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The map label for this gene is fgd1 [H]

Identifier: 169628044

GI number: 169628044

Start: 954059

End: 954994

Strand: Reverse

Name: fgd1 [H]

Synonym: MAB_0947c

Alternate gene names: 169628044

Gene position: 954994-954059 (Counterclockwise)

Preceding gene: 169628045

Following gene: 169628035

Centisome position: 18.85

GC content: 66.45

Gene sequence:

>936_bases
ATGACACGTTTCGGCTATACCTTGATGACAGAGCAGAGCGGACCAAAAGACCTTGTCCGTTATGCCGTCGCCGCCGAAAA
GGCGGGATTCGACTTCGAAGTGTCCAGCGACCACTACTCACCGTGGCTCAGTTCGCAAGGACATGCTCCCTACGCCTGGT
CGGTGCTCGGGGCGGTCGCCCAGGCCACGGAACGAGTGGATCTGGCGACCTACGTGACCTGCCCGACCATGCGTTATCAC
CCGGCCGTCGTCGCGCAGAAGGCGGCCACCATGCAGATCCTTGCCGACGGACGGTTCACCTTGGGCCTGGGCAGCGGGGA
GAACCTCAACGAGCACGTCGTCGGGCGCGGATGGCCCACCGTGGGACGGCGCCAGGCGATGCTCAGGGAAGCCATCCAGA
TCATTCGCGACCTGCTGTGCGGGGAACACGTGGACGGCAAGGGTGATTACTTCGAGGTCGACTCGGCCCGGCTGTGGGAC
CTGCCCGATGTCCCGGTGCCCATCGGCGTCGCGGTGTCCAGCGGTGACACGGCGGCACGCTTCGCGCCGACGGCCGACCA
TATGATCGCGGTCGCGCCCGAATCGGACATTGTGGACGCCTGGCGACAGGCCCGCAGGTCGGCGGCCGCACCCGAGGAGA
GCCGCGTGATCGGTCAACTGCCGATCTGCTGGGATACCGACCGGGAGGCGGCGATCAAGCGCGCCCACGACGAGTTTCGC
TGGTTCGCCGGGGGCTGGCCCGTGAACGCCGACCTTCCGACCCCTGCCGGGTTCGCCGCGGCAACGAAATTCGTCCGACC
GGAGGATGTCGCCGGCAATATCCCCTGCGGATCGGATTCGGCACCATCATCGAGAACGCGCGCGCCTACGCCGACGCCGG
GTTTACCGATATCGCGCTGGTGCAGGTGGGAGGCGACAGCCAGGACAGCTTCCTGA

Upstream 100 bases:

>100_bases
GGTTGGGCGGATATCACGCCGCGAGGGCAGTGCTGGAGACGCACTGAGCCGCACTCCACAGCGAGGTTTCACACCGGCTG
GTAGCGGGTACGCGCGCGGT

Downstream 100 bases:

>100_bases
CCGAGGCGGCCGAACCGCTGCTCGCGGAATTGCGCGCCTCCATCTAGCAAGGCCTCATCGGTGTGACGCGGTCGCTTTCT
CCAGAAGCGCACGCAGAGAA

Product: putative luciferase

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTRFGYTLMTEQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVAQATERVDLATYVTCPTMRYH
PAVVAQKAATMQILADGRFTLGLGSGENLNEHVVGRGWPTVGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARLWD
LPDVPVPIGVAVSSGDTAARFAPTADHMIAVAPESDIVDAWRQARRSAAAPEESRVIGQLPICWDTDREAAIKRAHDEFR
WFAGGWPVNADLPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLPISRWCRWEATARTAS

Sequences:

>Translated_311_residues
MTRFGYTLMTEQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVAQATERVDLATYVTCPTMRYH
PAVVAQKAATMQILADGRFTLGLGSGENLNEHVVGRGWPTVGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARLWD
LPDVPVPIGVAVSSGDTAARFAPTADHMIAVAPESDIVDAWRQARRSAAAPEESRVIGQLPICWDTDREAAIKRAHDEFR
WFAGGWPVNADLPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLPISRWCRWEATARTAS
>Mature_310_residues
TRFGYTLMTEQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVAQATERVDLATYVTCPTMRYHP
AVVAQKAATMQILADGRFTLGLGSGENLNEHVVGRGWPTVGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARLWDL
PDVPVPIGVAVSSGDTAARFAPTADHMIAVAPESDIVDAWRQARRSAAAPEESRVIGQLPICWDTDREAAIKRAHDEFRW
FAGGWPVNADLPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLPISRWCRWEATARTAS

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787247, Length=224, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 33749; Mature: 33618

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFGYTLMTEQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVA
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHH
QATERVDLATYVTCPTMRYHPAVVAQKAATMQILADGRFTLGLGSGENLNEHVVGRGWPT
HHHHHHCEEEEEECCCCCCCHHHHHHHHHEEEEEECCCEEEEECCCCCCCCCCCCCCCCC
VGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARLWDLPDVPVPIGVAVSSGDTAAR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECCCCCCCCCEEEEEECCCCHHE
FAPTADHMIAVAPESDIVDAWRQARRSAAAPEESRVIGQLPICWDTDREAAIKRAHDEFR
ECCCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHCEEECCCEEECCCHHHHHHHHHHHHE
WFAGGWPVNADLPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLPISRW
EEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
CRWEATARTAS
HCCCCCCCCCC
>Mature Secondary Structure 
TRFGYTLMTEQSGPKDLVRYAVAAEKAGFDFEVSSDHYSPWLSSQGHAPYAWSVLGAVA
CCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHH
QATERVDLATYVTCPTMRYHPAVVAQKAATMQILADGRFTLGLGSGENLNEHVVGRGWPT
HHHHHHCEEEEEECCCCCCCHHHHHHHHHEEEEEECCCEEEEECCCCCCCCCCCCCCCCC
VGRRQAMLREAIQIIRDLLCGEHVDGKGDYFEVDSARLWDLPDVPVPIGVAVSSGDTAAR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECCCCCCCCCEEEEEECCCCHHE
FAPTADHMIAVAPESDIVDAWRQARRSAAAPEESRVIGQLPICWDTDREAAIKRAHDEFR
ECCCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHCEEECCCEEECCCHHHHHHHHHHHHE
WFAGGWPVNADLPTPAGFAAATKFVRPEDVAGNIPCGSDSAPSSRTRAPTPTPGLPISRW
EEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
CRWEATARTAS
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]