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The map label for this gene is folP1 [H]

Identifier: 169627639

GI number: 169627639

Start: 537152

End: 538204

Strand: Direct

Name: folP1 [H]

Synonym: MAB_0535

Alternate gene names: 169627639

Gene position: 537152-538204 (Clockwise)

Preceding gene: 169627638

Following gene: 169627640

Centisome position: 10.6

GC content: 64.86

Gene sequence:

>1053_bases
ATGATCGCTGGCGTGACGGAAACTCCCGCACTGACCCACATCCTGGGAGTCGTCAATGTCACCGACGACTCCTTCTCTGA
CGGTGGACGATTCGTCCGTCAATCGGACGCGGTAGCGCACGGCCTGGCGCTTGCGTCCGCGGGCGCGGACATCATCGATG
TCGGTGGCCAGTCGACTCGGCCTGGTGCGGCGCCGATCAGGCAGAAGATCGAGATGCAACGTGTCATCCCGGTGATCAAA
GAGCTTGCCAGTCATGGCATCAACATCAGTGTGGACACCATGCGTGCGGAGGTCGCGGCCGCCGCGATCGATGCCGGCGC
GAACATGGTCAACGATGTCTCGGGCGGCAGGTCCGACCCGGAGATGGCGCAGCTGATCGCGCAACGAGGTGTTCCTTGGA
TTCTGATGCATTGGCGTTCAAAGGATTTCATCCACACACCGGCTACCCGAAACTATCGCGATGTGGTCGCCGACGTTTCT
CGTGAGCTGATGGAGTCGGTGGCGGTGGCGGTCAACGCGGGTGTCTCACCGGACAAGCTCATCCTCGACCCGGGCCTGGG
CTTCGCCAAAACCGCACACCACAACTGGCTGCTGCTGCAAGCGATCCCGGACCTGCAAGAACTGGGCTACCCGATCTTGA
TCGGTGCGTCCCGCAAACGGTTCCTGGGCTCGCTGCTTACCGACCTCAAGGGTGTGGAGCGGCCGCCCGACGGCCGTGAA
ACCGCGACGGCCGTCATCACCGCGCTGGGTGCGCTGCACGAGGTGTGGGGGGTACGTGTCCATGACGTGACGGCCTCGAT
GGACGCGTTGAAGGTGGTGCGCGCCTGGGAGACCGGCGGTGCGGAAACCGTCGAAGAGGGTGAAGAAGAAGCCCAAGAGG
CAGCCGCCCCGGAACCGCCGCCCGCGCCGGAATCCCCGCCCGTGACCATCGCGCAGGATGAGGTCACCACCGAGGTGACG
GTGCGCACCGCACGGCCCGAGCCCAGTAAGACCGCGGGTGGCAGGTGGCGTCGGGAGGTGGCGCAACGCGGCGCCAAAGG
TGAACCGAAATGA

Upstream 100 bases:

>100_bases
TACGCAAGCCCGGTGCGACTACCACGACCTCCGCCGTACGGGGTCAGTTCAAACGTGACGCCGCTTCCCGGGCCGAGGTT
CTTGACTTGATGATGAGGAC

Downstream 100 bases:

>100_bases
CCGACCGTATCGAGCTGCGTGGGTTGAAAGTATTTGGCTACCACGGAGTTTTTGAGCATGAGCGTCGTGATGGACAGGAG
TTTTCGGTCGACATCACTGT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIAGVTETPALTHILGVVNVTDDSFSDGGRFVRQSDAVAHGLALASAGADIIDVGGQSTRPGAAPIRQKIEMQRVIPVIK
ELASHGINISVDTMRAEVAAAAIDAGANMVNDVSGGRSDPEMAQLIAQRGVPWILMHWRSKDFIHTPATRNYRDVVADVS
RELMESVAVAVNAGVSPDKLILDPGLGFAKTAHHNWLLLQAIPDLQELGYPILIGASRKRFLGSLLTDLKGVERPPDGRE
TATAVITALGALHEVWGVRVHDVTASMDALKVVRAWETGGAETVEEGEEEAQEAAAPEPPPAPESPPVTIAQDEVTTEVT
VRTARPEPSKTAGGRWRREVAQRGAKGEPK

Sequences:

>Translated_350_residues
MIAGVTETPALTHILGVVNVTDDSFSDGGRFVRQSDAVAHGLALASAGADIIDVGGQSTRPGAAPIRQKIEMQRVIPVIK
ELASHGINISVDTMRAEVAAAAIDAGANMVNDVSGGRSDPEMAQLIAQRGVPWILMHWRSKDFIHTPATRNYRDVVADVS
RELMESVAVAVNAGVSPDKLILDPGLGFAKTAHHNWLLLQAIPDLQELGYPILIGASRKRFLGSLLTDLKGVERPPDGRE
TATAVITALGALHEVWGVRVHDVTASMDALKVVRAWETGGAETVEEGEEEAQEAAAPEPPPAPESPPVTIAQDEVTTEVT
VRTARPEPSKTAGGRWRREVAQRGAKGEPK
>Mature_350_residues
MIAGVTETPALTHILGVVNVTDDSFSDGGRFVRQSDAVAHGLALASAGADIIDVGGQSTRPGAAPIRQKIEMQRVIPVIK
ELASHGINISVDTMRAEVAAAAIDAGANMVNDVSGGRSDPEMAQLIAQRGVPWILMHWRSKDFIHTPATRNYRDVVADVS
RELMESVAVAVNAGVSPDKLILDPGLGFAKTAHHNWLLLQAIPDLQELGYPILIGASRKRFLGSLLTDLKGVERPPDGRE
TATAVITALGALHEVWGVRVHDVTASMDALKVVRAWETGGAETVEEGEEEAQEAAAPEPPPAPESPPVTIAQDEVTTEVT
VRTARPEPSKTAGGRWRREVAQRGAKGEPK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=264, Percent_Identity=39.3939393939394, Blast_Score=185, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324073, Length=331, Percent_Identity=29.9093655589124, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 37206; Mature: 37206

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAGVTETPALTHILGVVNVTDDSFSDGGRFVRQSDAVAHGLALASAGADIIDVGGQSTR
CCCCCCCCHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PGAAPIRQKIEMQRVIPVIKELASHGINISVDTMRAEVAAAAIDAGANMVNDVSGGRSDP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCHHHHHCCCCCCCH
EMAQLIAQRGVPWILMHWRSKDFIHTPATRNYRDVVADVSRELMESVAVAVNAGVSPDKL
HHHHHHHHCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
ILDPGLGFAKTAHHNWLLLQAIPDLQELGYPILIGASRKRFLGSLLTDLKGVERPPDGRE
EECCCCCCHHHCCCCEEEEEECCCHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHH
TATAVITALGALHEVWGVRVHDVTASMDALKVVRAWETGGAETVEEGEEEAQEAAAPEPP
HHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PAPESPPVTIAQDEVTTEVTVRTARPEPSKTAGGRWRREVAQRGAKGEPK
CCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIAGVTETPALTHILGVVNVTDDSFSDGGRFVRQSDAVAHGLALASAGADIIDVGGQSTR
CCCCCCCCHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PGAAPIRQKIEMQRVIPVIKELASHGINISVDTMRAEVAAAAIDAGANMVNDVSGGRSDP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCHHHHHCCCCCCCH
EMAQLIAQRGVPWILMHWRSKDFIHTPATRNYRDVVADVSRELMESVAVAVNAGVSPDKL
HHHHHHHHCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
ILDPGLGFAKTAHHNWLLLQAIPDLQELGYPILIGASRKRFLGSLLTDLKGVERPPDGRE
EECCCCCCHHHCCCCEEEEEECCCHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHH
TATAVITALGALHEVWGVRVHDVTASMDALKVVRAWETGGAETVEEGEEEAQEAAAPEPP
HHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PAPESPPVTIAQDEVTTEVTVRTARPEPSKTAGGRWRREVAQRGAKGEPK
CCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]