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The map label for this gene is hpd [H]

Identifier: 169627992

GI number: 169627992

Start: 885296

End: 886501

Strand: Direct

Name: hpd [H]

Synonym: MAB_0893

Alternate gene names: 169627992

Gene position: 885296-886501 (Clockwise)

Preceding gene: 169627981

Following gene: 169627997

Centisome position: 17.47

GC content: 60.7

Gene sequence:

>1206_bases
ATGACCATCGAGCACACATTGACCAACGAAGAGCTGCTGGCCGGGCTCGACGGTGAACAGCTGAGGCAGCTCGTGGGGTT
GGTGGACTACGACGCCGACGCCGACCCGTTCCCGGTCCAAGGCTGGGACTCGATTGGGTGGGTCGTGGGCAATGCGGCGC
AGACCGCGCATTTCTTTCAGTCGGCCTTCGGCATGGAGTTGGTGGCCTACTCCGGTCCCACCACCGGTAATCGCGAGCAT
CATTCATTTGTCTTGCGTTCGGGGGCAATACGTTTCGTGATCAATGGTGCGGTTGATCCCGCGAGCCCGTTGGCCGACCA
TCACCGCAGGCACGGTGATGGTGTCGTCGATATCGCGCTCACAGTGCCAGACGTCGACAAGTGCATCGATCATGCCCGCG
CTCAGGGAGCCACCGTGCTCGTGGAGCCACACGATGTCACCGACGAATTCGGGACCGTGCGGTTGGCTGCGATCGCGACG
TACGGCGAGACCCGCCACACTCTCGTGCAGCGCTCGCAGTACACCGGGCCCTACCTTCCCGGCTATGTCGCACGCACCTC
CGCATACCGCAAACGTGCGGATGCGCCGAAGCGGATCTTTCAGGCGCTCGATCACGTGGTGGGCAACGTCGAGCTTGGCA
AAATGAACGAATGGGTGGCCTTCTACAACCGCGTCATGGGCTTCACCAACATGGCCGAATTCGTCGGCGAGGACATCGCG
ACCGATTACTCGGCGCTCATGAGCAAGGTTGTGTGCAACGGCAATCACCGGGTGAAGTTTCCGCTCAACGAGCCGGCGAT
CGCGAAGAAGCGTTCACAAATCGACGAGTACCTGGAGTTCTATCACGGCCCCGGTGTGCAGCATTTAGCGTTGGCCACCA
ACGATATTCTCGCTACGGTCGATGCCCTGCGTGAGGAAGGGATCGAATTTCTCGCCACGCCGGACTCCTACTACGAAGAC
CCCGAACTGCGGGCACGTATTGGCCAGGTGCGTGTTCCGATCGAGGAACTGCAAAAGCGGGGAATCCTGGTGGACCGCGA
CGAGGACGGTTACCTCCTTCAGATCTTCACCAGGCCTCTGGTGGACCGCCCGACAGTGTTTTTCGAGCTCATCGAGCGTC
ACGGCTCCCTGGGATTTGGGATCGGCAATTTCAAGGCGCTCTTCGAGGCCATCGAGCGTGAACAGGATGCCCGCGGAAAC
CTGTGA

Upstream 100 bases:

>100_bases
GTATACCTAGGTTGCGCCGCCAACGTGCGCGTCCACTAATGAGCAGCACGCCGTTTTTCACGGCGTCGCCCACATCCCAC
CGCTTTGGAGAGGCCGCTAT

Downstream 100 bases:

>100_bases
CGAGGCGTGCCCGCAACCCCGACCGATCACCGGTCGGGGTTGCGTCTACGCCAATTCAATGACAATGTCCGCCCGCTTTG
CGGGTGACTGCTCGCGAATG

Product: putative 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTIEHTLTNEELLAGLDGEQLRQLVGLVDYDADADPFPVQGWDSIGWVVGNAAQTAHFFQSAFGMELVAYSGPTTGNREH
HSFVLRSGAIRFVINGAVDPASPLADHHRRHGDGVVDIALTVPDVDKCIDHARAQGATVLVEPHDVTDEFGTVRLAAIAT
YGETRHTLVQRSQYTGPYLPGYVARTSAYRKRADAPKRIFQALDHVVGNVELGKMNEWVAFYNRVMGFTNMAEFVGEDIA
TDYSALMSKVVCNGNHRVKFPLNEPAIAKKRSQIDEYLEFYHGPGVQHLALATNDILATVDALREEGIEFLATPDSYYED
PELRARIGQVRVPIEELQKRGILVDRDEDGYLLQIFTRPLVDRPTVFFELIERHGSLGFGIGNFKALFEAIEREQDARGN
L

Sequences:

>Translated_401_residues
MTIEHTLTNEELLAGLDGEQLRQLVGLVDYDADADPFPVQGWDSIGWVVGNAAQTAHFFQSAFGMELVAYSGPTTGNREH
HSFVLRSGAIRFVINGAVDPASPLADHHRRHGDGVVDIALTVPDVDKCIDHARAQGATVLVEPHDVTDEFGTVRLAAIAT
YGETRHTLVQRSQYTGPYLPGYVARTSAYRKRADAPKRIFQALDHVVGNVELGKMNEWVAFYNRVMGFTNMAEFVGEDIA
TDYSALMSKVVCNGNHRVKFPLNEPAIAKKRSQIDEYLEFYHGPGVQHLALATNDILATVDALREEGIEFLATPDSYYED
PELRARIGQVRVPIEELQKRGILVDRDEDGYLLQIFTRPLVDRPTVFFELIERHGSLGFGIGNFKALFEAIEREQDARGN
L
>Mature_400_residues
TIEHTLTNEELLAGLDGEQLRQLVGLVDYDADADPFPVQGWDSIGWVVGNAAQTAHFFQSAFGMELVAYSGPTTGNREHH
SFVLRSGAIRFVINGAVDPASPLADHHRRHGDGVVDIALTVPDVDKCIDHARAQGATVLVEPHDVTDEFGTVRLAAIATY
GETRHTLVQRSQYTGPYLPGYVARTSAYRKRADAPKRIFQALDHVVGNVELGKMNEWVAFYNRVMGFTNMAEFVGEDIAT
DYSALMSKVVCNGNHRVKFPLNEPAIAKKRSQIDEYLEFYHGPGVQHLALATNDILATVDALREEGIEFLATPDSYYEDP
ELRARIGQVRVPIEELQKRGILVDRDEDGYLLQIFTRPLVDRPTVFFELIERHGSLGFGIGNFKALFEAIEREQDARGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=363, Percent_Identity=44.0771349862259, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI285002264, Length=344, Percent_Identity=43.8953488372093, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI14249394, Length=360, Percent_Identity=29.7222222222222, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555220, Length=371, Percent_Identity=44.743935309973, Blast_Score=300, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI17550752, Length=364, Percent_Identity=33.7912087912088, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24667510, Length=363, Percent_Identity=42.6997245179063, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI21356105, Length=294, Percent_Identity=45.578231292517, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 44622; Mature: 44491

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEHTLTNEELLAGLDGEQLRQLVGLVDYDADADPFPVQGWDSIGWVVGNAAQTAHFFQ
CCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHH
SAFGMELVAYSGPTTGNREHHSFVLRSGAIRFVINGAVDPASPLADHHRRHGDGVVDIAL
HHHCCEEEEECCCCCCCCCHHHHHEECCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEE
TVPDVDKCIDHARAQGATVLVEPHDVTDEFGTVRLAAIATYGETRHTLVQRSQYTGPYLP
ECCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCC
GYVARTSAYRKRADAPKRIFQALDHVVGNVELGKMNEWVAFYNRVMGFTNMAEFVGEDIA
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
TDYSALMSKVVCNGNHRVKFPLNEPAIAKKRSQIDEYLEFYHGPGVQHLALATNDILATV
HHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
DALREEGIEFLATPDSYYEDPELRARIGQVRVPIEELQKRGILVDRDEDGYLLQIFTRPL
HHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHCCCEEECCCCCCEEEEECCCC
VDRPTVFFELIERHGSLGFGIGNFKALFEAIEREQDARGNL
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TIEHTLTNEELLAGLDGEQLRQLVGLVDYDADADPFPVQGWDSIGWVVGNAAQTAHFFQ
CCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHH
SAFGMELVAYSGPTTGNREHHSFVLRSGAIRFVINGAVDPASPLADHHRRHGDGVVDIAL
HHHCCEEEEECCCCCCCCCHHHHHEECCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEE
TVPDVDKCIDHARAQGATVLVEPHDVTDEFGTVRLAAIATYGETRHTLVQRSQYTGPYLP
ECCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCC
GYVARTSAYRKRADAPKRIFQALDHVVGNVELGKMNEWVAFYNRVMGFTNMAEFVGEDIA
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
TDYSALMSKVVCNGNHRVKFPLNEPAIAKKRSQIDEYLEFYHGPGVQHLALATNDILATV
HHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
DALREEGIEFLATPDSYYEDPELRARIGQVRVPIEELQKRGILVDRDEDGYLLQIFTRPL
HHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHCCCEEECCCCCCEEEEECCCC
VDRPTVFFELIERHGSLGFGIGNFKALFEAIEREQDARGNL
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]