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The map label for this gene is emrY [C]

Identifier: 169628487

GI number: 169628487

Start: 1396309

End: 1397781

Strand: Direct

Name: emrY [C]

Synonym: MAB_1396

Alternate gene names: 169628487

Gene position: 1396309-1397781 (Clockwise)

Preceding gene: 169628486

Following gene: 169628490

Centisome position: 27.56

GC content: 64.9

Gene sequence:

>1473_bases
GTGCGACCTGAATATCCGCGACCGTGGATCACCTTGTGGGTGGTGCTGTTCGGGTTGTTCATGATCTTGCTCGACTCGAC
GATTGTGTCGGTCGCCAATCCGGCCATCAAGGCAGGTTTCGGTGCCGATTATTCGTCGACGGTATGGGTGACCAGTGCAT
ATCTGCTGGGCTACGCGGTGCCGCTGCTGATTACCGGGCGACTCGGAGATCAATTCGGCCCACGCTCGATGTACCTGTCC
GGGCTCGCGGTCTTCACCGCAGCCTCGCTGTGGTGCGGCTTGGCGGGGTCGATCGGCTGGCTTATCGCGGCGCGCGTGGT
GCAGGGGATCGGTGCGGCGATGCTCACGCCGCAGACGTTGACCGTGGTGCAGCGGGTGTTCCCGCCGGAGCGGCGTGGGA
CCGCGATGGGGGTGTGGGGTGCGGTAGCCGGGATCGCGACGCTGGTGGGCCCGGTGGCCGGTGGTCTGCTCGTGGACGGG
TGGGGCTGGCAGTGGATCTTCTATGTCAATGTTCCGGTGGGTGTGCTGGGAATCATCCTGGGCGCCATCTATATTCCGCG
AATGCCGACACATCGGCATCGGCTAGACCTGCTGGGGATGGCACTTTCGGCCGTCGGCATGTTTGCCTTCGTTTTCGCGC
TCCAAGAGGGAGAGAGCTTCCAGTGGGCTCCTGGCGTGTGGGCGATGATGGCCGCTGGCCTAGTGGTTTTGGGTGTGTTC
GTGTGGTGGCAGTCGGCGAACCGGGGGGAGCCGCTGATCCCATTGCGATTGTTCGCCGACCGCAACTTTTCGCTTGCCGG
CGTCGGTATCGCGTCGATGAGTTTCTGTGTGATCTCGACCGGTCTGCCCATGATGTTCTATACGCAACTGGCACTCGGCT
TTTCGCCGACAAAGGCGGCGTTGACCCAGGCGCCCACGGCGATTGTGAGTGGAATTCTGGCGCCCCTAGCCGGATGGCTG
GTCGACAGGGTGCGTCCATCGATACTGATCGGCGGCGGTATCGCGTTGATGATCGCCTCGACGCTGTGGTGGACGCTGTT
GATGCGGCCTGAGACCCAGATGTGGCAACTCATGCTTCCGGCGGCGGGTATCGGCGCGGCCATGGCGTGCATCTGGGGTC
CACTGGCCACTACCGCGACGCGAAACCTGCCGCCGTCGGTCGCGGGCGCCGGGTCTGGCGTCTACAACACACTGCGGCAG
GTCGGCGGCGTGGTCGGCAGTTCGGCGATGGGTGCGTTGATGACGGCGCGATTGACGGCGACCATGCCCGCCATGCCTCC
CGGTTCCGGGTCCACCCCGGAGGCAGCGCTGCCTCCGGGCTTGCGTGCGCCGTTCTCGGCCGCGATGGCACAGTCCATGC
TGCTGGGTATCGCGGCGCTGGCACTTGGTCTGGTGGCCGCGCTGTTCATGCGGCCCGGAGGCTCACAGGTAGGTGCCGTG
CCCCTCGACGATGTGGTCTCCGTCGAAGATTAG

Upstream 100 bases:

>100_bases
GTCGCCATCGTCATGATGATCGGAGTGGTGCTGGCTCTGGCCGGGCTGGCCGTCGTGAGAAATCGTGTCGCTGCCTGACC
GACGACTAAGTTCCGTAGCC

Downstream 100 bases:

>100_bases
GACCTCATTGACGAGTCCGCCCTTGTGGTTTCGGTAGTTGAGGACGAGGGCCCGGGCGCCCACGTAGGTGCCGACCGGTT
CGAAGCGCAGATCAGGGTTG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MRPEYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSAYLLGYAVPLLITGRLGDQFGPRSMYLS
GLAVFTAASLWCGLAGSIGWLIAARVVQGIGAAMLTPQTLTVVQRVFPPERRGTAMGVWGAVAGIATLVGPVAGGLLVDG
WGWQWIFYVNVPVGVLGIILGAIYIPRMPTHRHRLDLLGMALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVF
VWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTKAALTQAPTAIVSGILAPLAGWL
VDRVRPSILIGGGIALMIASTLWWTLLMRPETQMWQLMLPAAGIGAAMACIWGPLATTATRNLPPSVAGAGSGVYNTLRQ
VGGVVGSSAMGALMTARLTATMPAMPPGSGSTPEAALPPGLRAPFSAAMAQSMLLGIAALALGLVAALFMRPGGSQVGAV
PLDDVVSVED

Sequences:

>Translated_490_residues
MRPEYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSAYLLGYAVPLLITGRLGDQFGPRSMYLS
GLAVFTAASLWCGLAGSIGWLIAARVVQGIGAAMLTPQTLTVVQRVFPPERRGTAMGVWGAVAGIATLVGPVAGGLLVDG
WGWQWIFYVNVPVGVLGIILGAIYIPRMPTHRHRLDLLGMALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVF
VWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTKAALTQAPTAIVSGILAPLAGWL
VDRVRPSILIGGGIALMIASTLWWTLLMRPETQMWQLMLPAAGIGAAMACIWGPLATTATRNLPPSVAGAGSGVYNTLRQ
VGGVVGSSAMGALMTARLTATMPAMPPGSGSTPEAALPPGLRAPFSAAMAQSMLLGIAALALGLVAALFMRPGGSQVGAV
PLDDVVSVED
>Mature_490_residues
MRPEYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSAYLLGYAVPLLITGRLGDQFGPRSMYLS
GLAVFTAASLWCGLAGSIGWLIAARVVQGIGAAMLTPQTLTVVQRVFPPERRGTAMGVWGAVAGIATLVGPVAGGLLVDG
WGWQWIFYVNVPVGVLGIILGAIYIPRMPTHRHRLDLLGMALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVF
VWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTKAALTQAPTAIVSGILAPLAGWL
VDRVRPSILIGGGIALMIASTLWWTLLMRPETQMWQLMLPAAGIGAAMACIWGPLATTATRNLPPSVAGAGSGVYNTLRQ
VGGVVGSSAMGALMTARLTATMPAMPPGSGSTPEAALPPGLRAPFSAAMAQSMLLGIAALALGLVAALFMRPGGSQVGAV
PLDDVVSVED

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=440, Percent_Identity=28.6363636363636, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1789042, Length=404, Percent_Identity=28.960396039604, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87081983, Length=422, Percent_Identity=29.3838862559242, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788392, Length=408, Percent_Identity=31.1274509803922, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1790195, Length=413, Percent_Identity=28.8135593220339, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1790146, Length=142, Percent_Identity=26.7605633802817, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788509, Length=137, Percent_Identity=35.036496350365, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=474, Percent_Identity=24.8945147679325, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321663, Length=173, Percent_Identity=30.635838150289, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324954, Length=303, Percent_Identity=27.3927392739274, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323520, Length=309, Percent_Identity=25.8899676375405, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319770, Length=312, Percent_Identity=24.3589743589744, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=444, Percent_Identity=22.972972972973, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=218, Percent_Identity=25.2293577981651, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323935, Length=238, Percent_Identity=26.0504201680672, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51258; Mature: 51258

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPEYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSAYLLGYAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
PLLITGRLGDQFGPRSMYLSGLAVFTAASLWCGLAGSIGWLIAARVVQGIGAAMLTPQTL
HHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHH
TVVQRVFPPERRGTAMGVWGAVAGIATLVGPVAGGLLVDGWGWQWIFYVNVPVGVLGIIL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCHHHHHHHH
GAIYIPRMPTHRHRLDLLGMALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
VWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTKAA
HHHHCCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
LTQAPTAIVSGILAPLAGWLVDRVRPSILIGGGIALMIASTLWWTLLMRPETQMWQLMLP
HHHCHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AAGIGAAMACIWGPLATTATRNLPPSVAGAGSGVYNTLRQVGGVVGSSAMGALMTARLTA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
TMPAMPPGSGSTPEAALPPGLRAPFSAAMAQSMLLGIAALALGLVAALFMRPGGSQVGAV
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PLDDVVSVED
CCCCCCCCCC
>Mature Secondary Structure
MRPEYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSAYLLGYAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
PLLITGRLGDQFGPRSMYLSGLAVFTAASLWCGLAGSIGWLIAARVVQGIGAAMLTPQTL
HHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHH
TVVQRVFPPERRGTAMGVWGAVAGIATLVGPVAGGLLVDGWGWQWIFYVNVPVGVLGIIL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCHHHHHHHH
GAIYIPRMPTHRHRLDLLGMALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
VWWQSANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTKAA
HHHHCCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
LTQAPTAIVSGILAPLAGWLVDRVRPSILIGGGIALMIASTLWWTLLMRPETQMWQLMLP
HHHCHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AAGIGAAMACIWGPLATTATRNLPPSVAGAGSGVYNTLRQVGGVVGSSAMGALMTARLTA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
TMPAMPPGSGSTPEAALPPGLRAPFSAAMAQSMLLGIAALALGLVAALFMRPGGSQVGAV
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PLDDVVSVED
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]