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The map label for this gene is cynR [H]

Identifier: 169628093

GI number: 169628093

Start: 1004506

End: 1005396

Strand: Direct

Name: cynR [H]

Synonym: MAB_0998

Alternate gene names: 169628093

Gene position: 1004506-1005396 (Clockwise)

Preceding gene: 169628091

Following gene: 169628094

Centisome position: 19.82

GC content: 69.25

Gene sequence:

>891_bases
ATGCAGTTCCGGCAGCTTGAATACTTCGTGGCGTTGGCGCGCGAGCGACACTTCGCGCGCGCGGCATCGGCGTGCTACGT
CTCCCAGCCCGCGCTTTCGGAGGCAATCCGCAAGCTCGAACACGAACTGGGTGTTCCGCTGGTGCTGCGCGGCTCCAACT
TCGAGGGGCTGACCCCGGAGGGGGATCGCCTGGTCCTCTGGGCGAGAAGGATCCTCGCGGACCGTGACGCGCTGGAGCAT
GAAGTGACCGCACTACGCAGCGGGCTTACCGGTGAATTGCGGCTTGGCGTGGTGCCCGGTGCGGCCACCCGGGTCGCGCT
CATGGCCGACGCGTTGTGCGCCGAGCATCCACTGGTGCGCGTGCGCATCGAGTCCAGCCTGCGGTCGGTGGAGATCCTGG
ACCGCATCCGCCGGTTCGAACTCGACGCGGGGGTGGTTTACGACGACGGTCTGCAGACCGATGGGCTCGAGCTGACCCGT
CTGTACGAGGAACGTTATGTGTTGGTGGCGGGCGACGGGTTGTTGCGGGATGCCCACGACCCGATCGACTGGTCAGAGGC
TTTGAGCTTGCCGATGTGCCTGTTGCACAAAGGAATGCGCGACCGTGATCGGATAGACGAGGCGGCCGCCGAGCACGGGC
TGGCGGTGTCACCCCGGCTGGAGGCTGATTCGGTGGCCACGCTGCTCGCGCTGGTGGGCACCGGACGCTGGGCGGCGATC
GTCGCCCGGACCTGGTTCGCCACTGCCGCGCCGCCCGCGGGCACGCGCACCGTCGAGCTGCAGGCGCCGACGCTCGGCTC
TCCAGTGGCCTTGGTCCGCGCCGCGGGTGATCCCGCCTCGCTGCTTGCCCGCGCGCTGGCGCAGGTGGTGGCCCCGCCCG
ACCAGCCCTGA

Upstream 100 bases:

>100_bases
CGGTAATGCTCTCCAGTCTGTGTGGGCCGGAGCATGCCTGTCCAAGACGCGTTGCCGCTGACCTGATAGGCAGCGCCGAT
CGCTGGTGGTAGAACGAATT

Downstream 100 bases:

>100_bases
TCGGCCGCGCCTATCGGGCGGTCGGAACTTGGTCTTGGACACCTGTGCGCCTCGCGCCGGACACTGAGAATGCGTCGACA
AGGCGCATCGGATGTCTGAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MQFRQLEYFVALARERHFARAASACYVSQPALSEAIRKLEHELGVPLVLRGSNFEGLTPEGDRLVLWARRILADRDALEH
EVTALRSGLTGELRLGVVPGAATRVALMADALCAEHPLVRVRIESSLRSVEILDRIRRFELDAGVVYDDGLQTDGLELTR
LYEERYVLVAGDGLLRDAHDPIDWSEALSLPMCLLHKGMRDRDRIDEAAAEHGLAVSPRLEADSVATLLALVGTGRWAAI
VARTWFATAAPPAGTRTVELQAPTLGSPVALVRAAGDPASLLARALAQVVAPPDQP

Sequences:

>Translated_296_residues
MQFRQLEYFVALARERHFARAASACYVSQPALSEAIRKLEHELGVPLVLRGSNFEGLTPEGDRLVLWARRILADRDALEH
EVTALRSGLTGELRLGVVPGAATRVALMADALCAEHPLVRVRIESSLRSVEILDRIRRFELDAGVVYDDGLQTDGLELTR
LYEERYVLVAGDGLLRDAHDPIDWSEALSLPMCLLHKGMRDRDRIDEAAAEHGLAVSPRLEADSVATLLALVGTGRWAAI
VARTWFATAAPPAGTRTVELQAPTLGSPVALVRAAGDPASLLARALAQVVAPPDQP
>Mature_296_residues
MQFRQLEYFVALARERHFARAASACYVSQPALSEAIRKLEHELGVPLVLRGSNFEGLTPEGDRLVLWARRILADRDALEH
EVTALRSGLTGELRLGVVPGAATRVALMADALCAEHPLVRVRIESSLRSVEILDRIRRFELDAGVVYDDGLQTDGLELTR
LYEERYVLVAGDGLLRDAHDPIDWSEALSLPMCLLHKGMRDRDRIDEAAAEHGLAVSPRLEADSVATLLALVGTGRWAAI
VARTWFATAAPPAGTRTVELQAPTLGSPVALVRAAGDPASLLARALAQVVAPPDQP

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=294, Percent_Identity=29.5918367346939, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790399, Length=99, Percent_Identity=46.4646464646465, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=27.7551020408163, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367136, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790208, Length=126, Percent_Identity=34.9206349206349, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788887, Length=183, Percent_Identity=36.6120218579235, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787879, Length=101, Percent_Identity=38.6138613861386, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=210, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=291, Percent_Identity=25.085910652921, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32182; Mature: 32182

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRQLEYFVALARERHFARAASACYVSQPALSEAIRKLEHELGVPLVLRGSNFEGLTPE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GDRLVLWARRILADRDALEHEVTALRSGLTGELRLGVVPGAATRVALMADALCAEHPLVR
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEE
VRIESSLRSVEILDRIRRFELDAGVVYDDGLQTDGLELTRLYEERYVLVAGDGLLRDAHD
EEEHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHCEEEEECCCCCCCCCC
PIDWSEALSLPMCLLHKGMRDRDRIDEAAAEHGLAVSPRLEADSVATLLALVGTGRWAAI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCHHHHH
VARTWFATAAPPAGTRTVELQAPTLGSPVALVRAAGDPASLLARALAQVVAPPDQP
HHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFRQLEYFVALARERHFARAASACYVSQPALSEAIRKLEHELGVPLVLRGSNFEGLTPE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GDRLVLWARRILADRDALEHEVTALRSGLTGELRLGVVPGAATRVALMADALCAEHPLVR
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEE
VRIESSLRSVEILDRIRRFELDAGVVYDDGLQTDGLELTRLYEERYVLVAGDGLLRDAHD
EEEHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHCEEEEECCCCCCCCCC
PIDWSEALSLPMCLLHKGMRDRDRIDEAAAEHGLAVSPRLEADSVATLLALVGTGRWAAI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCHHHHH
VARTWFATAAPPAGTRTVELQAPTLGSPVALVRAAGDPASLLARALAQVVAPPDQP
HHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]