNEQVKKDDHPLNVRERIETIYSKQGFDSID
CCCCCCCCCCCHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
KADLRGRFRWWGLYTQRKQGYDGTWTGDDNTDMLEDDHFMLRVRCDGGALTTQALRTIGE
HHHHCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHH
LSTQYARDTADISDRQNVQYHWIRVEDMPEIWRRLDEVGLYTTQACGDCPRVILGSPLAG
HHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCEEHHHCCCCCHHHHCCCCCC
ESLDEVLDPTWAIDEITRRYIGNKEYANLPRKFKTAISGLQDVVHEINDVAFVGVVHPEH
CCHHHHHCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
GPGLDIWVGGGLSTNPMLAQRLGAWVPLDEVPDVWEGVVGIFRDYGYRRLRSKARLKFLV
CCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDWGVAKFREILETEYLKRPLIDGPAPVPPTHPIDHVGVQRLKNGLNAIGISAIAGRVSG
HHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
TILSAIADLAEKAGSNRVALTPHQKLIILDVSDDELPALEAGLNALGLPSRPSHWRKNLL
HHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHH
ACTGIEYCKLSFTETRVRAQSLVPELEKRLDDLNAQIDTPVTINMNGCPNSCARSQTADI
HHCCCHHHEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHCCCCCCC
GFKGQMVDDGNGNSVEGFQVHLGGSLGLDSGFGRKLRQHKVTSTELGDYIDRVVRNFVAQ
CCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RTDGERFAQWAVRAEEADLR
CCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTSETRPARPKQQRSEGQWALGELEPLNSNEQVKKDDHPLNVRERIETIYSKQGFDSID
CCCCCCCCCCHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
KADLRGRFRWWGLYTQRKQGYDGTWTGDDNTDMLEDDHFMLRVRCDGGALTTQALRTIGE
HHHHCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHH
LSTQYARDTADISDRQNVQYHWIRVEDMPEIWRRLDEVGLYTTQACGDCPRVILGSPLAG
HHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCEEHHHCCCCCHHHHCCCCCC
ESLDEVLDPTWAIDEITRRYIGNKEYANLPRKFKTAISGLQDVVHEINDVAFVGVVHPEH
CCHHHHHCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
GPGLDIWVGGGLSTNPMLAQRLGAWVPLDEVPDVWEGVVGIFRDYGYRRLRSKARLKFLV
CCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDWGVAKFREILETEYLKRPLIDGPAPVPPTHPIDHVGVQRLKNGLNAIGISAIAGRVSG
HHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
TILSAIADLAEKAGSNRVALTPHQKLIILDVSDDELPALEAGLNALGLPSRPSHWRKNLL
HHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHH
ACTGIEYCKLSFTETRVRAQSLVPELEKRLDDLNAQIDTPVTINMNGCPNSCARSQTADI
HHCCCHHHEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHCCCCCCC
GFKGQMVDDGNGNSVEGFQVHLGGSLGLDSGFGRKLRQHKVTSTELGDYIDRVVRNFVAQ
CCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RTDGERFAQWAVRAEEADLR
CCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]