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The map label for this gene is caiC [H]

Identifier: 169628435

GI number: 169628435

Start: 1343322

End: 1345112

Strand: Direct

Name: caiC [H]

Synonym: MAB_1342

Alternate gene names: 169628435

Gene position: 1343322-1345112 (Clockwise)

Preceding gene: 169628434

Following gene: 169628436

Centisome position: 26.51

GC content: 63.04

Gene sequence:

>1791_bases
ATGTCCGCAAGCAGCACCATCCCGTCGAATCCGCGTGATCGCGTCCGGTTGACCGATGTGCTCGCGCAGCTGCCCGGTTT
GGCGCTCGACCTGCCGATCATGGCGCGGGGCATCCTCAGCGGCATCAAGTCCACGCCCAAGGGGCGGTGGTCGATCGGCG
GGGTGTTTGCCGAACGCGCCGCCAAACACGCAGACCGAGTGTTCTTGCGTTTCGAGGGCCAGGACATCACCTACGCGCAG
GCCAACGCCACCGCCAATCGGTACGCCGCCACCCTGGCCTCGCAGGGGGTGGGGCGTGGCGACGTGGTCGGCATCATGCT
GCGCAACTCTCCCGAGACAGTGCTGTTGATGTTGGCGACCGTCAAGCTCGGTGCCATCGCGGGCATGCTCAACTACAACC
AGCGTGGCCATGTGCTGGCCCACAGCATCGGGTTGCTTGATTCCAAACTACTGATCACCGAGGCGGAGTTCGAGGAAGCC
ATCAGCGAATCCGGCGTCAATGTGGTCTCGCAGCTGACCATCGACGAGCTGGACCGGATGTCGGTTTTGGCGCCTACCGC
CAATCCGAGTGCCACCGAAGCGGTGATGACCAAGGATCGCGCGTTCTACATTTTCACCTCGGGCACCACCGGCCTGCCCA
AGGCCAGCGTGATGACGCACTACCGCTGGTTGCGGGGTATGTCGGGTATCGGCGACATGGCGTTGCGGTTGCGGCCTGAC
GATGTGCTGTACAGCTGCTTGCCGTTGTATCACAACAACGCGTTGACCCTGGCCGTGTCCACCACCGTCAATGCCGGAGC
TACCCTGGCGATCGGCCGGTCGTTCTCGGTGTCGCGGTTCTGGGACGAGGTGATTGCCAGTCGTGCAACGGCTTTCATTT
ACATCGGAGAATTGTGCCGTTATCTGCTCAATCAGCCGCCGAAGCCCACCGATCGCAAACACAGGGTGCGCGTCATCGTC
GGTAACGGCCTGCGGCCGGAGCTGTGGGGCGAATTCACCGCGCGATTCGGGATCAAGCGGGTCTGTGAGTTCTACTCGGC
CAGCGAGTCGAACACCGCATTTGTCAACGCGCTCAATATCGACCGCACCGTGGGCATCTGTCCGATGCCCATCGCGTACG
TCAAGTACGACGTCGAGAGTGGTGAACCGGTACGTAACGACAAGGGTTTCCTGACCAAGGTCGGGCCTGGGGAGTCGGGA
CTGCTGCTGAGCAAGGTGACCGACCTGGCGCCGTTCGACGGGTACACCGACCCGACGGCCTCGGAGAAGAAGCTGGTGCG
TGACGCCTTCAAGAAGGGCGACACCTGGTTCAACACAGGCGATCTGATGCGCAACCTCGGCTGGGGTCATGCGGCGTTCG
GTGACCGGCTCGGCGACACCTTCCGGTGGAAGGGTGAGAATGTGGCCACCACCGAGGTGGAGGCCGCGATCGAACACAAC
GACGCGGTGGAGGAGTCGACGGTCTTCGGCGTGCAGGTGCCCGGTACCGATGGTCGCGCCGGAATGGCCGCCATCAAGTT
GCACGATGGCGTCGAGCTCGATCCAAAGGCTCTGAGCGACACCGTGTATCAGAATCTTCCCGCGTACGCGCTGCCGCTGT
TCATTCGGATCGTGGACACCCTGGAGCACACCACCACCTTCAAGAGTCGCAAAGTGGAGCTGCGCGAGCAGGCGTACGGC
GAATCGGTGACCGATCCGCTGTACGTGCTGGCCGGCCGTGCGGAGGGATACGTTCCGTTCTATCCCGAGTACCCGGAGGA
ACTGGCGGGCGGACAGCGCCCCAAGGGTTAG

Upstream 100 bases:

>100_bases
GGGCCTGGCCGTTCGTCAACAATGCGGTGAGCCATTGCCTACTCGGCGGTAAGAACAGGGATGACCCGCTCGCGGGACGA
CCGACAACAGGGAGAACTAG

Downstream 100 bases:

>100_bases
CGCGTCGTAAACCGGCGCGGCTGGCTTGCCGGGATAACGTTCGAGGCATGGCCGGAACTCGTCGTGCGCGGATAGCGAAA
CGCCGCCGCCTACGGGTAAG

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MSASSTIPSNPRDRVRLTDVLAQLPGLALDLPIMARGILSGIKSTPKGRWSIGGVFAERAAKHADRVFLRFEGQDITYAQ
ANATANRYAATLASQGVGRGDVVGIMLRNSPETVLLMLATVKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLITEAEFEEA
ISESGVNVVSQLTIDELDRMSVLAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGDMALRLRPD
DVLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWDEVIASRATAFIYIGELCRYLLNQPPKPTDRKHRVRVIV
GNGLRPELWGEFTARFGIKRVCEFYSASESNTAFVNALNIDRTVGICPMPIAYVKYDVESGEPVRNDKGFLTKVGPGESG
LLLSKVTDLAPFDGYTDPTASEKKLVRDAFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIEHN
DAVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPAYALPLFIRIVDTLEHTTTFKSRKVELREQAYG
ESVTDPLYVLAGRAEGYVPFYPEYPEELAGGQRPKG

Sequences:

>Translated_596_residues
MSASSTIPSNPRDRVRLTDVLAQLPGLALDLPIMARGILSGIKSTPKGRWSIGGVFAERAAKHADRVFLRFEGQDITYAQ
ANATANRYAATLASQGVGRGDVVGIMLRNSPETVLLMLATVKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLITEAEFEEA
ISESGVNVVSQLTIDELDRMSVLAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGDMALRLRPD
DVLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWDEVIASRATAFIYIGELCRYLLNQPPKPTDRKHRVRVIV
GNGLRPELWGEFTARFGIKRVCEFYSASESNTAFVNALNIDRTVGICPMPIAYVKYDVESGEPVRNDKGFLTKVGPGESG
LLLSKVTDLAPFDGYTDPTASEKKLVRDAFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIEHN
DAVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPAYALPLFIRIVDTLEHTTTFKSRKVELREQAYG
ESVTDPLYVLAGRAEGYVPFYPEYPEELAGGQRPKG
>Mature_595_residues
SASSTIPSNPRDRVRLTDVLAQLPGLALDLPIMARGILSGIKSTPKGRWSIGGVFAERAAKHADRVFLRFEGQDITYAQA
NATANRYAATLASQGVGRGDVVGIMLRNSPETVLLMLATVKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLITEAEFEEAI
SESGVNVVSQLTIDELDRMSVLAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGDMALRLRPDD
VLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWDEVIASRATAFIYIGELCRYLLNQPPKPTDRKHRVRVIVG
NGLRPELWGEFTARFGIKRVCEFYSASESNTAFVNALNIDRTVGICPMPIAYVKYDVESGEPVRNDKGFLTKVGPGESGL
LLSKVTDLAPFDGYTDPTASEKKLVRDAFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIEHND
AVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPAYALPLFIRIVDTLEHTTTFKSRKVELREQAYGE
SVTDPLYVLAGRAEGYVPFYPEYPEELAGGQRPKG

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=578, Percent_Identity=41.1764705882353, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI40807357, Length=581, Percent_Identity=37.0051635111876, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI62865631, Length=559, Percent_Identity=37.0304114490161, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI13325055, Length=559, Percent_Identity=37.0304114490161, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI38524616, Length=536, Percent_Identity=38.2462686567164, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI227499621, Length=563, Percent_Identity=37.8330373001776, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI13325057, Length=573, Percent_Identity=36.4746945898778, Blast_Score=339, Evalue=6e-93,
Organism=Homo sapiens, GI13236579, Length=523, Percent_Identity=37.093690248566, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI28416953, Length=577, Percent_Identity=23.3968804159445, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI187761345, Length=526, Percent_Identity=23.574144486692, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI187761343, Length=526, Percent_Identity=23.574144486692, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI221142682, Length=504, Percent_Identity=26.984126984127, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788107, Length=562, Percent_Identity=22.0640569395018, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551278, Length=592, Percent_Identity=34.2905405405405, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI115534440, Length=551, Percent_Identity=35.2087114337568, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI32563687, Length=495, Percent_Identity=23.8383838383838, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319515, Length=562, Percent_Identity=30.4270462633452, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6319699, Length=495, Percent_Identity=22.8282828282828, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583465, Length=576, Percent_Identity=37.8472222222222, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24583463, Length=576, Percent_Identity=37.8472222222222, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281364798, Length=576, Percent_Identity=37.8472222222222, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI45550496, Length=587, Percent_Identity=37.3083475298126, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI45552801, Length=587, Percent_Identity=37.3083475298126, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI20130353, Length=578, Percent_Identity=35.6401384083045, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI28573631, Length=578, Percent_Identity=35.6401384083045, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI21355181, Length=471, Percent_Identity=22.0806794055202, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 64997; Mature: 64866

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSTIPSNPRDRVRLTDVLAQLPGLALDLPIMARGILSGIKSTPKGRWSIGGVFAERA
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
AKHADRVFLRFEGQDITYAQANATANRYAATLASQGVGRGDVVGIMLRNSPETVLLMLAT
HHHCCEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEHHHHH
VKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLITEAEFEEAISESGVNVVSQLTIDELDRM
HHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCC
SVLAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGDMALRLRPD
EEECCCCCCCHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCH
DVLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWDEVIASRATAFIYIGELCR
HHHHHHHHHHCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEHHHHHH
YLLNQPPKPTDRKHRVRVIVGNGLRPELWGEFTARFGIKRVCEFYSASESNTAFVNALNI
HHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
DRTVGICPMPIAYVKYDVESGEPVRNDKGFLTKVGPGESGLLLSKVTDLAPFDGYTDPTA
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCEEHHHHHHCCCCCCCCCCCC
SEKKLVRDAFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIEHN
HHHHHHHHHHHCCCCEECHHHHHHHCCCCCHHHHHHCCCCEEECCCCEEEHHHHHHHHCC
DAVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPAYALPLFIRIVDT
CCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
LEHTTTFKSRKVELREQAYGESVTDPLYVLAGRAEGYVPFYPEYPEELAGGQRPKG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
SASSTIPSNPRDRVRLTDVLAQLPGLALDLPIMARGILSGIKSTPKGRWSIGGVFAERA
CCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
AKHADRVFLRFEGQDITYAQANATANRYAATLASQGVGRGDVVGIMLRNSPETVLLMLAT
HHHCCEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEHHHHH
VKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLITEAEFEEAISESGVNVVSQLTIDELDRM
HHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCC
SVLAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGDMALRLRPD
EEECCCCCCCHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCH
DVLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWDEVIASRATAFIYIGELCR
HHHHHHHHHHCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEHHHHHH
YLLNQPPKPTDRKHRVRVIVGNGLRPELWGEFTARFGIKRVCEFYSASESNTAFVNALNI
HHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
DRTVGICPMPIAYVKYDVESGEPVRNDKGFLTKVGPGESGLLLSKVTDLAPFDGYTDPTA
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCEEHHHHHHCCCCCCCCCCCC
SEKKLVRDAFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIEHN
HHHHHHHHHHHCCCCEECHHHHHHHCCCCCHHHHHHCCCCEEECCCCEEEHHHHHHHHCC
DAVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPAYALPLFIRIVDT
CCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
LEHTTTFKSRKVELREQAYGESVTDPLYVLAGRAEGYVPFYPEYPEELAGGQRPKG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA