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The map label for this gene is gltA [H]

Identifier: 169628041

GI number: 169628041

Start: 950775

End: 952052

Strand: Direct

Name: gltA [H]

Synonym: MAB_0944

Alternate gene names: 169628041

Gene position: 950775-952052 (Clockwise)

Preceding gene: 169628040

Following gene: 169628042

Centisome position: 18.76

GC content: 64.4

Gene sequence:

>1278_bases
GTGGCCGACAACAATGATTTCGCTACTCTCCAGTACCCCGGAGGCGAAACCAAGCTGGATATCGTCCGCGCGACCGAAGG
TGCCGATGGGTTCGCGCTGGGCAAGCTGCTGGCTGACACGGGCTACACCACGTTCGATGCGGGTTTCGTCAACACCGCAT
CGACGAAGAGCGCCATCACCTACATCGACGGGGACGCCGGCATCCTGCGTTACCGCGGTTACCCGATTGAGCAGCTCGCC
GACAAGTCCACCTTCATCGAGGTGAGCTACCTGCTCATCTACGGTGAGCTGCCCACCCCGCAGCAGCTGGAGGACTTCAC
CACCAAGATCCAGCGCCACACGCTGCTGCACGAGGACCTCAAGCGGTTCTTCGACGGCTTCCCGCGCAATGCGCACCCCA
TGCCGGTGCTCTCCAGTGCCGCGAACGCGCTGAGCGCGTACTACCAGGACTCGCTGGACCCGCATGATGACGCACAGGTC
GAGCTGTCCACGATCCGGTTGCTCGCCAAGCTGCCGACGATCGCGGCCTATGCCTACAAGAAGTCGGTCGGGCAGCCGTT
CCTGTACCCGGACAACACGCTGACCCTCGTCGAGAACTTCCTGCGGATGACCTTCGGCCTTCCCGCCGAGCCGTACGAGG
TCGACCCGGAGATCGTGAGGGCCCTGGACATGCTGCTCATCCTGCATGCCGACCACGAGCAGAACTGCTCCACCTCGACG
GTGCGTTTGGTCGGCTCCTCGGACGCCAACTTGTTCACCTCCGTGTCCGGCGGCATCAACGCGCTGTGGGGCCCGCTGCA
CGGCGGTGCCAACCAGGCGGTGCTGGAGATGCTCGAGCGCATCCGCTCGGAGGGCGGCGATACCCACGACTTCGTGCGCC
GGGTGAAGAACCGCGAAGACGGCGTCAAGCTCATGGGCTTCGGGCACCGCGTCTACAAGAACTACGACCCGCGCGCCCGG
ATCTGTAAGGAACAGGCCGATAAGATCCTGGGCAAGCTCGGCGGCGATGACCAGCTGCTCGAGATCGCCAAGGCCCTCGA
GGAAGCCGCGCTCACCGACGACTACTTCGTCGAGCGCAAGCTGTACCCGAACGTCGACTTCTACACCGGACTGATCTACC
GGGCCATCGGCTTCCCGACGCGCATGTTCACCGTGCTGTTCGCGTTGGGCCGCTTGCCCGGCTGGATCGCGCACTGGCGT
GAGATGCATTCGGAGCCGGGCAAGATCGGCCGCCCGCGGCAGATCTACACCGGCTATGGGGAGCGTCAGTACCCCTGA

Upstream 100 bases:

>100_bases
CGGCAGCCGCCTGGACCCCCGAGCCCGACCCTGACCAGGCGGCCCGGAGGCGGAGCGACTACCTTCTTCTCTAGCCCGCT
CAACCTCAGAAGGGATGCCT

Downstream 100 bases:

>100_bases
TCTGTGCCGGTCGCGTAGCGGCCGATCTGACACTGTGATCTGACACAGTGATCTGACACAGTGATCTGACACTGTGACGC
AAGTCTGTTTGCATTGCTAA

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MADNNDFATLQYPGGETKLDIVRATEGADGFALGKLLADTGYTTFDAGFVNTASTKSAITYIDGDAGILRYRGYPIEQLA
DKSTFIEVSYLLIYGELPTPQQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAANALSAYYQDSLDPHDDAQV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNTLTLVENFLRMTFGLPAEPYEVDPEIVRALDMLLILHADHEQNCSTST
VRLVGSSDANLFTSVSGGINALWGPLHGGANQAVLEMLERIRSEGGDTHDFVRRVKNREDGVKLMGFGHRVYKNYDPRAR
ICKEQADKILGKLGGDDQLLEIAKALEEAALTDDYFVERKLYPNVDFYTGLIYRAIGFPTRMFTVLFALGRLPGWIAHWR
EMHSEPGKIGRPRQIYTGYGERQYP

Sequences:

>Translated_425_residues
MADNNDFATLQYPGGETKLDIVRATEGADGFALGKLLADTGYTTFDAGFVNTASTKSAITYIDGDAGILRYRGYPIEQLA
DKSTFIEVSYLLIYGELPTPQQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAANALSAYYQDSLDPHDDAQV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNTLTLVENFLRMTFGLPAEPYEVDPEIVRALDMLLILHADHEQNCSTST
VRLVGSSDANLFTSVSGGINALWGPLHGGANQAVLEMLERIRSEGGDTHDFVRRVKNREDGVKLMGFGHRVYKNYDPRAR
ICKEQADKILGKLGGDDQLLEIAKALEEAALTDDYFVERKLYPNVDFYTGLIYRAIGFPTRMFTVLFALGRLPGWIAHWR
EMHSEPGKIGRPRQIYTGYGERQYP
>Mature_424_residues
ADNNDFATLQYPGGETKLDIVRATEGADGFALGKLLADTGYTTFDAGFVNTASTKSAITYIDGDAGILRYRGYPIEQLAD
KSTFIEVSYLLIYGELPTPQQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAANALSAYYQDSLDPHDDAQVE
LSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNTLTLVENFLRMTFGLPAEPYEVDPEIVRALDMLLILHADHEQNCSTSTV
RLVGSSDANLFTSVSGGINALWGPLHGGANQAVLEMLERIRSEGGDTHDFVRRVKNREDGVKLMGFGHRVYKNYDPRARI
CKEQADKILGKLGGDDQLLEIAKALEEAALTDDYFVERKLYPNVDFYTGLIYRAIGFPTRMFTVLFALGRLPGWIAHWRE
MHSEPGKIGRPRQIYTGYGERQYP

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=391, Percent_Identity=29.156010230179, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786939, Length=426, Percent_Identity=53.5211267605634, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=32.4324324324324, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17555174, Length=386, Percent_Identity=30.0518134715026, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=343, Percent_Identity=27.6967930029155, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=382, Percent_Identity=26.9633507853403, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325257, Length=402, Percent_Identity=25.6218905472637, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24640126, Length=409, Percent_Identity=29.3398533007335, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24640124, Length=409, Percent_Identity=29.3398533007335, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21356863, Length=387, Percent_Identity=27.390180878553, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47552; Mature: 47421

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNNDFATLQYPGGETKLDIVRATEGADGFALGKLLADTGYTTFDAGFVNTASTKSAIT
CCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCEEE
YIDGDAGILRYRGYPIEQLADKSTFIEVSYLLIYGELPTPQQLEDFTTKIQRHTLLHEDL
EEECCCCEEEECCCCHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KRFFDGFPRNAHPMPVLSSAANALSAYYQDSLDPHDDAQVELSTIRLLAKLPTIAAYAYK
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSVGQPFLYPDNTLTLVENFLRMTFGLPAEPYEVDPEIVRALDMLLILHADHEQNCSTST
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCE
VRLVGSSDANLFTSVSGGINALWGPLHGGANQAVLEMLERIRSEGGDTHDFVRRVKNRED
EEEEECCCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GVKLMGFGHRVYKNYDPRARICKEQADKILGKLGGDDQLLEIAKALEEAALTDDYFVERK
CEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHH
LYPNVDFYTGLIYRAIGFPTRMFTVLFALGRLPGWIAHWREMHSEPGKIGRPRQIYTGYG
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCC
ERQYP
CCCCC
>Mature Secondary Structure 
ADNNDFATLQYPGGETKLDIVRATEGADGFALGKLLADTGYTTFDAGFVNTASTKSAIT
CCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCEEE
YIDGDAGILRYRGYPIEQLADKSTFIEVSYLLIYGELPTPQQLEDFTTKIQRHTLLHEDL
EEECCCCEEEECCCCHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KRFFDGFPRNAHPMPVLSSAANALSAYYQDSLDPHDDAQVELSTIRLLAKLPTIAAYAYK
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSVGQPFLYPDNTLTLVENFLRMTFGLPAEPYEVDPEIVRALDMLLILHADHEQNCSTST
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCE
VRLVGSSDANLFTSVSGGINALWGPLHGGANQAVLEMLERIRSEGGDTHDFVRRVKNRED
EEEEECCCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GVKLMGFGHRVYKNYDPRARICKEQADKILGKLGGDDQLLEIAKALEEAALTDDYFVERK
CEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHH
LYPNVDFYTGLIYRAIGFPTRMFTVLFALGRLPGWIAHWREMHSEPGKIGRPRQIYTGYG
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCC
ERQYP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]