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The map label for this gene is prrA [H]

Identifier: 169628053

GI number: 169628053

Start: 964126

End: 964827

Strand: Reverse

Name: prrA [H]

Synonym: MAB_0956c

Alternate gene names: 169628053

Gene position: 964827-964126 (Counterclockwise)

Preceding gene: 169628055

Following gene: 169628052

Centisome position: 19.04

GC content: 67.66

Gene sequence:

>702_bases
ATGGTTGATGGGCAGGGCTCCCCGCGCGTACTGGTGGTGGACGACGACGCCGACGTGCTCGCCTCGCTGGAACGCGGCCT
GCGCCTCTCCGGATTCGAGGTGAATACCGCCAGCGACGGCGCCGAGGCGCTGCGCTGCGCCACCGAACACCGTCCGGACG
CGATAGTGCTCGATATCAACATGCCGGTGCTGGACGGTGTCAGTGTGGTGACCGCGTTGCGCGCGATGGACAACGACGTA
CCGGTCTGTGTGCTCTCCGCACGCACCTCGGTCGACGATCGGGTCGCCGGCCTGGAGGCCGGTGCCGACGACTATCTGAC
CAAGCCGTTCGTGCTCGCCGAGTTGGTGGCCCGCGTCAAAGCGCTGCTGCGCCGCCGCGGCGCAGTAGCCACGTCGTCGA
CGGAAACCATCACCGTGGGGCCCCTGGAGGTGGAGATTCCGGGCCGGCGCGCCCGCATCAACGGTGTCGAGGTCGATCTC
ACCAAACGCGAGTTCGATCTGCTGGCGGTACTGGCCGAACACAAGACCGCGGTGCTGTCACGCGCCCAGCTGCTGGAGCT
GGTGTGGGGCTACGACTTTGCCGCCGACACCAACGTCGTCGACGTGTTCATCGGTTACCTGCGCCGCAAGCTGGAGGCCG
GCGGTGCACCCCGGCTGTTGCACACCGTGCGCGGTGTCGGGTTCGTGCTGCGTTCGCAGTAG

Upstream 100 bases:

>100_bases
ACGCCGGATTATCAGCTTTCATGATACTGGCGACGCCCGGCACAGCACCGGCGACGATAGTTCGACCGTTTTACCCATCT
CATCGGGCAAGATGGCAGGC

Downstream 100 bases:

>100_bases
CGACGGATGAGCACCTCGCACGAGAACCCGCCAGTCATGGGCCGCCCCAGCAAGCACCGCAGTCAACGGATCACCGATCT
GTCCTACCGGTTATTGGAGA

Product: transcriptional regulatory protein PrrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MVDGQGSPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEALRCATEHRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVARVKALLRRRGAVATSSTETITVGPLEVEIPGRRARINGVEVDL
TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ

Sequences:

>Translated_233_residues
MVDGQGSPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEALRCATEHRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVARVKALLRRRGAVATSSTETITVGPLEVEIPGRRARINGVEVDL
TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ
>Mature_233_residues
MVDGQGSPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEALRCATEHRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVARVKALLRRRGAVATSSTETITVGPLEVEIPGRRARINGVEVDL
TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=39.1891891891892, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=39.1891891891892, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.4545454545455, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=34.6846846846847, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=35.4978354978355, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=38.1818181818182, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=34.0807174887892, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=39.3939393939394, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.1681415929204, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.5676855895196, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=31.858407079646, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=36.9369369369369, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=26.8398268398268, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=34.2105263157895, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=31.858407079646, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1788905, Length=101, Percent_Identity=34.6534653465347, Blast_Score=61, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=118, Percent_Identity=32.2033898305085, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25070; Mature: 25070

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDGQGSPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEALRCATEHRPDAIVLDIN
CCCCCCCCEEEEEECCHHHHHHHHCCCEECCEEECCCCCHHHHHHHHHCCCCCEEEEEEC
MPVLDGVSVVTALRAMDNDVPVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVARVK
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHHH
ALLRRRGAVATSSTETITVGPLEVEIPGRRARINGVEVDLTKREFDLLAVLAEHKTAVLS
HHHHHCCCCEECCCCEEEECCEEEEECCCEEEECCEEEEECHHHHHHHHHHHHHHHHHHH
RAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MVDGQGSPRVLVVDDDADVLASLERGLRLSGFEVNTASDGAEALRCATEHRPDAIVLDIN
CCCCCCCCEEEEEECCHHHHHHHHCCCEECCEEECCCCCHHHHHHHHHCCCCCEEEEEEC
MPVLDGVSVVTALRAMDNDVPVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVARVK
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHHH
ALLRRRGAVATSSTETITVGPLEVEIPGRRARINGVEVDLTKREFDLLAVLAEHKTAVLS
HHHHHCCCCEECCCCEEEECCEEEEECCCEEEECCEEEEECHHHHHHHHHHHHHHHHHHH
RAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRSQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]