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The map label for this gene is pdhA [H]

Identifier: 169627996

GI number: 169627996

Start: 890231

End: 891355

Strand: Reverse

Name: pdhA [H]

Synonym: MAB_0897c

Alternate gene names: 169627996

Gene position: 891355-890231 (Counterclockwise)

Preceding gene: 169627998

Following gene: 169627995

Centisome position: 17.59

GC content: 64.09

Gene sequence:

>1125_bases
GTGACGGTGGCCGAACCGGCTGACCGACCGGCGTATCAAGCGTTCCTTCCCGCCGACTCCGCGGTGCAGTTTCTTGACCC
CGAGGGTCGGCCCGTCGACGGCGGCGCCCGGTACCCCCGGCCTGATGCCGATCGACTGTTGGCAATGTACCGAAACATGG
TGCTGGGACGTCGCTTTGACGAGCAGGCAACAGCTTTGACCAAGCAGGGGCGACTGGCGGTATATCCGTCGTCGCGCGGG
CAGGAAGCCTGCCAGATCGCGGCGGCAATGTGCCTGCACTCCGACGACTGGCTGTTCCCCACCTACCGCGATTCGATGGC
GCTGGCGGCTCGAGGCATCGACACCGTCGATATCCTCCGATTCCTCGCGGGCGACTGGCACTGCTGCTTCGATCCCGCTC
AGCACCGCACCGCTCCCCAAGCCACCCCACTTGCCACACAACTTCTACACGCGGCCGGGCTCGCCCATGCGCTGGCTCGC
AAAGGCAGCGACACTGCGGTGCTGGCGCTGTGTGGCGACGGCGCAACCAGCGAAGGCGACTTCCACGAAGCCCTCAACTT
CGCCGCGGTCTTTCGGGCGCCGGTAATCTTCCTGGTCCAGAACAATGGTTTTGCCATCAGCGTTCCGCTGGCCCGTCAGT
CCGTGGCTCCATCATTGGCCCACAAAGGAATTGGGTATGGAATGGGCAGCGAGCAGGTCGACGGAAACGATCCGGTCGCG
ATGCTCGCGGTGCTCGATGCAGCCAGAGAGTACGTACTGGCCGGCAACGGTCCTGTCATCGTTGAAGCCCACACCTATCG
GATGTCGGGACATACCAATGCAGACGATCCACTCCGCTACCGCACCGATGACGAACTGGACGAGTGGCTGGCGCGCGATC
CCATCCAACGACTGGAAATCCATCTGCGTGCCGAAGGACTGCTGGACGATACCTACGTCGCAGCCGTGGCGTCCGATGCC
GAAGACCTCGCAGCCACTACCAGGGCGGGCATGAATCGCGATCGACCCGTCGACGTCGACGACCTGTTCCGATACGTCTA
CGCGCAGCCGACCTCCCAACTTCGTGAGCAGCACGCACAGGCCCGCGCCGACTTCACCGCCCAACTCTCAGAGGACCGCC
CATGA

Upstream 100 bases:

>100_bases
GCCTAGTTCGTCAATTGATCCTCAGTATCTCGAAATAGGTTGTCAACTACGTCGCCACTGCGCACGATCGTAAGACAGAT
TGTGAATAATGGAGGTAAAT

Downstream 100 bases:

>100_bases
CCGTGACCACTATGGCGCAAGCTCTCAACGCTGCATTGCGCGATGCGCTGCACGACGACGATTCGGTGGTGGTGTTCGGC
GAGGACGTCGGCACGTTGGG

Product: pyruvate dehydrogenase E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGGARYPRPDADRLLAMYRNMVLGRRFDEQATALTKQGRLAVYPSSRG
QEACQIAAAMCLHSDDWLFPTYRDSMALAARGIDTVDILRFLAGDWHCCFDPAQHRTAPQATPLATQLLHAAGLAHALAR
KGSDTAVLALCGDGATSEGDFHEALNFAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVA
MLAVLDAAREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQRLEIHLRAEGLLDDTYVAAVASDA
EDLAATTRAGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQARADFTAQLSEDRP

Sequences:

>Translated_374_residues
MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGGARYPRPDADRLLAMYRNMVLGRRFDEQATALTKQGRLAVYPSSRG
QEACQIAAAMCLHSDDWLFPTYRDSMALAARGIDTVDILRFLAGDWHCCFDPAQHRTAPQATPLATQLLHAAGLAHALAR
KGSDTAVLALCGDGATSEGDFHEALNFAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVA
MLAVLDAAREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQRLEIHLRAEGLLDDTYVAAVASDA
EDLAATTRAGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQARADFTAQLSEDRP
>Mature_373_residues
TVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGGARYPRPDADRLLAMYRNMVLGRRFDEQATALTKQGRLAVYPSSRGQ
EACQIAAAMCLHSDDWLFPTYRDSMALAARGIDTVDILRFLAGDWHCCFDPAQHRTAPQATPLATQLLHAAGLAHALARK
GSDTAVLALCGDGATSEGDFHEALNFAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVAM
LAVLDAAREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQRLEIHLRAEGLLDDTYVAAVASDAE
DLAATTRAGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQARADFTAQLSEDRP

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=333, Percent_Identity=32.1321321321321, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=32.1321321321321, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4885543, Length=319, Percent_Identity=27.5862068965517, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4505685, Length=262, Percent_Identity=30.9160305343511, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI291084742, Length=319, Percent_Identity=28.5266457680251, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI291084744, Length=269, Percent_Identity=29.7397769516729, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI291084757, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563357, Length=330, Percent_Identity=31.2121212121212, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI86563355, Length=330, Percent_Identity=31.2121212121212, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17536047, Length=292, Percent_Identity=29.7945205479452, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32564172, Length=292, Percent_Identity=29.7945205479452, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321026, Length=345, Percent_Identity=28.4057971014493, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355903, Length=335, Percent_Identity=32.2388059701493, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24639744, Length=329, Percent_Identity=28.2674772036474, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28571106, Length=329, Percent_Identity=28.2674772036474, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24639740, Length=329, Percent_Identity=28.2674772036474, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=28.5245901639344, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24639748, Length=325, Percent_Identity=26.7692307692308, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40761; Mature: 40630

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGGARYPRPDADRLLAMYRNMVLGRRFD
CCCCCCCCCCCCEEECCCCCCHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EQATALTKQGRLAVYPSSRGQEACQIAAAMCLHSDDWLFPTYRDSMALAARGIDTVDILR
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHH
FLAGDWHCCFDPAQHRTAPQATPLATQLLHAAGLAHALARKGSDTAVLALCGDGATSEGD
HHHCCCEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
FHEALNFAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVA
HHHHHHHHHHHHCCEEEEEECCCEEEEECCHHHHHCHHHHHCCCCCCCCCCCCCCCCCHH
MLAVLDAAREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQRLEI
HHHHHHHHHHEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHEE
HLRAEGLLDDTYVAAVASDAEDLAATTRAGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQ
EEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
ARADFTAQLSEDRP
HHHCHHHHHCCCCC
>Mature Secondary Structure 
TVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGGARYPRPDADRLLAMYRNMVLGRRFD
CCCCCCCCCCCEEECCCCCCHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EQATALTKQGRLAVYPSSRGQEACQIAAAMCLHSDDWLFPTYRDSMALAARGIDTVDILR
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHH
FLAGDWHCCFDPAQHRTAPQATPLATQLLHAAGLAHALARKGSDTAVLALCGDGATSEGD
HHHCCCEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
FHEALNFAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVA
HHHHHHHHHHHHCCEEEEEECCCEEEEECCHHHHHCHHHHHCCCCCCCCCCCCCCCCCHH
MLAVLDAAREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQRLEI
HHHHHHHHHHEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHEE
HLRAEGLLDDTYVAAVASDAEDLAATTRAGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQ
EEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
ARADFTAQLSEDRP
HHHCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]