| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is purH [H]
Identifier: 169628159
GI number: 169628159
Start: 1073939
End: 1075519
Strand: Direct
Name: purH [H]
Synonym: MAB_1064
Alternate gene names: 169628159
Gene position: 1073939-1075519 (Clockwise)
Preceding gene: 169628158
Following gene: 169628160
Centisome position: 21.19
GC content: 66.48
Gene sequence:
>1581_bases ATGGAACGGAAGAAGGGCCTCCATCAAGTGAGTACGCAGCGACCCGTACGTCGGGCATTGATCAGCGTTTACGACAAGAC CGGGCTGGAGGAGCTCGCCAGCGGTCTCCATGCGGCCGGTGTGGAGCTGGTATCCACCGGATCCACGGCGAAGACCATTG CGGCTGCGTCAATTCCAGTGACGCCTGTGGAGGATGTCACGGGTTTTCCGGAGGTGCTGGACGGCCGGGTGAAGACTCTG CACCCGCATGTGCACGCCGGCGTGCTGGCCGACACCCGCCGCGAAGAGCACCTCACCCAGCTCGAAGAGCTAGGGGTGCA GGGCTTCGAGCTGGTGGTGGTCAACCTGTATCCGTTCGCGGCCACGGTGGCCTCGGGCGCCTCGGAAGACGAATGCGTCG AGCAGATAGATATCGGCGGACCTTCGATGGTGCGCGCCGCGGCCAAGAACCACCCGAGCGTCGCGGTTGTCGTCGATCCG GCCGCGTACGGCGAGGTGCTGGCCGCGGTCACCGCCGGAGGCTTCACCCTGGAGGCGCGGAAGGTTTTGGCTGCCAAGGC GTTCCGGCACACCGCAGAATACGATGTGGCGGTCGCGGGGTGGCTCTCCGGTGTGGCAGAGCCCGGGGACGCCGAGCTGC CCTCATGGATCGGCGGCACGTGGAACCGTTCGGCGGTGCTGCGCTATGGAGAGAACCCGCACCAGCAGGCGGCCCTGTAT ATCGGTGCCGCCGGGCAGGGCCTTGCTCAGGCCGAGCAGCTGCACGGAAAAGAGATGTCGTACAACAACTACACCGACGC CGACGCCGCGTGGCGTGCCGCATGGGATCAGGACAAGGCATGCGCGGCGATCATCAAGCACGCCAACCCATGTGGTATCG CGGTGTCGGACATCTCGATTGCCGATGCGCACCTCAAGGCGCACGAATGCGATCCATTGAGTGCGTTCGGCGGCGTGATC GCCGTCAACCGTGAGGTGAGTGTGGAGATGGCCGAGCGGGTGGCCGACATCTTCACCGAGGTGATCGTGGCCCCGGGGTA CGCCGATGGCGCCGTCGAGGTGCTGAGCCGCAAGAAGAACGTGCGGCTGCTGCGTGCCGCACAACCCGAGTCGGGCAGCA CCGAGTGGCGCCAGATCAGCGGTGGCCTGCTGGTCCAGGAGCGCGATGCGCTGGATGCGGAGGGCGACGATCCGGCCAAC TGGACGTTGGTGGCCGGAGCCGCTGCCGATGCGGACACTCTGGCGGATTTGGTTTTCGCGTGGAAGGTGGGGCGGGCCGT CAAGTCGAACGCGATTGTCATCGCCTCGGGCGGTGCCACCATCGGTGTGGGCATGGGACAGGTCAACCGGGTTGATGCCG CGCGGCTCGCGGTTTCGCGTGGCGGAGACCGGGTCAGCGGTGCCGTCGCTGCCTCGGATGCGTTCTTCCCCTTCCCCGAC GGCCTGGAGGTACTGAGCCAGGCCGGTGTGCGCGCGGTTGTTCATCCGGGCGGTTCGATGCGCGATGAGTTGGTAACCGA CGCCGCCAAGGCGGCGGGTATCACCCTCTACACCACCGGAGCACGCCACTTCGCCCACTAA
Upstream 100 bases:
>100_bases ACCGGGACGACGACGAGGCGAGTCTGCATGAACGCATCAAGGTAGTGGAACGGACCCTGCTGGTAGATGTGCTGGCCGCG GTGGCCACCAAAGGTTTGAC
Downstream 100 bases:
>100_bases GGCGCATCACGAGGGAGAGCCGATGGTTCAGCCCAGTTTGGATTGGCCGGGCGAGCCACTGCGCTCGCTGGTGTGGACCC TGCAGGCCTGGGCCGTCACC
Product: bifunctional phospho ribosylaminoimidazole carboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 526; Mature: 526
Protein sequence:
>526_residues MERKKGLHQVSTQRPVRRALISVYDKTGLEELASGLHAAGVELVSTGSTAKTIAAASIPVTPVEDVTGFPEVLDGRVKTL HPHVHAGVLADTRREEHLTQLEELGVQGFELVVVNLYPFAATVASGASEDECVEQIDIGGPSMVRAAAKNHPSVAVVVDP AAYGEVLAAVTAGGFTLEARKVLAAKAFRHTAEYDVAVAGWLSGVAEPGDAELPSWIGGTWNRSAVLRYGENPHQQAALY IGAAGQGLAQAEQLHGKEMSYNNYTDADAAWRAAWDQDKACAAIIKHANPCGIAVSDISIADAHLKAHECDPLSAFGGVI AVNREVSVEMAERVADIFTEVIVAPGYADGAVEVLSRKKNVRLLRAAQPESGSTEWRQISGGLLVQERDALDAEGDDPAN WTLVAGAAADADTLADLVFAWKVGRAVKSNAIVIASGGATIGVGMGQVNRVDAARLAVSRGGDRVSGAVAASDAFFPFPD GLEVLSQAGVRAVVHPGGSMRDELVTDAAKAAGITLYTTGARHFAH
Sequences:
>Translated_526_residues MERKKGLHQVSTQRPVRRALISVYDKTGLEELASGLHAAGVELVSTGSTAKTIAAASIPVTPVEDVTGFPEVLDGRVKTL HPHVHAGVLADTRREEHLTQLEELGVQGFELVVVNLYPFAATVASGASEDECVEQIDIGGPSMVRAAAKNHPSVAVVVDP AAYGEVLAAVTAGGFTLEARKVLAAKAFRHTAEYDVAVAGWLSGVAEPGDAELPSWIGGTWNRSAVLRYGENPHQQAALY IGAAGQGLAQAEQLHGKEMSYNNYTDADAAWRAAWDQDKACAAIIKHANPCGIAVSDISIADAHLKAHECDPLSAFGGVI AVNREVSVEMAERVADIFTEVIVAPGYADGAVEVLSRKKNVRLLRAAQPESGSTEWRQISGGLLVQERDALDAEGDDPAN WTLVAGAAADADTLADLVFAWKVGRAVKSNAIVIASGGATIGVGMGQVNRVDAARLAVSRGGDRVSGAVAASDAFFPFPD GLEVLSQAGVRAVVHPGGSMRDELVTDAAKAAGITLYTTGARHFAH >Mature_526_residues MERKKGLHQVSTQRPVRRALISVYDKTGLEELASGLHAAGVELVSTGSTAKTIAAASIPVTPVEDVTGFPEVLDGRVKTL HPHVHAGVLADTRREEHLTQLEELGVQGFELVVVNLYPFAATVASGASEDECVEQIDIGGPSMVRAAAKNHPSVAVVVDP AAYGEVLAAVTAGGFTLEARKVLAAKAFRHTAEYDVAVAGWLSGVAEPGDAELPSWIGGTWNRSAVLRYGENPHQQAALY IGAAGQGLAQAEQLHGKEMSYNNYTDADAAWRAAWDQDKACAAIIKHANPCGIAVSDISIADAHLKAHECDPLSAFGGVI AVNREVSVEMAERVADIFTEVIVAPGYADGAVEVLSRKKNVRLLRAAQPESGSTEWRQISGGLLVQERDALDAEGDDPAN WTLVAGAAADADTLADLVFAWKVGRAVKSNAIVIASGGATIGVGMGQVNRVDAARLAVSRGGDRVSGAVAASDAFFPFPD GLEVLSQAGVRAVVHPGGSMRDELVTDAAKAAGITLYTTGARHFAH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=476, Percent_Identity=35.5042016806723, Blast_Score=230, Evalue=2e-60, Organism=Escherichia coli, GI1790439, Length=535, Percent_Identity=44.8598130841121, Blast_Score=422, Evalue=1e-119, Organism=Caenorhabditis elegans, GI71985564, Length=475, Percent_Identity=37.0526315789474, Blast_Score=226, Evalue=2e-59, Organism=Caenorhabditis elegans, GI71985574, Length=306, Percent_Identity=28.7581699346405, Blast_Score=77, Evalue=2e-14, Organism=Caenorhabditis elegans, GI71985556, Length=141, Percent_Identity=35.4609929078014, Blast_Score=70, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6323056, Length=474, Percent_Identity=35.6540084388186, Blast_Score=231, Evalue=2e-61, Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=34.2436974789916, Blast_Score=221, Evalue=3e-58, Organism=Drosophila melanogaster, GI24649832, Length=468, Percent_Identity=35.4700854700855, Blast_Score=223, Evalue=3e-58,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 54957; Mature: 54957
Theoretical pI: Translated: 5.13; Mature: 5.13
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MERKKGLHQVSTQRPVRRALISVYDKTGLEELASGLHAAGVELVSTGSTAKTIAAASIPV CCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHCCHHHCCEEEEECCCCHHHEEECCCCC TPVEDVTGFPEVLDGRVKTLHPHVHAGVLADTRREEHLTQLEELGVQGFELVVVNLYPFA CCHHHCCCCHHHHCCCCEEECCCHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHH ATVASGASEDECVEQIDIGGPSMVRAAAKNHPSVAVVVDPAAYGEVLAAVTAGGFTLEAR HHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCEEHHHH KVLAAKAFRHTAEYDVAVAGWLSGVAEPGDAELPSWIGGTWNRSAVLRYGENPHQQAALY HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEECCCCCCCEEEE IGAAGQGLAQAEQLHGKEMSYNNYTDADAAWRAAWDQDKACAAIIKHANPCGIAVSDISI EECCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCEE ADAHLKAHECDPLSAFGGVIAVNREVSVEMAERVADIFTEVIVAPGYADGAVEVLSRKKN EHHHHHCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC VRLLRAAQPESGSTEWRQISGGLLVQERDALDAEGDDPANWTLVAGAAADADTLADLVFA CEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH WKVGRAVKSNAIVIASGGATIGVGMGQVNRVDAARLAVSRGGDRVSGAVAASDAFFPFPD HHHHHHHCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC GLEVLSQAGVRAVVHPGGSMRDELVTDAAKAAGITLYTTGARHFAH HHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCEEEEECCCHHCCC >Mature Secondary Structure MERKKGLHQVSTQRPVRRALISVYDKTGLEELASGLHAAGVELVSTGSTAKTIAAASIPV CCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHCCHHHCCEEEEECCCCHHHEEECCCCC TPVEDVTGFPEVLDGRVKTLHPHVHAGVLADTRREEHLTQLEELGVQGFELVVVNLYPFA CCHHHCCCCHHHHCCCCEEECCCHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHH ATVASGASEDECVEQIDIGGPSMVRAAAKNHPSVAVVVDPAAYGEVLAAVTAGGFTLEAR HHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCEEHHHH KVLAAKAFRHTAEYDVAVAGWLSGVAEPGDAELPSWIGGTWNRSAVLRYGENPHQQAALY HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEECCCCCCCEEEE IGAAGQGLAQAEQLHGKEMSYNNYTDADAAWRAAWDQDKACAAIIKHANPCGIAVSDISI EECCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCEE ADAHLKAHECDPLSAFGGVIAVNREVSVEMAERVADIFTEVIVAPGYADGAVEVLSRKKN EHHHHHCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC VRLLRAAQPESGSTEWRQISGGLLVQERDALDAEGDDPANWTLVAGAAADADTLADLVFA CEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH WKVGRAVKSNAIVIASGGATIGVGMGQVNRVDAARLAVSRGGDRVSGAVAASDAFFPFPD HHHHHHHCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC GLEVLSQAGVRAVVHPGGSMRDELVTDAAKAAGITLYTTGARHFAH HHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCEEEEECCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA