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The map label for this gene is pdhB [H]

Identifier: 169627995

GI number: 169627995

Start: 889230

End: 890234

Strand: Reverse

Name: pdhB [H]

Synonym: MAB_0896c

Alternate gene names: 169627995

Gene position: 890234-889230 (Counterclockwise)

Preceding gene: 169627996

Following gene: 169627994

Centisome position: 17.57

GC content: 64.08

Gene sequence:

>1005_bases
ATGACCGTGACCACTATGGCGCAAGCTCTCAACGCTGCATTGCGCGATGCGCTGCACGACGACGATTCGGTGGTGGTGTT
CGGCGAGGACGTCGGCACGTTGGGGGGTGTCTTCCGGGTCACCGATGGTCTTACCGAAACCTTCGGCGCCAACAGGTGTT
TCGATACTCCGCTGGCAGAATCGGGAATCATCGGGTTCGCGGTGGGTATGGCGATGGGGGGCTTTCGCCCGGTGGTCGAG
ATGCAATTCGACGCCTTCGCCTATCCCGCGTTTGAACAAGTCGTGTCCCACGTGGCCAAACTGCGCAATCGCACCCGCGG
TGTGCTCTCTGTGCCCATGGTGATCCGGGTGCCCTACGCCGGCGGTATCGGAGGCGTCGAACACCACTGCGACTCCAGCG
AGGCCTACTATGCGCACACGCCGGGACTGAAGGTGGTCACACCGGCAACCGTCGCGGACGCCTACGGGCTCCTCAGGGAA
GCTATCGACGATCCCGATCCCGTCGTTTTCCTTGAGCCCAAAAGGCTGTACTTCTCCCGCGCCGACGTCGAACTGGGTCG
AGGTGCCAAAATCGGCGAGGCGCAGGTGCTGCGTGCCGGGACCGATGTCACGCTGATCGCCTACGGCCCGTCGGTGGAAC
CTGCGCTGCAGGCAGCCGCCGCAGCCGCCGACGAAGGCCGAGATATCGAAGTCGTCGACCTTCGGTCCATCGCACCCTTT
GACGACCAGAGCGTGACGGCTTCCGTCCGCAAGACCGGCCGTTGCGTAATCGTCCAGGAGGCGCAGGGTTTCGGTGGCGT
CGGCGCCGAGATCGCTGCTCGGATCCAGGAGCGCTGTTTCCATCACCTGGCAGCACCTGTTCTGCGCGTCTCCGGATACG
ACATCCCCTACCCCGCGCCTAGGCTCGAGCGATGGTATCTGCCCAGTACCGACCGCATCCTCGACGCGGTCGATCGCCTG
CAATGGGACGACCACCCCGATAGCCGTTGGGTGGTCAGCGCATGA

Upstream 100 bases:

>100_bases
ACCTGTTCCGATACGTCTACGCGCAGCCGACCTCCCAACTTCGTGAGCAGCACGCACAGGCCCGCGCCGACTTCACCGCC
CAACTCTCAGAGGACCGCCC

Downstream 100 bases:

>100_bases
CCGCTCAGACATTCAACCTGCCCGACCTCGGCGAAGGTCTCACGGAAGCGATCATCATCAAATGGCTAGTGTCGGTCGGC
GACACCGTCGTCATCGATCA

Product: putative pyruvate dehydrogenase E1 component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTVTTMAQALNAALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAESGIIGFAVGMAMGGFRPVVE
MQFDAFAYPAFEQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKVVTPATVADAYGLLRE
AIDDPDPVVFLEPKRLYFSRADVELGRGAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADEGRDIEVVDLRSIAPF
DDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAPVLRVSGYDIPYPAPRLERWYLPSTDRILDAVDRL
QWDDHPDSRWVVSA

Sequences:

>Translated_334_residues
MTVTTMAQALNAALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAESGIIGFAVGMAMGGFRPVVE
MQFDAFAYPAFEQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKVVTPATVADAYGLLRE
AIDDPDPVVFLEPKRLYFSRADVELGRGAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADEGRDIEVVDLRSIAPF
DDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAPVLRVSGYDIPYPAPRLERWYLPSTDRILDAVDRL
QWDDHPDSRWVVSA
>Mature_333_residues
TVTTMAQALNAALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAESGIIGFAVGMAMGGFRPVVEM
QFDAFAYPAFEQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKVVTPATVADAYGLLREA
IDDPDPVVFLEPKRLYFSRADVELGRGAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADEGRDIEVVDLRSIAPFD
DQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAPVLRVSGYDIPYPAPRLERWYLPSTDRILDAVDRLQ
WDDHPDSRWVVSA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=321, Percent_Identity=40.1869158878505, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI34101272, Length=321, Percent_Identity=40.1869158878505, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI156564403, Length=322, Percent_Identity=37.5776397515528, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI291084858, Length=322, Percent_Identity=36.0248447204969, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1786622, Length=255, Percent_Identity=25.0980392156863, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17506935, Length=322, Percent_Identity=41.9254658385093, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=39.3846153846154, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319698, Length=323, Percent_Identity=37.4613003095975, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI160714828, Length=321, Percent_Identity=43.613707165109, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI160714832, Length=321, Percent_Identity=43.613707165109, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21358145, Length=319, Percent_Identity=43.2601880877743, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24650940, Length=319, Percent_Identity=43.2601880877743, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24650943, Length=88, Percent_Identity=43.1818181818182, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650945, Length=88, Percent_Identity=43.1818181818182, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35971; Mature: 35840

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTTMAQALNAALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAE
CCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHECCCHHHHCCCCCCCCCCCCC
SGIIGFAVGMAMGGFRPVVEMQFDAFAYPAFEQVVSHVAKLRNRTRGVLSVPMVIRVPYA
CCHHHHHHHHHHCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHCCCEEECCEEEEECCC
GGIGGVEHHCDSSEAYYAHTPGLKVVTPATVADAYGLLREAIDDPDPVVFLEPKRLYFSR
CCCCCHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCEEEECCHHHEEEE
ADVELGRGAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADEGRDIEVVDLRSIAPF
CCEECCCCCCCCCHHEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCC
DDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAPVLRVSGYDIPYPAP
CCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCC
RLERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA
CCCEECCCCHHHHHHHHHHCCCCCCCCCCEEECC
>Mature Secondary Structure 
TVTTMAQALNAALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAE
CHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHECCCHHHHCCCCCCCCCCCCC
SGIIGFAVGMAMGGFRPVVEMQFDAFAYPAFEQVVSHVAKLRNRTRGVLSVPMVIRVPYA
CCHHHHHHHHHHCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHCCCEEECCEEEEECCC
GGIGGVEHHCDSSEAYYAHTPGLKVVTPATVADAYGLLREAIDDPDPVVFLEPKRLYFSR
CCCCCHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCEEEECCHHHEEEE
ADVELGRGAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADEGRDIEVVDLRSIAPF
CCEECCCCCCCCCHHEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCC
DDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAPVLRVSGYDIPYPAP
CCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCC
RLERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA
CCCEECCCCHHHHHHHHHHCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA