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The map label for this gene is gabT [C]

Identifier: 169628046

GI number: 169628046

Start: 956544

End: 957863

Strand: Reverse

Name: gabT [C]

Synonym: MAB_0949c

Alternate gene names: 169628046

Gene position: 957863-956544 (Counterclockwise)

Preceding gene: 169628047

Following gene: 169628045

Centisome position: 18.9

GC content: 64.62

Gene sequence:

>1320_bases
ATGAGCTTTTCCAACATCATGGATTCGAATAGCTACGCCGGAGTGCACGACGACCCGGCCACCGAATCTCTGATCACCGC
CCGGGAACGGGTGCTCGGCCCGTCCTATCGGCTGTTCTACGAGCGGCCGGTGCACCTGGTGCGCGGCCAGGGCAGTCACC
TCTTCGACAACGAGGGCAACCGCTACCTGGATGCCTACAACAACGTGGCAAGCGTGGGCCATTGCCACCCACACGTCGTC
GGCGCGGTCACCCGGCAGCTGTCCGCCCTCAACACCCACACGCGGTATCTCCACGAGGGCATCGTCGATTACTCGGAACG
TCTGCTTGCCACCATGCCCACCCCCATCGACCAGGTGATGTATGCGTGCACCGGCTCCGAGGCCAATGACCTGGCACTAC
GGGTGGCTCAGAGGTACACAGGACACAAGGGAATCGTCGTGACCAGCGACGCCTACCACGGCAATACCGCGGCGGTCACC
GCGATCTCGCCCTCTCTCGGGGGAAACTCGTTGGGAGCGCACGTTCGTACCGTCGCGCCGCCCGACAGCTATCGGACCCC
ACCGGGCGAGCTGGCCGAGCGCTTCGCCGCCGACGTATCGCATGCCATCGATGAACTATGTGCCGCGGGATACGGGTTCA
GCTGCCTGGTGGTCGACACCATTTTCTCGTCGGACGGGATCTATCCGGATGCCTCGGTGTTGGAACCGGCGGCGGAGGTG
GTGCGCGGCGCGGGCGGTGTGCTGATCGCCGACGAAGTGCAGCCCGGATTTGGCCGCACCGGCGAAACCTGGTGGGGGTT
CATCCGCCATGGCGTGGTGCCCGACCTGGTCACCATGGGAAAGCCTATGGCCAATGGCATTCCGGTTTCGGCGCTGGCAG
CCACCTCCGAAGTCCTCGCACCGTTCGCGCAGGATGTCCCGTATTTCAACACCTTCGGGGGAAATCCGGTATCGATGGCC
GCGGCCGCGGCCGTCATGGACGTGATCGAGGATGAAAAGCTACAGCTGCATGCCGCGGAGGTCGGCGCGATGCTGCGCAC
CGAACTACGCTCCCTGGCCTCGACCCACGTCCGGCTCGGCGACGTCCGGGGTACCGGCCTGTACACGGGAGTGGAGGTGG
TCGACGACCCCGCCGCCCGCACTCCCGATCGCGCCGGAGCGCTGCACATCGTGAATGAGCTGCGGAACCGACGGGTTTTG
ATATCGGTCTGCGGACAGGATGGCAATGTGCTGAAAATCCGTCCCCCGCTGGTGTTCTCGCGATCGGACGTGGACTGGTT
CTGCACCGAACTCGACGACGTACTGAAAAGCACCGGCTGA

Upstream 100 bases:

>100_bases
CCGGAATCGGCGGTATCGCCTTGGCTCTCACCCTCAAGTACACCGCACCACACCGTTATGACGACCTTGGCAGAACCGTG
CTCGAGGAGGCACACGAACG

Downstream 100 bases:

>100_bases
TCACCCGAAGGCCGTACAGTCGTTTCATGGGCCTTTCAGAATCCGATCGATACGACACGGTCATCGTCGGCGGTGGCCAC
AACGCCCTGACCGCGGCCGC

Product: aminotransferase

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSFSNIMDSNSYAGVHDDPATESLITARERVLGPSYRLFYERPVHLVRGQGSHLFDNEGNRYLDAYNNVASVGHCHPHVV
GAVTRQLSALNTHTRYLHEGIVDYSERLLATMPTPIDQVMYACTGSEANDLALRVAQRYTGHKGIVVTSDAYHGNTAAVT
AISPSLGGNSLGAHVRTVAPPDSYRTPPGELAERFAADVSHAIDELCAAGYGFSCLVVDTIFSSDGIYPDASVLEPAAEV
VRGAGGVLIADEVQPGFGRTGETWWGFIRHGVVPDLVTMGKPMANGIPVSALAATSEVLAPFAQDVPYFNTFGGNPVSMA
AAAAVMDVIEDEKLQLHAAEVGAMLRTELRSLASTHVRLGDVRGTGLYTGVEVVDDPAARTPDRAGALHIVNELRNRRVL
ISVCGQDGNVLKIRPPLVFSRSDVDWFCTELDDVLKSTG

Sequences:

>Translated_439_residues
MSFSNIMDSNSYAGVHDDPATESLITARERVLGPSYRLFYERPVHLVRGQGSHLFDNEGNRYLDAYNNVASVGHCHPHVV
GAVTRQLSALNTHTRYLHEGIVDYSERLLATMPTPIDQVMYACTGSEANDLALRVAQRYTGHKGIVVTSDAYHGNTAAVT
AISPSLGGNSLGAHVRTVAPPDSYRTPPGELAERFAADVSHAIDELCAAGYGFSCLVVDTIFSSDGIYPDASVLEPAAEV
VRGAGGVLIADEVQPGFGRTGETWWGFIRHGVVPDLVTMGKPMANGIPVSALAATSEVLAPFAQDVPYFNTFGGNPVSMA
AAAAVMDVIEDEKLQLHAAEVGAMLRTELRSLASTHVRLGDVRGTGLYTGVEVVDDPAARTPDRAGALHIVNELRNRRVL
ISVCGQDGNVLKIRPPLVFSRSDVDWFCTELDDVLKSTG
>Mature_438_residues
SFSNIMDSNSYAGVHDDPATESLITARERVLGPSYRLFYERPVHLVRGQGSHLFDNEGNRYLDAYNNVASVGHCHPHVVG
AVTRQLSALNTHTRYLHEGIVDYSERLLATMPTPIDQVMYACTGSEANDLALRVAQRYTGHKGIVVTSDAYHGNTAAVTA
ISPSLGGNSLGAHVRTVAPPDSYRTPPGELAERFAADVSHAIDELCAAGYGFSCLVVDTIFSSDGIYPDASVLEPAAEVV
RGAGGVLIADEVQPGFGRTGETWWGFIRHGVVPDLVTMGKPMANGIPVSALAATSEVLAPFAQDVPYFNTFGGNPVSMAA
AAAVMDVIEDEKLQLHAAEVGAMLRTELRSLASTHVRLGDVRGTGLYTGVEVVDDPAARTPDRAGALHIVNELRNRRVLI
SVCGQDGNVLKIRPPLVFSRSDVDWFCTELDDVLKSTG

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=42.6190476190476, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=41.1904761904762, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=43.2941176470588, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI226442709, Length=375, Percent_Identity=42.4, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=32.7058823529412, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4557809, Length=447, Percent_Identity=26.6219239373602, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI284507298, Length=199, Percent_Identity=30.6532663316583, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789016, Length=393, Percent_Identity=30.7888040712468, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=30.3030303030303, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=29.5285359801489, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI145693181, Length=388, Percent_Identity=27.5773195876289, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789759, Length=396, Percent_Identity=27.020202020202, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786991, Length=379, Percent_Identity=25.8575197889182, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786349, Length=305, Percent_Identity=25.5737704918033, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=450, Percent_Identity=35.5555555555556, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI32564660, Length=440, Percent_Identity=32.9545454545455, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=26.7942583732057, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71992985, Length=142, Percent_Identity=36.6197183098592, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=200, Percent_Identity=26.5, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17541228, Length=439, Percent_Identity=24.1457858769932, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=28.5359801488834, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=369, Percent_Identity=24.1192411924119, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=40.7925407925408, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI161085790, Length=468, Percent_Identity=35.4700854700855, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI28574759, Length=458, Percent_Identity=35.589519650655, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21357415, Length=431, Percent_Identity=27.8422273781903, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 46998; Mature: 46867

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSNIMDSNSYAGVHDDPATESLITARERVLGPSYRLFYERPVHLVRGQGSHLFDNEGN
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCEEECCCCC
RYLDAYNNVASVGHCHPHVVGAVTRQLSALNTHTRYLHEGIVDYSERLLATMPTPIDQVM
EEHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
YACTGSEANDLALRVAQRYTGHKGIVVTSDAYHGNTAAVTAISPSLGGNSLGAHVRTVAP
HHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEEECC
PDSYRTPPGELAERFAADVSHAIDELCAAGYGFSCLVVDTIFSSDGIYPDASVLEPAAEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHH
VRGAGGVLIADEVQPGFGRTGETWWGFIRHGVVPDLVTMGKPMANGIPVSALAATSEVLA
HHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
PFAQDVPYFNTFGGNPVSMAAAAAVMDVIEDEKLQLHAAEVGAMLRTELRSLASTHVRLG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHEEE
DVRGTGLYTGVEVVDDPAARTPDRAGALHIVNELRNRRVLISVCGQDGNVLKIRPPLVFS
CCCCCCEEECCEEECCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCEEEECCCEEEE
RSDVDWFCTELDDVLKSTG
CCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFSNIMDSNSYAGVHDDPATESLITARERVLGPSYRLFYERPVHLVRGQGSHLFDNEGN
CCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCEEECCCCC
RYLDAYNNVASVGHCHPHVVGAVTRQLSALNTHTRYLHEGIVDYSERLLATMPTPIDQVM
EEHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
YACTGSEANDLALRVAQRYTGHKGIVVTSDAYHGNTAAVTAISPSLGGNSLGAHVRTVAP
HHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEEECC
PDSYRTPPGELAERFAADVSHAIDELCAAGYGFSCLVVDTIFSSDGIYPDASVLEPAAEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHH
VRGAGGVLIADEVQPGFGRTGETWWGFIRHGVVPDLVTMGKPMANGIPVSALAATSEVLA
HHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
PFAQDVPYFNTFGGNPVSMAAAAAVMDVIEDEKLQLHAAEVGAMLRTELRSLASTHVRLG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHEEE
DVRGTGLYTGVEVVDDPAARTPDRAGALHIVNELRNRRVLISVCGQDGNVLKIRPPLVFS
CCCCCCEEECCEEECCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCEEEECCCEEEE
RSDVDWFCTELDDVLKSTG
CCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA