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The map label for this gene is mutM [H]

Identifier: 169628133

GI number: 169628133

Start: 1047655

End: 1048518

Strand: Direct

Name: mutM [H]

Synonym: MAB_1038

Alternate gene names: 169628133

Gene position: 1047655-1048518 (Clockwise)

Preceding gene: 169628132

Following gene: 169628134

Centisome position: 20.68

GC content: 65.05

Gene sequence:

>864_bases
ATGCCCGAACTACCGGAAGTCGAGGCGCTCGCGGATCACCTGCGCCGCCACGCCACCGGGGCCACCATCGGCCGCATCGA
TATCTCGGCCCTGTCCGTGCTCAAGACCTTCGATCCGCCGATCACCGCTTTGCACGGTCAGCCGGTGACGGGTGCGACTC
GCTGGGGCAAGTATCTGGGACTGCAAGCAGGGGATCTGTATCTCGTCACGCACCTGTCCCGTGCGGGGTGGTTGCGCTGG
TCGGACAAGCTGGCGGCGGCACCCCTTAAGCCGGGAAAGGGCCCCATCGCGCTGCGGGTGCACCTCGGAACACCTGGTGA
TGCGCCAGGATTCGATCTCACGGAGGCCGGCACCCAAAAACGGTTGGCCGTGTGGGTGGTGCGAGATCCCGCCGCGGTGC
CGCAGATAGCGTCCCTGGGGCCCGACGCGCTCTCTCTCACTGCCGACGGGCTGGCCGACATATTGGCCGGGACCACTGCG
CGCCTGAAGAACGTGATCACCGACCAACGGGTGATCTCCGGAATCGGCAACGCCTACAGCGACGAGATCCTGCATGTGGC
CAAGCTGTCACCCTTCGCCAGCGGAAAAACGCTGTCCGAAGGGCAACTGACCGCATTGTACGAGGCGATGCAGTCGGTGC
TCACCGATGCGGTAGAGCGTAGCGTCGGACAACAGGCGGCAACTCTTAAGGGGGAGAAGCGATCCGGGTTGCGGGTGCAT
GCCCGCGCCGGGATGCCCTGCCCGGTGTGTGGCGATGTGGTGCGGGAGGTGTCATTCGCCGATAAGTCGTTCCAGTATTG
CCCGACCTGCCAGACCGGTGGCAAGGTGCTAGCCGACCGTCGGCTCTCGCGACTGCTCAAATAA

Upstream 100 bases:

>100_bases
CCGGATCGCGCAGGTTCGTACGGAAGCCCGAGCTGACCACGGCTGGATCATGGACACCTACCTGCTGCGGAGTGTCGGCG
CGTAGGGGCACACTGGGCCC

Downstream 100 bases:

>100_bases
AGTGGCAACGTGACGCGACAGAAGATCCTCATCACCGGGGCGAGCTCCGGCCTGGGTGCCGAGATGGCCCGTCAGTTCGC
TGCGAAGGGACGGGACCTGG

Product: putative formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPELPEVEALADHLRRHATGATIGRIDISALSVLKTFDPPITALHGQPVTGATRWGKYLGLQAGDLYLVTHLSRAGWLRW
SDKLAAAPLKPGKGPIALRVHLGTPGDAPGFDLTEAGTQKRLAVWVVRDPAAVPQIASLGPDALSLTADGLADILAGTTA
RLKNVITDQRVISGIGNAYSDEILHVAKLSPFASGKTLSEGQLTALYEAMQSVLTDAVERSVGQQAATLKGEKRSGLRVH
ARAGMPCPVCGDVVREVSFADKSFQYCPTCQTGGKVLADRRLSRLLK

Sequences:

>Translated_287_residues
MPELPEVEALADHLRRHATGATIGRIDISALSVLKTFDPPITALHGQPVTGATRWGKYLGLQAGDLYLVTHLSRAGWLRW
SDKLAAAPLKPGKGPIALRVHLGTPGDAPGFDLTEAGTQKRLAVWVVRDPAAVPQIASLGPDALSLTADGLADILAGTTA
RLKNVITDQRVISGIGNAYSDEILHVAKLSPFASGKTLSEGQLTALYEAMQSVLTDAVERSVGQQAATLKGEKRSGLRVH
ARAGMPCPVCGDVVREVSFADKSFQYCPTCQTGGKVLADRRLSRLLK
>Mature_286_residues
PELPEVEALADHLRRHATGATIGRIDISALSVLKTFDPPITALHGQPVTGATRWGKYLGLQAGDLYLVTHLSRAGWLRWS
DKLAAAPLKPGKGPIALRVHLGTPGDAPGFDLTEAGTQKRLAVWVVRDPAAVPQIASLGPDALSLTADGLADILAGTTAR
LKNVITDQRVISGIGNAYSDEILHVAKLSPFASGKTLSEGQLTALYEAMQSVLTDAVERSVGQQAATLKGEKRSGLRVHA
RAGMPCPVCGDVVREVSFADKSFQYCPTCQTGGKVLADRRLSRLLK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=286, Percent_Identity=25.8741258741259, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30438; Mature: 30307

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEALADHLRRHATGATIGRIDISALSVLKTFDPPITALHGQPVTGATRWGKYLG
CCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHC
LQAGDLYLVTHLSRAGWLRWSDKLAAAPLKPGKGPIALRVHLGTPGDAPGFDLTEAGTQK
CCCCCEEEEEEHHHHCCEEECCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHCCCCC
RLAVWVVRDPAAVPQIASLGPDALSLTADGLADILAGTTARLKNVITDQRVISGIGNAYS
EEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHH
DEILHVAKLSPFASGKTLSEGQLTALYEAMQSVLTDAVERSVGQQAATLKGEKRSGLRVH
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
ARAGMPCPVCGDVVREVSFADKSFQYCPTCQTGGKVLADRRLSRLLK
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PELPEVEALADHLRRHATGATIGRIDISALSVLKTFDPPITALHGQPVTGATRWGKYLG
CCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHC
LQAGDLYLVTHLSRAGWLRWSDKLAAAPLKPGKGPIALRVHLGTPGDAPGFDLTEAGTQK
CCCCCEEEEEEHHHHCCEEECCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHCCCCC
RLAVWVVRDPAAVPQIASLGPDALSLTADGLADILAGTTARLKNVITDQRVISGIGNAYS
EEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHH
DEILHVAKLSPFASGKTLSEGQLTALYEAMQSVLTDAVERSVGQQAATLKGEKRSGLRVH
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
ARAGMPCPVCGDVVREVSFADKSFQYCPTCQTGGKVLADRRLSRLLK
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA