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The map label for this gene is ydgK [H]

Identifier: 169628486

GI number: 169628486

Start: 1395003

End: 1396286

Strand: Direct

Name: ydgK [H]

Synonym: MAB_1395

Alternate gene names: 169628486

Gene position: 1395003-1396286 (Clockwise)

Preceding gene: 169628482

Following gene: 169628487

Centisome position: 27.53

GC content: 65.89

Gene sequence:

>1284_bases
GTGCGTGCGCTGAGCACTGAGGTGACGAGTGCCCCCGGTAAGACGACAGTCGATGACCCGGCGACCGATCGCACTCCTGC
CGGTTCGGTCTCGCCTCCGGCAACCCGCCTGGGTCGGGCATGGCTCATCACCGTGCTGGGCGCCATGGTTGCCCTGGGCC
CCCTCACCATCGACATGTACCTGCCGGCCCTGCCCGACATCGGCTCGGATCTGCACGTCAACTCCACCCTCACCCAGCTG
ACACTGACCGGAACGCTGGTGGGGTTGGGTCTGGGGCAGCTGCTGGTGGGCCCGCTGTCGGATTCACTCGGCAGGCGGCT
GCCGCTGATCGCCGGGGCGATCCTGCACATCGTGGCGTCACTGGCCATCACCATCGCCCCGAACATCGTGGTGCTCGGCG
TGTTGCGGGCGGTCGAAGGGATGGGCGCCGCGGCGGCCATGGTGGTGGCGATGGCCGTGGTGCGTGACCTCTATACCGAT
AAGGCCGCGGCAACCGTGATCTCCCGGCTCACACTCGTCATTGGTATTGCGCCGATCCTGGCTCCGTCACTGGGCGCGGC
CGTGCTGGTGCATGGGTCATGGCAGAACGTATTCGCGGCCCTGTCATGCCTGGGCGTCCTGCTGCTCATCCTCGCCGTGG
TGGCGCTGCCGGAAACACTGCCCCCGTCTGCGCGACGTCCACTGCGGGCAGGGGCCATCCTGCGGACTTACCGCGATCTG
CTGCGCGACAAGGTGTTCGTGGTTCTGGTGCTGGTTGCCGGTCTTTCGTTGTCCGGTCTGTTCGCCTACATCTCGGGTGC
CTCGTTTGTGTTGCAGGGACAGTACGGCATGAATCAACAGGTGTTCGCGCTCGCATTCGGTGCGGGTGCCATCGCGTTTG
TGGCTGCCTCACAGCTGAACGTCGTGCTGCTCAAGCGATTCGAACCGCAGCAGATCGTGCGGTGGTGCTTGTCGCTGGCT
TTGATCCCGGCGGTGGTGCTACTGGTGCTGGCGGGTTTCGGTATCGGTGGGCTCGTCGGCTTTGTGGCTCCGGTGTGGAC
GTTGATGGCATTGATGGGCTTCGTCATACCGAACGCGCCTGCGCTGGCGTTGTCCCGCCACGGTGAGGCGGCGGGTACTT
CGGCTGCGGTGCTGGGCGCCGCACAATTCGGGGTGGGTGCCGTGATCGCGCCGCTGGTTGGGGCATTGGGCAACAACGCG
CTGGCCGTCGCCATCGTCATGATGATCGGAGTGGTGCTGGCTCTGGCCGGGCTGGCCGTCGTGAGAAATCGTGTCGCTGC
CTGA

Upstream 100 bases:

>100_bases
CCGGTAATGGGGGCGATGTCTCCTCCTGGATGGGAGTGGAGACTTGACCGATTGAGTGAGACGCAGCTCACATTTGTTAG
GGAAGGGAAGGTTTTGCCAC

Downstream 100 bases:

>100_bases
CCGACGACTAAGTTCCGTAGCCGTGCGACCTGAATATCCGCGACCGTGGATCACCTTGTGGGTGGTGCTGTTCGGGTTGT
TCATGATCTTGCTCGACTCG

Product: Bcr/CflA family multidrug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPATRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQL
TLTGTLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGVLRAVEGMGAAAAMVVAMAVVRDLYTD
KAAATVISRLTLVIGIAPILAPSLGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLRAGAILRTYRDL
LRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQVFALAFGAGAIAFVAASQLNVVLLKRFEPQQIVRWCLSLA
LIPAVVLLVLAGFGIGGLVGFVAPVWTLMALMGFVIPNAPALALSRHGEAAGTSAAVLGAAQFGVGAVIAPLVGALGNNA
LAVAIVMMIGVVLALAGLAVVRNRVAA

Sequences:

>Translated_427_residues
MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPATRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQL
TLTGTLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGVLRAVEGMGAAAAMVVAMAVVRDLYTD
KAAATVISRLTLVIGIAPILAPSLGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLRAGAILRTYRDL
LRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQVFALAFGAGAIAFVAASQLNVVLLKRFEPQQIVRWCLSLA
LIPAVVLLVLAGFGIGGLVGFVAPVWTLMALMGFVIPNAPALALSRHGEAAGTSAAVLGAAQFGVGAVIAPLVGALGNNA
LAVAIVMMIGVVLALAGLAVVRNRVAA
>Mature_427_residues
MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPATRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQL
TLTGTLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGVLRAVEGMGAAAAMVVAMAVVRDLYTD
KAAATVISRLTLVIGIAPILAPSLGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLRAGAILRTYRDL
LRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQVFALAFGAGAIAFVAASQLNVVLLKRFEPQQIVRWCLSLA
LIPAVVLLVLAGFGIGGLVGFVAPVWTLMALMGFVIPNAPALALSRHGEAAGTSAAVLGAAQFGVGAVIAPLVGALGNNA
LAVAIVMMIGVVLALAGLAVVRNRVAA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=352, Percent_Identity=31.8181818181818, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI48994889, Length=391, Percent_Identity=30.690537084399, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790146, Length=239, Percent_Identity=31.3807531380753, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790794, Length=193, Percent_Identity=26.9430051813472, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082312, Length=216, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787065, Length=208, Percent_Identity=27.8846153846154, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789207, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=221, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321838, Length=269, Percent_Identity=21.9330855018587, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43434; Mature: 43434

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCC
>Mature Secondary Structure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HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]