Click here to switch to the map view.

The map label for this gene is hsaA [H]

Identifier: 169627687

GI number: 169627687

Start: 584833

End: 586035

Strand: Direct

Name: hsaA [H]

Synonym: MAB_0584

Alternate gene names: 169627687

Gene position: 584833-586035 (Clockwise)

Preceding gene: 169627683

Following gene: 169627688

Centisome position: 11.54

GC content: 65.75

Gene sequence:

>1203_bases
GTGACGACGACCGAACAGCGGGAGCATTCTGACGAGGTTCTCTCGGTGCTTTCTCAGATAGACGACCTGCTGCCGACCCT
GCGCAAGCGTGCGCAGGAGACCGAGGACCTGCGGCGTCTGCCCGACGCCACGGTCGCCGAACTGCAGGAGATCGGCTTCT
TCAAGCTGCTGCAGCCGTCGCAGTGGGGTGGATACGAGACCGCGCCGACCACCTTCTACGAGGCGGTCCGCCGCCTGGGG
AGCGCGTGTGGCTCGACGGGCTGGGTTGCCTCGATCATCGGCGTGCACAACTGGCACTTAGCCCTGTTCGACCAGCAGGC
GCAGGAGGAAGTGTGGGGAGACGACACCGATGTGCGGGTGTCCTCCTCGTATGCCCCGATGGGTGCCGGTGTGGTGACCG
ACGCGGGCGACGGCTACCTCGTGAACGGTTCATGGAACTGGTCCTCGGGCTGCGACCACGCCACCTGGGCGTTCCTTGGC
GGTCCGGTCATCAAGGACGGTCGCCCCGTCGACTTCGGCAGCTTCCTGATCCCGCGCACCGAGTACCGCATCGATGACGT
GTGGAACGTGGTCGGCCTGCGCGGCACCGGTAGCAACACCGTGGTGGTGAAGGACGTGTTCGTGCCGAAGCATCGTTTCC
TGTCGTACAAGAAGATGAACGACCAGACCGCCGGTGGGTATCAGACCAACACCGCGCCGGTCTACAAGATGCCTTGGGGC
ACAATGCACCCCACTACCATCACCGCGCCGATCATGGGCATGGCCTACGGCGCGTACGACGCGCATGTCGAGGCGCAGGG
CAAGCGGGTACGTGCCGCTTACGCCGGCGAGAAGGCCAAGGACGACCCGTTCACCAAGGTGCGGGTGGCCGAGGCGGCCA
GTGACATCGACGCCGGGTGGCGTCAGCTGATCGGCAATGTGGGTGATGAATACGCGCTGATCGCGGCGGGCCAGGAGGTT
CCCTTCGAGCTGCGTGCCGCGGCGCGACGCGACCAGGTACGTGCCACCGGCCGGGCGATCGCTTCGATCGACCTGCTCTT
TGAGAACTCCGGCGCCACCGCATTGTCGAACGACGCTCCGGTGCAGCGTTTCTGGCGCGACGCCCACGCCGGCCGCGTGC
ACGCGGCCAATGACGCAGAGCGGGCTTACCAGATTTGGGGTAACCACGCCTTTGAGCTGCCCGCCACCGACACAATGGTT
TAG

Upstream 100 bases:

>100_bases
CTGCCACCGAGGGTGTGCAGCGAGTGTCGCGAACTACTAGCCCTAGTTTGTGCCGACTGATGCTAACGACAAGTGTCGGC
GGAACGCGGAAGGATGAACA

Downstream 100 bases:

>100_bases
GCCGGGTTTTAGGCCGGGTTTTAAGGAGAGCGGTACGACCATGAGCATCATCAAGGCACTCGGATACATGCGGATCCAGG
CAACAGACGTTGCGGCCTGG

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTTTEQREHSDEVLSVLSQIDDLLPTLRKRAQETEDLRRLPDATVAELQEIGFFKLLQPSQWGGYETAPTTFYEAVRRLG
SACGSTGWVASIIGVHNWHLALFDQQAQEEVWGDDTDVRVSSSYAPMGAGVVTDAGDGYLVNGSWNWSSGCDHATWAFLG
GPVIKDGRPVDFGSFLIPRTEYRIDDVWNVVGLRGTGSNTVVVKDVFVPKHRFLSYKKMNDQTAGGYQTNTAPVYKMPWG
TMHPTTITAPIMGMAYGAYDAHVEAQGKRVRAAYAGEKAKDDPFTKVRVAEAASDIDAGWRQLIGNVGDEYALIAAGQEV
PFELRAAARRDQVRATGRAIASIDLLFENSGATALSNDAPVQRFWRDAHAGRVHAANDAERAYQIWGNHAFELPATDTMV

Sequences:

>Translated_400_residues
MTTTEQREHSDEVLSVLSQIDDLLPTLRKRAQETEDLRRLPDATVAELQEIGFFKLLQPSQWGGYETAPTTFYEAVRRLG
SACGSTGWVASIIGVHNWHLALFDQQAQEEVWGDDTDVRVSSSYAPMGAGVVTDAGDGYLVNGSWNWSSGCDHATWAFLG
GPVIKDGRPVDFGSFLIPRTEYRIDDVWNVVGLRGTGSNTVVVKDVFVPKHRFLSYKKMNDQTAGGYQTNTAPVYKMPWG
TMHPTTITAPIMGMAYGAYDAHVEAQGKRVRAAYAGEKAKDDPFTKVRVAEAASDIDAGWRQLIGNVGDEYALIAAGQEV
PFELRAAARRDQVRATGRAIASIDLLFENSGATALSNDAPVQRFWRDAHAGRVHAANDAERAYQIWGNHAFELPATDTMV
>Mature_399_residues
TTTEQREHSDEVLSVLSQIDDLLPTLRKRAQETEDLRRLPDATVAELQEIGFFKLLQPSQWGGYETAPTTFYEAVRRLGS
ACGSTGWVASIIGVHNWHLALFDQQAQEEVWGDDTDVRVSSSYAPMGAGVVTDAGDGYLVNGSWNWSSGCDHATWAFLGG
PVIKDGRPVDFGSFLIPRTEYRIDDVWNVVGLRGTGSNTVVVKDVFVPKHRFLSYKKMNDQTAGGYQTNTAPVYKMPWGT
MHPTTITAPIMGMAYGAYDAHVEAQGKRVRAAYAGEKAKDDPFTKVRVAEAASDIDAGWRQLIGNVGDEYALIAAGQEVP
FELRAAARRDQVRATGRAIASIDLLFENSGATALSNDAPVQRFWRDAHAGRVHAANDAERAYQIWGNHAFELPATDTMV

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43930; Mature: 43799

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTEQREHSDEVLSVLSQIDDLLPTLRKRAQETEDLRRLPDATVAELQEIGFFKLLQPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCC
QWGGYETAPTTFYEAVRRLGSACGSTGWVASIIGVHNWHLALFDQQAQEEVWGDDTDVRV
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEE
SSSYAPMGAGVVTDAGDGYLVNGSWNWSSGCDHATWAFLGGPVIKDGRPVDFGSFLIPRT
ECCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEECCCC
EYRIDDVWNVVGLRGTGSNTVVVKDVFVPKHRFLSYKKMNDQTAGGYQTNTAPVYKMPWG
CCCHHHHHHEEEECCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCC
TMHPTTITAPIMGMAYGAYDAHVEAQGKRVRAAYAGEKAKDDPFTKVRVAEAASDIDAGW
CCCCCCHHHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHH
RQLIGNVGDEYALIAAGQEVPFELRAAARRDQVRATGRAIASIDLLFENSGATALSNDAP
HHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCH
VQRFWRDAHAGRVHAANDAERAYQIWGNHAFELPATDTMV
HHHHHHHHCCCEEECCCCHHHHHHHHCCCEEECCCCCCCC
>Mature Secondary Structure 
TTTEQREHSDEVLSVLSQIDDLLPTLRKRAQETEDLRRLPDATVAELQEIGFFKLLQPS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCC
QWGGYETAPTTFYEAVRRLGSACGSTGWVASIIGVHNWHLALFDQQAQEEVWGDDTDVRV
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEE
SSSYAPMGAGVVTDAGDGYLVNGSWNWSSGCDHATWAFLGGPVIKDGRPVDFGSFLIPRT
ECCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEECCCC
EYRIDDVWNVVGLRGTGSNTVVVKDVFVPKHRFLSYKKMNDQTAGGYQTNTAPVYKMPWG
CCCHHHHHHEEEECCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCC
TMHPTTITAPIMGMAYGAYDAHVEAQGKRVRAAYAGEKAKDDPFTKVRVAEAASDIDAGW
CCCCCCHHHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHH
RQLIGNVGDEYALIAAGQEVPFELRAAARRDQVRATGRAIASIDLLFENSGATALSNDAP
HHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCH
VQRFWRDAHAGRVHAANDAERAYQIWGNHAFELPATDTMV
HHHHHHHHCCCEEECCCCHHHHHHHHCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]