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The map label for this gene is thrB

Identifier: 169628528

GI number: 169628528

Start: 1442246

End: 1443166

Strand: Direct

Name: thrB

Synonym: MAB_1437

Alternate gene names: 169628528

Gene position: 1442246-1443166 (Clockwise)

Preceding gene: 169628527

Following gene: 169628529

Centisome position: 28.46

GC content: 64.93

Gene sequence:

>921_bases
GTGAGCGAGGTGCTGCCCGCGGGGCTGGCCACCACGGTCCTGGTGCCCGCATCGAGTGCGAACCTGGGCCCGGGCTTCGA
CAGCCTCGGGATCGCACTGTCGCTGTACGACGAGATCGAGGTCAATACAACCGAATCCGGTCTCAAGGTGGCCGTCGAGG
GTCAGGGCGCCGGAGAGGTTCCGCTCGACGGTAGCCACCTCGTTGTGCGTGCGATCGAGCGCGGGCTCGCTGCCGGTGGA
GCTGCCGCCCCAGGCCTGATTGTCCAGTGCCACAACAAAATTCCGCACTCGCGAGGTCTGGGATCGTCGGCCGCGGCAGC
AGTAGCCGGTCTGGGTGTGGCCAATGGGTTGCTTGCCAAGGCCGGGCGCGCGGTGCTTTCCGACGACGTGCTGGTGCAGC
TGGCGTCGGAGTTCGAGGGACATCCGGACAACGCCGCGGCCAGCGTGCTAGGCGGTGCCGTGGTGTCATGGTCGGAGACG
TCGGGGGCGACCCCGATTTATGCCGCTACCCGCCTCGATGTGCATCCCGATATCAAAATTGTCGCGGCCATTCCCGAGGA
GCAGTCCTCCACTGCGCACACTCGGGTATTGCTGCCCCAAGCTGTCACACATGTAGATGCTCGTTTTAATATTAGCCGTG
TCGCTCTGCTGACCGTCGCTCTCACCGCGCGGCCGGACCTGCTCATGACGGCTACCGAGGATCGGTTGCACCAACCGCAG
CGAGCGTCGGCGATGCCGGCGTCCGCGGATGTCCTGGCGTACCTGCGGAGCCAGGGTGTCGCGGCCGTCCTTTCGGGTGC
TGGACCTGCGGTGTTGGCGTTGACAACCGTCGATCTGCCCGATTCGGCGGTGAAATACGCTGAAGATCAAGGTTTCTCAC
TGGTAGCCATGGCTGTGTCGGCGGGTGTGTCGGTTCGATAG

Upstream 100 bases:

>100_bases
GCAACGGCCTGAAGGATCCCGACAATGCGCTGAGCGGAATGCCCGAGGTGACTCCCATCCCGGTCCAGGCGAGTGCCGTC
GCCGAGGCGCTGGAACTGGC

Downstream 100 bases:

>100_bases
CCGACGTTATGGCTGGTGAGCCCGGGGGACTCGCCGGGGGTGCTGGTTGCTTGATGCTCGGCCGGGGGTTATCCTCGATA
TCAGTCCCAGCAATTGCAGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSEVLPAGLATTVLVPASSANLGPGFDSLGIALSLYDEIEVNTTESGLKVAVEGQGAGEVPLDGSHLVVRAIERGLAAGG
AAAPGLIVQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAKAGRAVLSDDVLVQLASEFEGHPDNAAASVLGGAVVSWSET
SGATPIYAATRLDVHPDIKIVAAIPEEQSSTAHTRVLLPQAVTHVDARFNISRVALLTVALTARPDLLMTATEDRLHQPQ
RASAMPASADVLAYLRSQGVAAVLSGAGPAVLALTTVDLPDSAVKYAEDQGFSLVAMAVSAGVSVR

Sequences:

>Translated_306_residues
MSEVLPAGLATTVLVPASSANLGPGFDSLGIALSLYDEIEVNTTESGLKVAVEGQGAGEVPLDGSHLVVRAIERGLAAGG
AAAPGLIVQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAKAGRAVLSDDVLVQLASEFEGHPDNAAASVLGGAVVSWSET
SGATPIYAATRLDVHPDIKIVAAIPEEQSSTAHTRVLLPQAVTHVDARFNISRVALLTVALTARPDLLMTATEDRLHQPQ
RASAMPASADVLAYLRSQGVAAVLSGAGPAVLALTTVDLPDSAVKYAEDQGFSLVAMAVSAGVSVR
>Mature_305_residues
SEVLPAGLATTVLVPASSANLGPGFDSLGIALSLYDEIEVNTTESGLKVAVEGQGAGEVPLDGSHLVVRAIERGLAAGGA
AAPGLIVQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAKAGRAVLSDDVLVQLASEFEGHPDNAAASVLGGAVVSWSETS
GATPIYAATRLDVHPDIKIVAAIPEEQSSTAHTRVLLPQAVTHVDARFNISRVALLTVALTARPDLLMTATEDRLHQPQR
ASAMPASADVLAYLRSQGVAAVLSGAGPAVLALTTVDLPDSAVKYAEDQGFSLVAMAVSAGVSVR

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=318, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321814, Length=323, Percent_Identity=33.1269349845201, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_MYCA9 (B1MLU6)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702177.1
- ProteinModelPortal:   B1MLU6
- SMR:   B1MLU6
- EnsemblBacteria:   EBMYCT00000006107
- GeneID:   5963959
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_1437
- GeneTree:   EBGT00050000016145
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   MABS561007:MAB_1437-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 30847; Mature: 30716

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLPAGLATTVLVPASSANLGPGFDSLGIALSLYDEIEVNTTESGLKVAVEGQGAGEV
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEECCCCCCC
PLDGSHLVVRAIERGLAAGGAAAPGLIVQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAK
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AGRAVLSDDVLVQLASEFEGHPDNAAASVLGGAVVSWSETSGATPIYAATRLDVHPDIKI
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCEEE
VAAIPEEQSSTAHTRVLLPQAVTHVDARFNISRVALLTVALTARPDLLMTATEDRLHQPQ
EEECCCCCCCCCCEEEECHHHHHHHHCCCCHHHEEEEEEEECCCCCEEEEECHHHHCCCC
RASAMPASADVLAYLRSQGVAAVLSGAGPAVLALTTVDLPDSAVKYAEDQGFSLVAMAVS
HHCCCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCEEEEEEHH
AGVSVR
CCCCCC
>Mature Secondary Structure 
SEVLPAGLATTVLVPASSANLGPGFDSLGIALSLYDEIEVNTTESGLKVAVEGQGAGEV
CCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEECCCCCCC
PLDGSHLVVRAIERGLAAGGAAAPGLIVQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAK
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AGRAVLSDDVLVQLASEFEGHPDNAAASVLGGAVVSWSETSGATPIYAATRLDVHPDIKI
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCEEE
VAAIPEEQSSTAHTRVLLPQAVTHVDARFNISRVALLTVALTARPDLLMTATEDRLHQPQ
EEECCCCCCCCCCEEEECHHHHHHHHCCCCHHHEEEEEEEECCCCCEEEEECHHHHCCCC
RASAMPASADVLAYLRSQGVAAVLSGAGPAVLALTTVDLPDSAVKYAEDQGFSLVAMAVS
HHCCCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCEEEEEEHH
AGVSVR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA