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The map label for this gene is hsaC [H]

Identifier: 169627688

GI number: 169627688

Start: 586076

End: 586978

Strand: Direct

Name: hsaC [H]

Synonym: MAB_0585

Alternate gene names: 169627688

Gene position: 586076-586978 (Clockwise)

Preceding gene: 169627687

Following gene: 169627689

Centisome position: 11.57

GC content: 61.57

Gene sequence:

>903_bases
ATGAGCATCATCAAGGCACTCGGATACATGCGGATCCAGGCAACAGACGTTGCGGCCTGGCGAGAGTTCGGAACCAAGGT
GCTTGGCATGATGGAGGGCACCGGCGACGACCCCGCGGCGCTCTACCTGCGGATGGATGATTTCGCGGCTCGCCTGGTGA
TCGTGCCGGGTGAGAGTGATCGGCTGCTGGCCTCCGGTTGGGAGGTCGCCGATGCGCCCGCACTACAGGCCGTGCGGGAA
CGTCTGGCCAAGGCCGGGGTTGAGTATGCCGAGGGCGACAAGGCGGAGGTCTCAGATCGCAAGGTCGAGGCCTTCATCCA
ATTCAGCGATCCGTCCGGGAATACGCTGGAGGTGTTCCACGGCGCCCAGTACATGGGACGGCGGTTTGTCAGCCCGTACG
GCCACAAGTTCGTCACCGCCGAACAAGGACTTGGGCATGTGGTGCTCACGTGTACTGATGACGTTGCGGCACAAGAGTTT
TACCAGGATGTACTCGGTTTCCAGCTGCGTGACTCGATGAAGCTGCCTCCTCAGCTGGTCGGCCGGCCGGCCGACGGTGA
TCCGGTGTGGCTGCGCTTCTACGGATGCAACCCGCGTCATCACGCGTTGGCGTTCATGCCGATGCCGAATCCCACCGGAA
TTGTGCACTTGATGGTCGAGGTGGAGAACTCCGATGATGTCGGGCTCTGCCTGGACCGCGCCAACCGGCGGAAGGTCAAG
ATGTCGGCAACGTTGGGCCGGCACATCAATGACAAGATGCTGTCCTTCTACATGAAGACTCCGGGTGGCTTCGACATGGA
ATTCGGCTGCGAAGGCATGGAAGTCGATGACGAGAGCTGGGTCGCGCGGGAGAGCGTCGGCGTCAGCTTGTGGGGTCACG
ACTTCAGCGTCGGTTTCAAGTAG

Upstream 100 bases:

>100_bases
GCTTACCAGATTTGGGGTAACCACGCCTTTGAGCTGCCCGCCACCGACACAATGGTTTAGGCCGGGTTTTAGGCCGGGTT
TTAAGGAGAGCGGTACGACC

Downstream 100 bases:

>100_bases
AGGTTCGCGCCGATATGTCTACACCGGAGATTGATCCTCGTACCTTCCGGAATGTACTGGGGCAATTCTGCACCGGTATC
ACCATCATCACCACGACGCA

Product: 2,3-dihydroxybiphenyl 1,2-dioxygenase

Products: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSIIKALGYMRIQATDVAAWREFGTKVLGMMEGTGDDPAALYLRMDDFAARLVIVPGESDRLLASGWEVADAPALQAVRE
RLAKAGVEYAEGDKAEVSDRKVEAFIQFSDPSGNTLEVFHGAQYMGRRFVSPYGHKFVTAEQGLGHVVLTCTDDVAAQEF
YQDVLGFQLRDSMKLPPQLVGRPADGDPVWLRFYGCNPRHHALAFMPMPNPTGIVHLMVEVENSDDVGLCLDRANRRKVK
MSATLGRHINDKMLSFYMKTPGGFDMEFGCEGMEVDDESWVARESVGVSLWGHDFSVGFK

Sequences:

>Translated_300_residues
MSIIKALGYMRIQATDVAAWREFGTKVLGMMEGTGDDPAALYLRMDDFAARLVIVPGESDRLLASGWEVADAPALQAVRE
RLAKAGVEYAEGDKAEVSDRKVEAFIQFSDPSGNTLEVFHGAQYMGRRFVSPYGHKFVTAEQGLGHVVLTCTDDVAAQEF
YQDVLGFQLRDSMKLPPQLVGRPADGDPVWLRFYGCNPRHHALAFMPMPNPTGIVHLMVEVENSDDVGLCLDRANRRKVK
MSATLGRHINDKMLSFYMKTPGGFDMEFGCEGMEVDDESWVARESVGVSLWGHDFSVGFK
>Mature_299_residues
SIIKALGYMRIQATDVAAWREFGTKVLGMMEGTGDDPAALYLRMDDFAARLVIVPGESDRLLASGWEVADAPALQAVRER
LAKAGVEYAEGDKAEVSDRKVEAFIQFSDPSGNTLEVFHGAQYMGRRFVSPYGHKFVTAEQGLGHVVLTCTDDVAAQEFY
QDVLGFQLRDSMKLPPQLVGRPADGDPVWLRFYGCNPRHHALAFMPMPNPTGIVHLMVEVENSDDVGLCLDRANRRKVKM
SATLGRHINDKMLSFYMKTPGGFDMEFGCEGMEVDDESWVARESVGVSLWGHDFSVGFK

Specific function: Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4- oic acid (4,9-DSHA). Also involved in biphenyl and polychlorinated biphenyls

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the extradiol ring-cleavage dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR000486 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.39

Molecular weight: Translated: 33251; Mature: 33120

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00082 EXTRADIOL_DIOXYGENAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIKALGYMRIQATDVAAWREFGTKVLGMMEGTGDDPAALYLRMDDFAARLVIVPGESD
CCHHHHHCEEEEEEHHHHHHHHHHHHEEEHCCCCCCCCEEEEEEEECCEEEEEEEECCCC
RLLASGWEVADAPALQAVRERLAKAGVEYAEGDKAEVSDRKVEAFIQFSDPSGNTLEVFH
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEE
GAQYMGRRFVSPYGHKFVTAEQGLGHVVLTCTDDVAAQEFYQDVLGFQLRDSMKLPPQLV
CHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHCEEECCCCCCCHHHC
GRPADGDPVWLRFYGCNPRHHALAFMPMPNPTGIVHLMVEVENSDDVGLCLDRANRRKVK
CCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCEEEECCCCCCEEE
MSATLGRHINDKMLSFYMKTPGGFDMEFGCEGMEVDDESWVARESVGVSLWGHDFSVGFK
EEHHHCCCCCHHEEEEEECCCCCCCCEECCCCCCCCCCHHHHHHHCCEEEECCEEECCCC
>Mature Secondary Structure 
SIIKALGYMRIQATDVAAWREFGTKVLGMMEGTGDDPAALYLRMDDFAARLVIVPGESD
CHHHHHCEEEEEEHHHHHHHHHHHHEEEHCCCCCCCCEEEEEEEECCEEEEEEEECCCC
RLLASGWEVADAPALQAVRERLAKAGVEYAEGDKAEVSDRKVEAFIQFSDPSGNTLEVFH
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEE
GAQYMGRRFVSPYGHKFVTAEQGLGHVVLTCTDDVAAQEFYQDVLGFQLRDSMKLPPQLV
CHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHCEEECCCCCCCHHHC
GRPADGDPVWLRFYGCNPRHHALAFMPMPNPTGIVHLMVEVENSDDVGLCLDRANRRKVK
CCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCEEEECCCCCCEEE
MSATLGRHINDKMLSFYMKTPGGFDMEFGCEGMEVDDESWVARESVGVSLWGHDFSVGFK
EEHHHCCCCCHHEEEEEECCCCCCCCEECCCCCCCCCCHHHHHHHCCEEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: biphenyl-2,3-diol; O2

Specific reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA