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The map label for this gene is ldhA [C]

Identifier: 169628094

GI number: 169628094

Start: 1005553

End: 1006737

Strand: Direct

Name: ldhA [C]

Synonym: MAB_0999

Alternate gene names: 169628094

Gene position: 1005553-1006737 (Clockwise)

Preceding gene: 169628093

Following gene: 169628095

Centisome position: 19.84

GC content: 64.05

Gene sequence:

>1185_bases
ATGGCAAAGATCTTGTGTGTGCTCTATCCCGACCCGGTGACGGGGTATCCCCCTGTCTATGCCCGCGATTCACTGCCGGT
GATCGACAGCTACCCGGACGGGCAGTCCCTGCCGACTCCGTCGGCCATCGATTTCACACCCGGTGAGCTGCTGGGTTGCG
TATCGGGTGAACTCGGGCTGCGCCGCTATCTGGAGGCGCACGGCCATGAGTTGGTGGTCACCTCCGATAAGGACGGGCCC
GACTCGGTGTTCGAGAAGGAACTTCCCGACGCCGATGTCGTTATCTCCCAGCCTTTCTGGCCTGCCTACCTCAGTGCCGA
GCGAATTGCCAAGGCGCCGAAGCTCAAGCTGGCATTGACGGCCGGTATCGGCTCTGATCACGTTGATCTGGATGCGGCCA
TCAAGGCCGGAATCACGGTCGCCGAGGTGACCTACTGCAACAGCATCAGTGTCGCCGAGCACGCGGTGATGCAGATCCTG
GCGCTGGTGCGCAACTACCTGCCCGCTCATCAGTGGGTGGTCGACGGCGGCTGGAACATCGCCGACAGCGTCGAGCGTGC
CTATGACCTCGAGGGATTCGATGTCGGCGTTATCGCGGCCGGGCGTATCGGTCAGGCCGTCTTGCGCAGGCTCAAGCCAT
TCGATGTGCGGCTACATTATTTCGACACCCGCCGGCTGCCCGCCGAGGTCGAGCACGAGCTCGGCCTGACGTATCACCCG
GATGTGCAGTCGTTGGTACGTTCGGTCGACATCGTCGACATTCACGCTCCACTGCATCCGCAGACGTACCACCTGTTCGA
CGCGAACCTGATCAACTCGATGCGCCGCGGCTCGTACATCGTGAACACCGCGCGTGCGGAGATCACGGTCCAGGAGGACA
TCGTCAAGGCCCTGGAGTCCGGACAGCTGGCTGGCTACGCGGGTGATGTCTGGTATCCGCAGCCGCCGGCCCCGGATCAC
CCATGGCGCACCATGCCGCACGAGGCGATGACCCCGCACGTTTCCGGAACCACGTTGTCCGCGCAGGCACGGTATGCGGC
CGGCACCCGGGAGATTCTTGAGGACTTCTTCGGGGGACGGTCCATCCGCGACGAGTACCTGATTGTCGAGGGCGGCCAGC
TGGCCGGGACCGGAGCCAAGTCCTATACCGCCGACGGCTCGGCCAGCCCGGGCGCGGGCACTTAG

Upstream 100 bases:

>100_bases
CCGGACACTGAGAATGCGTCGACAAGGCGCATCGGATGTCTGAAAAGTCATCTGTACCAACAGAACCGGCGGCCACAACG
ACCGCCGCAGAGGAGTGGTC

Downstream 100 bases:

>100_bases
GAGTCTGTGCCGGGTCACTACCGGGTGACGGACTCCTGGTGGTGACCCGGCCCGGGACCACTGAATGCCGACAACTCAAT
ATCCACAAACAAATACCGAC

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGELLGCVSGELGLRRYLEAHGHELVVTSDKDGP
DSVFEKELPDADVVISQPFWPAYLSAERIAKAPKLKLALTAGIGSDHVDLDAAIKAGITVAEVTYCNSISVAEHAVMQIL
ALVRNYLPAHQWVVDGGWNIADSVERAYDLEGFDVGVIAAGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHP
DVQSLVRSVDIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKALESGQLAGYAGDVWYPQPPAPDH
PWRTMPHEAMTPHVSGTTLSAQARYAAGTREILEDFFGGRSIRDEYLIVEGGQLAGTGAKSYTADGSASPGAGT

Sequences:

>Translated_394_residues
MAKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGELLGCVSGELGLRRYLEAHGHELVVTSDKDGP
DSVFEKELPDADVVISQPFWPAYLSAERIAKAPKLKLALTAGIGSDHVDLDAAIKAGITVAEVTYCNSISVAEHAVMQIL
ALVRNYLPAHQWVVDGGWNIADSVERAYDLEGFDVGVIAAGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHP
DVQSLVRSVDIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKALESGQLAGYAGDVWYPQPPAPDH
PWRTMPHEAMTPHVSGTTLSAQARYAAGTREILEDFFGGRSIRDEYLIVEGGQLAGTGAKSYTADGSASPGAGT
>Mature_393_residues
AKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGELLGCVSGELGLRRYLEAHGHELVVTSDKDGPD
SVFEKELPDADVVISQPFWPAYLSAERIAKAPKLKLALTAGIGSDHVDLDAAIKAGITVAEVTYCNSISVAEHAVMQILA
LVRNYLPAHQWVVDGGWNIADSVERAYDLEGFDVGVIAAGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHPD
VQSLVRSVDIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKALESGQLAGYAGDVWYPQPPAPDHP
WRTMPHEAMTPHVSGTTLSAQARYAAGTREILEDFFGGRSIRDEYLIVEGGQLAGTGAKSYTADGSASPGAGT

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=29.4701986754967, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI6912396, Length=235, Percent_Identity=32.3404255319149, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4557497, Length=270, Percent_Identity=28.8888888888889, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI61743967, Length=270, Percent_Identity=28.8888888888889, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI145580578, Length=286, Percent_Identity=28.3216783216783, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557499, Length=286, Percent_Identity=28.3216783216783, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=286, Percent_Identity=28.3216783216783, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=33.5106382978723, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789279, Length=247, Percent_Identity=29.5546558704453, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082289, Length=259, Percent_Identity=25.0965250965251, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788660, Length=276, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081824, Length=157, Percent_Identity=27.3885350318471, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=293, Percent_Identity=31.740614334471, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=24.6666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=347, Percent_Identity=46.685878962536, Blast_Score=311, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6324980, Length=211, Percent_Identity=41.2322274881517, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6324979, Length=124, Percent_Identity=57.258064516129, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324055, Length=199, Percent_Identity=35.1758793969849, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=254, Percent_Identity=27.1653543307087, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=235, Percent_Identity=27.6595744680851, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19921140, Length=312, Percent_Identity=28.8461538461538, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=28.0769230769231, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574284, Length=243, Percent_Identity=28.8065843621399, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24585514, Length=243, Percent_Identity=28.8065843621399, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574282, Length=243, Percent_Identity=28.8065843621399, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551003, Length=243, Percent_Identity=28.8065843621399, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552429, Length=243, Percent_Identity=28.8065843621399, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=28.0442804428044, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=28.0442804428044, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=28.0442804428044, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=28.0442804428044, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=28.0442804428044, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=27.0588235294118, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585516, Length=320, Percent_Identity=25.625, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 42763; Mature: 42631

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGELLGCVSGELGL
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHH
RRYLEAHGHELVVTSDKDGPDSVFEKELPDADVVISQPFWPAYLSAERIAKAPKLKLALT
HHHHHHCCCEEEEECCCCCCHHHHHHHCCCCCEEEECCCCHHHHCHHHHHCCCCEEEEEE
AGIGSDHVDLDAAIKAGITVAEVTYCNSISVAEHAVMQILALVRNYLPAHQWVVDGGWNI
ECCCCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCH
ADSVERAYDLEGFDVGVIAAGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHP
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCEECC
DVQSLVRSVDIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKALES
CHHHHHHHCCEEEEECCCCCCEEEEECHHHHHHHHCCCEEEEECCEEEEEHHHHHHHHHC
GQLAGYAGDVWYPQPPAPDHPWRTMPHEAMTPHVSGTTLSAQARYAAGTREILEDFFGGR
CCCCEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCHHHHCCHHHHHHHHHCCC
SIRDEYLIVEGGQLAGTGAKSYTADGSASPGAGT
CCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGELLGCVSGELGL
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHH
RRYLEAHGHELVVTSDKDGPDSVFEKELPDADVVISQPFWPAYLSAERIAKAPKLKLALT
HHHHHHCCCEEEEECCCCCCHHHHHHHCCCCCEEEECCCCHHHHCHHHHHCCCCEEEEEE
AGIGSDHVDLDAAIKAGITVAEVTYCNSISVAEHAVMQILALVRNYLPAHQWVVDGGWNI
ECCCCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCH
ADSVERAYDLEGFDVGVIAAGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHP
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCEECC
DVQSLVRSVDIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKALES
CHHHHHHHCCEEEEECCCCCCEEEEECHHHHHHHHCCCEEEEECCEEEEEHHHHHHHHHC
GQLAGYAGDVWYPQPPAPDHPWRTMPHEAMTPHVSGTTLSAQARYAAGTREILEDFFGGR
CCCCEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCHHHHCCHHHHHHHHHCCC
SIRDEYLIVEGGQLAGTGAKSYTADGSASPGAGT
CCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]