Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 169627949

GI number: 169627949

Start: 844202

End: 845410

Strand: Direct

Name: fadA [H]

Synonym: MAB_0850

Alternate gene names: 169627949

Gene position: 844202-845410 (Clockwise)

Preceding gene: 169627945

Following gene: 169627950

Centisome position: 16.66

GC content: 67.66

Gene sequence:

>1209_bases
ATGACTGAAGCATTCATCTACGAGGCCGTCCGTACGCCTCGCGGCAAGCAGCGTGGCGGCGCTCTCAACGAGATCAAGCC
GCTGAACCTGGTGGTCGGCCTCATCGAGGAGATCCGGCACCGTCACCCCGACCTGGACGAGAACCTGATCAGCGATGTCG
TGCTGGGTGTCGTGTCCCCGGTCGGCGACCAGGGTGGCGATATCGCCCGCACCGCGGTGCTGGCGGCCGGCCTGCCCGAC
ACCACCGGTGGTGTCCAGCTCAACCGTTTCTGTGCCTCGGGCCTGGAGGCCATCAACATCGGCGCACAGAAGGTGCGTTC
CGGCTGGGACGACCTGGTGCTCGCCGGTGGTGTGGAGTCGATGTCGCGCGTGCCGATGGGCAGCGACGGCGGCGCGTGGG
CGTCGGACCCGGCCACCAACTACGACGTGTCCTTCGTTCCGCAGGGCATCGGTGCCGACTTGATCGCCACTATCGAGGGC
TTCACCCGTGACGATGTGGACGCCTACGCCGCCCGCTCGCAGGAGCGTGCCGCGGCCGCGTGGTCCGGTGGCTACTTCGC
CAAGTCCGTTGTGCCGGTCAAGGATCAGAACGGGCTGCTCGTTCTCGATCACGACGAGCACATGCGCCCGGGCACCACCG
CGGCAGACCTGGGCAAGCTCAAGCCCGCGTTCGAGGGCCTGGCCGCGCTCGGCGGCTTCGACGACGTGGCGCGCATCAAG
TACCACTACGTCGAGAAGATCAACCACGTCCACACCGGTGGCAACAGCTCCGGCATCGTCGACGGCGCCGCCCTGGTGCT
GATCGGTTCCGAGGAGGCCGGCAAGTCGCAGGGCCTGACCCCGCGCGCTCGTATCGTGGCCACCGCCACCTCCGGCAGCG
AGCCGCTCATCATGCTGACCGGTCCCACCCCGGCGACCAAGAAGGTGCTCGACCGTGCCGGGCTGACCGTGGACGACATC
GACCTGTTCGAGCTCAACGAGGCCTTCGCCTCGGTGGTCCTGAAGTTCCAGAAGGACCTGAACATCCCGGACGAGAAGCT
CAACGTCAACGGCGGCGCCATCGCGATGGGCCACCCGCTGGGCGCCACCGGCGCCATGATCACCGGCACCATGGTCGACG
AGCTGGAGCGTCGCGGCCTCAAGCGTGCCCTCATCACCCTGTGCGTCGGCGGCGGCATGGGTGTAGCCACCATCATCGAG
CGAGTCTGA

Upstream 100 bases:

>100_bases
TAGGGCTGTCTCGGCGAAACTGACCCGGAGTCAATCCGGGTTCTGGGCCGGGGCACCTGCACCACATGCCCCCATACGCA
CCGGATAAGGACGTATACCC

Downstream 100 bases:

>100_bases
GCTAAGGGAGCGAGAACTTATGTCTGCAAACACCATTCAGTGGGAGAAGGACGCCGACGGCATCGTCACCCTCACCCTGG
ACGACCCCAACGGCTCGGCC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTEAFIYEAVRTPRGKQRGGALNEIKPLNLVVGLIEEIRHRHPDLDENLISDVVLGVVSPVGDQGGDIARTAVLAAGLPD
TTGGVQLNRFCASGLEAINIGAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWASDPATNYDVSFVPQGIGADLIATIEG
FTRDDVDAYAARSQERAAAAWSGGYFAKSVVPVKDQNGLLVLDHDEHMRPGTTAADLGKLKPAFEGLAALGGFDDVARIK
YHYVEKINHVHTGGNSSGIVDGAALVLIGSEEAGKSQGLTPRARIVATATSGSEPLIMLTGPTPATKKVLDRAGLTVDDI
DLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGLKRALITLCVGGGMGVATIIE
RV

Sequences:

>Translated_402_residues
MTEAFIYEAVRTPRGKQRGGALNEIKPLNLVVGLIEEIRHRHPDLDENLISDVVLGVVSPVGDQGGDIARTAVLAAGLPD
TTGGVQLNRFCASGLEAINIGAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWASDPATNYDVSFVPQGIGADLIATIEG
FTRDDVDAYAARSQERAAAAWSGGYFAKSVVPVKDQNGLLVLDHDEHMRPGTTAADLGKLKPAFEGLAALGGFDDVARIK
YHYVEKINHVHTGGNSSGIVDGAALVLIGSEEAGKSQGLTPRARIVATATSGSEPLIMLTGPTPATKKVLDRAGLTVDDI
DLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGLKRALITLCVGGGMGVATIIE
RV
>Mature_401_residues
TEAFIYEAVRTPRGKQRGGALNEIKPLNLVVGLIEEIRHRHPDLDENLISDVVLGVVSPVGDQGGDIARTAVLAAGLPDT
TGGVQLNRFCASGLEAINIGAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAWASDPATNYDVSFVPQGIGADLIATIEGF
TRDDVDAYAARSQERAAAAWSGGYFAKSVVPVKDQNGLLVLDHDEHMRPGTTAADLGKLKPAFEGLAALGGFDDVARIKY
HYVEKINHVHTGGNSSGIVDGAALVLIGSEEAGKSQGLTPRARIVATATSGSEPLIMLTGPTPATKKVLDRAGLTVDDID
LFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGLKRALITLCVGGGMGVATIIER
V

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=413, Percent_Identity=36.8038740920097, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI148539872, Length=409, Percent_Identity=35.4523227383863, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI4501853, Length=368, Percent_Identity=36.6847826086957, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI4557237, Length=420, Percent_Identity=33.5714285714286, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=28.9592760180996, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI194353979, Length=90, Percent_Identity=53.3333333333333, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=42.4528301886792, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=37.9901960784314, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788554, Length=417, Percent_Identity=37.410071942446, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082165, Length=426, Percent_Identity=36.150234741784, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=28.5377358490566, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI133906874, Length=412, Percent_Identity=35.4368932038835, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=413, Percent_Identity=33.6561743341404, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI25147385, Length=414, Percent_Identity=32.3671497584541, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17551802, Length=460, Percent_Identity=27.3913043478261, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17535917, Length=410, Percent_Identity=28.2926829268293, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=35.4114713216958, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=29.6116504854369, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24655093, Length=416, Percent_Identity=37.5, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI17648125, Length=370, Percent_Identity=35.4054054054054, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24640423, Length=366, Percent_Identity=32.7868852459016, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137578, Length=447, Percent_Identity=29.5302013422819, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42052; Mature: 41921

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAFIYEAVRTPRGKQRGGALNEIKPLNLVVGLIEEIRHRHPDLDENLISDVVLGVVSP
CCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
VGDQGGDIARTAVLAAGLPDTTGGVQLNRFCASGLEAINIGAQKVRSGWDDLVLAGGVES
CCCCCCCHHHHHHHHCCCCCCCCCEEHHHHHHCCHHEECCCHHHHHCCCCCEEEECCHHH
MSRVPMGSDGGAWASDPATNYDVSFVPQGIGADLIATIEGFTRDDVDAYAARSQERAAAA
HHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
WSGGYFAKSVVPVKDQNGLLVLDHDEHMRPGTTAADLGKLKPAFEGLAALGGFDDVARIK
CCCCCHHCEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHH
YHYVEKINHVHTGGNSSGIVDGAALVLIGSEEAGKSQGLTPRARIVATATSGSEPLIMLT
HHHHHHHHHEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEE
GPTPATKKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPL
CCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCCC
GATGAMITGTMVDELERRGLKRALITLCVGGGMGVATIIERV
CCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TEAFIYEAVRTPRGKQRGGALNEIKPLNLVVGLIEEIRHRHPDLDENLISDVVLGVVSP
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
VGDQGGDIARTAVLAAGLPDTTGGVQLNRFCASGLEAINIGAQKVRSGWDDLVLAGGVES
CCCCCCCHHHHHHHHCCCCCCCCCEEHHHHHHCCHHEECCCHHHHHCCCCCEEEECCHHH
MSRVPMGSDGGAWASDPATNYDVSFVPQGIGADLIATIEGFTRDDVDAYAARSQERAAAA
HHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
WSGGYFAKSVVPVKDQNGLLVLDHDEHMRPGTTAADLGKLKPAFEGLAALGGFDDVARIK
CCCCCHHCEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHH
YHYVEKINHVHTGGNSSGIVDGAALVLIGSEEAGKSQGLTPRARIVATATSGSEPLIMLT
HHHHHHHHHEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEE
GPTPATKKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPL
CCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCCC
GATGAMITGTMVDELERRGLKRALITLCVGGGMGVATIIERV
CCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]