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The map label for this gene is frlR [H]

Identifier: 169628050

GI number: 169628050

Start: 961516

End: 962337

Strand: Direct

Name: frlR [H]

Synonym: MAB_0953

Alternate gene names: 169628050

Gene position: 961516-962337 (Clockwise)

Preceding gene: 169628049

Following gene: 169628051

Centisome position: 18.98

GC content: 66.3

Gene sequence:

>822_bases
ATGGAGGAGTCGGAGGGCGGCCCGGTAGCCGAAGATGTGCGGCGTCGAATCCTGTCGATGCTCGCACAGGGCACGTTGCA
TCCGGGTTCACGGCTGGGGTCCGAGCGCGAGATGGCCGAGCGCTTCGCGGTGTCGCGCGCGACGGTACGCAGTGCGTTGG
TGCCGTTGAGCCGGGCCGGCATTCTGGAGCGTCAAACCGGCCGTGGCGGGGGCACCTTCGTACGCGCCGATGTGGTGCAG
CGCAACGTGGCCGAGCTGGTGGGTCTGCCCACCAGGCTGCACATCGGTGGCCACACGAGCGATACCCGGGTGCTGGGCAC
CTCCCGGCGGCCCGCCACTGCGGCCGAACGAGCGGCCCTCGAAATTGCCGAAGGCGCAGAAGTTTTCGATGTGCGGCGGC
TTCGATATGCCGATGGAGTGCCGCTATCGGTCGACACCGCGTATTTTCCCGCCGAGTTGGTGCCGGACTTGCTCGAACAG
CCGTTGGGGGGATCGCTGTACGAGCTGTGCCAGGTGCGTTATGGCTTACAAGCGGACTCATCGACGGAAACAATCGAAGT
GGTCAGCGCCAACCCGCGTGAGGCCGAATGGCTTGACGTGCCGCACCGCAGGCCCCTGTTGGCTATCACCCGGGTGACCC
GCAATACCGACGGCCGGCCCTTCGAATTCAGTTATGACCTGTTCCGTGCGGACCGAGTGCGCCTGACGGCCACCATGACA
TCGGCCGTCGCGCAGGAAAGTCGTGGTGTGGACGGCAAGGTGGAACGGGTGGTGAGCAGACTGGCGGCCCACCGGCGGCC
GGACGATACGCTGCTGGCATGA

Upstream 100 bases:

>100_bases
TACATCACCGGACAGGCCATCGTGGTTGACGGCGGGCAAGTACTGCCCGAATCGCCGGACGCGGTTAACCCCTAGGTGCG
TTTGCGGCGATACTGAGCAG

Downstream 100 bases:

>100_bases
CGAAACCCGAGATCGACTTTCAGCCAGGTCCGCCGCCCACCGAACTGGTCATCAAGGACATCACCGTCGGTGACGGTGCG
GAGGCCACCCCCGGATCGGT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEESEGGPVAEDVRRRILSMLAQGTLHPGSRLGSEREMAERFAVSRATVRSALVPLSRAGILERQTGRGGGTFVRADVVQ
RNVAELVGLPTRLHIGGHTSDTRVLGTSRRPATAAERAALEIAEGAEVFDVRRLRYADGVPLSVDTAYFPAELVPDLLEQ
PLGGSLYELCQVRYGLQADSSTETIEVVSANPREAEWLDVPHRRPLLAITRVTRNTDGRPFEFSYDLFRADRVRLTATMT
SAVAQESRGVDGKVERVVSRLAAHRRPDDTLLA

Sequences:

>Translated_273_residues
MEESEGGPVAEDVRRRILSMLAQGTLHPGSRLGSEREMAERFAVSRATVRSALVPLSRAGILERQTGRGGGTFVRADVVQ
RNVAELVGLPTRLHIGGHTSDTRVLGTSRRPATAAERAALEIAEGAEVFDVRRLRYADGVPLSVDTAYFPAELVPDLLEQ
PLGGSLYELCQVRYGLQADSSTETIEVVSANPREAEWLDVPHRRPLLAITRVTRNTDGRPFEFSYDLFRADRVRLTATMT
SAVAQESRGVDGKVERVVSRLAAHRRPDDTLLA
>Mature_273_residues
MEESEGGPVAEDVRRRILSMLAQGTLHPGSRLGSEREMAERFAVSRATVRSALVPLSRAGILERQTGRGGGTFVRADVVQ
RNVAELVGLPTRLHIGGHTSDTRVLGTSRRPATAAERAALEIAEGAEVFDVRRLRYADGVPLSVDTAYFPAELVPDLLEQ
PLGGSLYELCQVRYGLQADSSTETIEVVSANPREAEWLDVPHRRPLLAITRVTRNTDGRPFEFSYDLFRADRVRLTATMT
SAVAQESRGVDGKVERVVSRLAAHRRPDDTLLA

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=225, Percent_Identity=31.1111111111111, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786950, Length=236, Percent_Identity=30.0847457627119, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790118, Length=221, Percent_Identity=33.4841628959276, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788418, Length=213, Percent_Identity=29.5774647887324, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790540, Length=209, Percent_Identity=30.622009569378, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 29923; Mature: 29923

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESEGGPVAEDVRRRILSMLAQGTLHPGSRLGSEREMAERFAVSRATVRSALVPLSRAG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
ILERQTGRGGGTFVRADVVQRNVAELVGLPTRLHIGGHTSDTRVLGTSRRPATAAERAAL
CHHCCCCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHH
EIAEGAEVFDVRRLRYADGVPLSVDTAYFPAELVPDLLEQPLGGSLYELCQVRYGLQADS
HHHCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
STETIEVVSANPREAEWLDVPHRRPLLAITRVTRNTDGRPFEFSYDLFRADRVRLTATMT
CCCEEEEEECCCCCCHHCCCCCCCCHHEEEHHHCCCCCCCEEEEHHHHHCCCEEEHHHHH
SAVAQESRGVDGKVERVVSRLAAHRRPDDTLLA
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEESEGGPVAEDVRRRILSMLAQGTLHPGSRLGSEREMAERFAVSRATVRSALVPLSRAG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
ILERQTGRGGGTFVRADVVQRNVAELVGLPTRLHIGGHTSDTRVLGTSRRPATAAERAAL
CHHCCCCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHH
EIAEGAEVFDVRRLRYADGVPLSVDTAYFPAELVPDLLEQPLGGSLYELCQVRYGLQADS
HHHCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
STETIEVVSANPREAEWLDVPHRRPLLAITRVTRNTDGRPFEFSYDLFRADRVRLTATMT
CCCEEEEEECCCCCCHHCCCCCCCCHHEEEHHHCCCCCCCEEEEHHHHHCCCEEEHHHHH
SAVAQESRGVDGKVERVVSRLAAHRRPDDTLLA
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]