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The map label for this gene is lysA [H]

Identifier: 169628249

GI number: 169628249

Start: 1167616

End: 1168962

Strand: Reverse

Name: lysA [H]

Synonym: MAB_1156c

Alternate gene names: 169628249

Gene position: 1168962-1167616 (Counterclockwise)

Preceding gene: 169628254

Following gene: 169628241

Centisome position: 23.07

GC content: 68.6

Gene sequence:

>1347_bases
ATGACACTTCTGGACCTCCTGCCGTCCTTACACAATGTGGCTCGCCCACGCGTCGACCCGGCCGTGTGGCCGGTCACCAC
ACACCTGGATGAGCAGGGCCGGATGTGCGTCGGAGAGACGGCGCTCTCGGAGATCGCCGACCAATTCCGCACCCCCGCGT
ACGTGCTCGACGAGGAGGATTTCCGTCATCGCGCCCGCCGCTACCGCAGCACCCTGCGCGAGATCGAGGTCGCATACGCC
GGCAAGGCGCTGCTGACGGCCGATATCGCGCGCTGGGTGGCACAAGAGGGCCTGTCACTGGATGTCTGCTCCTCCGGCGA
GCTGGCCACCGCCCTCGCGGGCGGTTTCGATCCGGAACGAATCATCATGCACGGCAATGCCAAGACCCCCGATGAACTCA
GTGACGCGGCTGCCGTGGGCGTGGGCCGGATCGTGGTGGATTCCTACACCGAGATCATGTTCCTGGCGACCCGCCTCGCG
AAGCGCCAGCGCGTGCTGGTGCGGGTCACCCCCGATATCGACATCCACGGACATGCGGCGGTGACGACGGGGGTCACGGA
TCAGAAGTTCGGCTTCCCGCTGCATGAGGGCCACGCCATCGAAGCTGCCCGCCGCGTGCTGGATCAGCCCTTGCTGAACC
TGGTGGGCCTGCACTGCCACATCGGCTCGCAGGTCACCGACTGTGCGCTGTACGGCGAGACCATCCGCCGCATGATCGCG
GCGATGGCCGACATCCGGGCCAGGCACGGCGTGATCCTGGGTGAGCTCAATATCGGTGGCGGCCACGGCGTTCCCTACCG
TTCGGGCGACCCCGAACTCGATCTCGCCGAGCTGCGCGACTTCATCGACGACGCCCTGGACGCCGCCTGCGCGGCCGAGC
GCTTCCCGCGCCCGCGTGTGGTCGTCGAGCCCGGCCGCGCGATCTCCGCACGCGCGGGCGTCACGCTCTACCGGGTGGTA
TCGGTCAAGACCCAGCCCGGTGGCCGCACCTTCGTCGCCGTCGACGGTGGCATGAGTGACAACCCCCGCGTTTCCCTGTA
TAGCGCGAAATACAGTGTCGCGCTGGCCAACCGCCACCCGTCCGCCCCGCCACAGCTGGTGACGGTGGCCGGGCGGCACT
GCGAATCCGGCGATGAGATCGCCCGGGATGTCAGTCTGCCCTCCGATGTGCGCCCCGGCGACGTTCTTGCCGTCGCCTGC
ACCGGCGCGTACCACCACAGCATGGCCTCGTCCTACAACCTGGTCGGGCGTCCGCCCGTGGTCGCCGTACGCGATGGACG
CGTGCGCGAGCTGGTACGCCGCGAGACGATTGCCGATCTGCTCTCGCGGGACCGCGGCGCGCGCTAG

Upstream 100 bases:

>100_bases
TAGGGCTACGGCGCCCAGATCCCGACAAAATCGGGCCCATCGCCGTCAAGGCCACGTCAAGAAACTCCGCACCAGGTCGC
CACGAGAGCACGGTGGATGC

Downstream 100 bases:

>100_bases
GGCCAGTGAGCGGTGGGCATGGGTTTGGTCTGTTCTACCGTCAGCGGCGGTGTGGCCTCATGCTCGGGATCGGGAGTCGA
GTGGATCTCGGCATTTCCCG

Product: diaminopimelate decarboxylase LysA

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTLLDLLPSLHNVARPRVDPAVWPVTTHLDEQGRMCVGETALSEIADQFRTPAYVLDEEDFRHRARRYRSTLREIEVAYA
GKALLTADIARWVAQEGLSLDVCSSGELATALAGGFDPERIIMHGNAKTPDELSDAAAVGVGRIVVDSYTEIMFLATRLA
KRQRVLVRVTPDIDIHGHAAVTTGVTDQKFGFPLHEGHAIEAARRVLDQPLLNLVGLHCHIGSQVTDCALYGETIRRMIA
AMADIRARHGVILGELNIGGGHGVPYRSGDPELDLAELRDFIDDALDAACAAERFPRPRVVVEPGRAISARAGVTLYRVV
SVKTQPGGRTFVAVDGGMSDNPRVSLYSAKYSVALANRHPSAPPQLVTVAGRHCESGDEIARDVSLPSDVRPGDVLAVAC
TGAYHHSMASSYNLVGRPPVVAVRDGRVRELVRRETIADLLSRDRGAR

Sequences:

>Translated_448_residues
MTLLDLLPSLHNVARPRVDPAVWPVTTHLDEQGRMCVGETALSEIADQFRTPAYVLDEEDFRHRARRYRSTLREIEVAYA
GKALLTADIARWVAQEGLSLDVCSSGELATALAGGFDPERIIMHGNAKTPDELSDAAAVGVGRIVVDSYTEIMFLATRLA
KRQRVLVRVTPDIDIHGHAAVTTGVTDQKFGFPLHEGHAIEAARRVLDQPLLNLVGLHCHIGSQVTDCALYGETIRRMIA
AMADIRARHGVILGELNIGGGHGVPYRSGDPELDLAELRDFIDDALDAACAAERFPRPRVVVEPGRAISARAGVTLYRVV
SVKTQPGGRTFVAVDGGMSDNPRVSLYSAKYSVALANRHPSAPPQLVTVAGRHCESGDEIARDVSLPSDVRPGDVLAVAC
TGAYHHSMASSYNLVGRPPVVAVRDGRVRELVRRETIADLLSRDRGAR
>Mature_447_residues
TLLDLLPSLHNVARPRVDPAVWPVTTHLDEQGRMCVGETALSEIADQFRTPAYVLDEEDFRHRARRYRSTLREIEVAYAG
KALLTADIARWVAQEGLSLDVCSSGELATALAGGFDPERIIMHGNAKTPDELSDAAAVGVGRIVVDSYTEIMFLATRLAK
RQRVLVRVTPDIDIHGHAAVTTGVTDQKFGFPLHEGHAIEAARRVLDQPLLNLVGLHCHIGSQVTDCALYGETIRRMIAA
MADIRARHGVILGELNIGGGHGVPYRSGDPELDLAELRDFIDDALDAACAAERFPRPRVVVEPGRAISARAGVTLYRVVS
VKTQPGGRTFVAVDGGMSDNPRVSLYSAKYSVALANRHPSAPPQLVTVAGRHCESGDEIARDVSLPSDVRPGDVLAVACT
GAYHHSMASSYNLVGRPPVVAVRDGRVRELVRRETIADLLSRDRGAR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=416, Percent_Identity=25.9615384615385, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789203, Length=418, Percent_Identity=31.1004784688995, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562780, Length=424, Percent_Identity=22.1698113207547, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=383, Percent_Identity=20.3655352480418, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48550; Mature: 48419

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLDLLPSLHNVARPRVDPAVWPVTTHLDEQGRMCVGETALSEIADQFRTPAYVLDEED
CCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECHHHHHHHHHHHCCCEEEECCHH
FRHRARRYRSTLREIEVAYAGKALLTADIARWVAQEGLSLDVCSSGELATALAGGFDPER
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCE
IIMHGNAKTPDELSDAAAVGVGRIVVDSYTEIMFLATRLAKRQRVLVRVTPDIDIHGHAA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCEE
VTTGVTDQKFGFPLHEGHAIEAARRVLDQPLLNLVGLHCHIGSQVTDCALYGETIRRMIA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
AMADIRARHGVILGELNIGGGHGVPYRSGDPELDLAELRDFIDDALDAACAAERFPRPRV
HHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCE
VVEPGRAISARAGVTLYRVVSVKTQPGGRTFVAVDGGMSDNPRVSLYSAKYSVALANRHP
EECCCCCEECCCCEEEEEEEEEEECCCCEEEEEECCCCCCCCCEEEEECEEEEEEECCCC
SAPPQLVTVAGRHCESGDEIARDVSLPSDVRPGDVLAVACTGAYHHSMASSYNLVGRPPV
CCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCE
VAVRDGRVRELVRRETIADLLSRDRGAR
EEECCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLLDLLPSLHNVARPRVDPAVWPVTTHLDEQGRMCVGETALSEIADQFRTPAYVLDEED
CHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECHHHHHHHHHHHCCCEEEECCHH
FRHRARRYRSTLREIEVAYAGKALLTADIARWVAQEGLSLDVCSSGELATALAGGFDPER
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCE
IIMHGNAKTPDELSDAAAVGVGRIVVDSYTEIMFLATRLAKRQRVLVRVTPDIDIHGHAA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCEE
VTTGVTDQKFGFPLHEGHAIEAARRVLDQPLLNLVGLHCHIGSQVTDCALYGETIRRMIA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
AMADIRARHGVILGELNIGGGHGVPYRSGDPELDLAELRDFIDDALDAACAAERFPRPRV
HHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCE
VVEPGRAISARAGVTLYRVVSVKTQPGGRTFVAVDGGMSDNPRVSLYSAKYSVALANRHP
EECCCCCEECCCCEEEEEEEEEEECCCCEEEEEECCCCCCCCCEEEEECEEEEEEECCCC
SAPPQLVTVAGRHCESGDEIARDVSLPSDVRPGDVLAVACTGAYHHSMASSYNLVGRPPV
CCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCE
VAVRDGRVRELVRRETIADLLSRDRGAR
EEECCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA