Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 169627286

GI number: 169627286

Start: 183845

End: 185398

Strand: Direct

Name: pccB [H]

Synonym: MAB_0181

Alternate gene names: 169627286

Gene position: 183845-185398 (Clockwise)

Preceding gene: 169627285

Following gene: 169627292

Centisome position: 3.63

GC content: 64.03

Gene sequence:

>1554_bases
GTGCCACCACACACAACTGCGGAGAAGCTCGCCGACCTGCGTGAGCGGATTGCGCTCACCCGCGAGCCGGGTGATGCCAA
GGCCATCGCCAGGCGCGACAAGAAGGGCATCCCGAGTGCCCGCGCCCGCATCGACGCGCTGCTCGACAAGGGCAGTTTCT
TGGAACTCGACGCGTTCGCCCGCACTCCCGGTGATGCCAACGCGCCGTACACCGATGGTGTGGTCACCGGTCTGGGGCGC
ATCGACGGCCGCCCCGTCGCGGTGTTTTCACACGACCAGACCGTGTACCAGGGCAGCGTCGGTGAGATGTTCGGCCGCAA
GGTTGCCAAGCTCATGGAATGGGCGGCGACCAACGGATGCCCGGTGATCGGCATCAACGATTCGGCGGGCGCCCGCATCC
AGGACACCGCCACGTCGTTGGCCTGGTACGCCGAATTGGGCCGCCGTCACGAGCTGCTGCGCGGCACGGTGCCCGAGATC
TCGATCATTCTGGGCAAGTGCGCCGGTGGTGCCGTGTACTCACCGATCCAGACCGATCTGTTGGTGGCGGTCCGCGACCA
GGGCTACATGTTCATCACCGGGCCTGACGTCATCAAGGACGTCACCGGCGAGGACGTGAGCTTCGACGAGCTCGGTGGGG
CCGACGTACAGGCTCAGCGCGGCAACATCCACAAGGTCGTCGAGGACGAGGCCGCCGCGTTCCAGTACGTGCGGGACTAC
CTGAGCTTCCTGCCCTCCAACACCTTCGATTACCCGCCGATCGTCAACCCGGGCCTGGAGCCGGAAATCACCGAGGACGA
TCTGTATCTCGACACGTTCATCCCCGATAGCGACAACCAGGGTTACGACATGATGGAGATCCTGCTGAGGATCTTCGATG
ACGGCGACATCTTCGAGATCTCCGAGCAGCGTGGTCCCGCGATGATCACGGCGTTCGCGCGGGTCGACGGGCACCCGGTG
GGAGTGATCGCCAACCAGCCGCTGCAGATGGCGGGCGCTGTCGACACCGATGCCTCCGACAAGGCCGCCAGCTTCATCCG
TTTCTGCGACGCGTACAACCTGCCGCTGGTGTTCGTGGTCGACACGCCGGGCGCGCTACCCGGTGTGTCGGAGGAGAAGA
ACGGCATCATCAAGAAGGGTGGCCGTTTCTTCAACGCGGTGGTGGAAGCCGATGTGCCCAAGGTGACCATCATTACCCGC
AAGGCCTACGGCGGTGGGTATGCGGTGATGGGTTCCAAGCAGCTCTCGGCCGACCTGAACTATGTTTGGCCGACCGCACG
TATCGCGGTGATCGGTGCCGAGGGCGCCGCGCAGCTGCTGGTGAAGCGCTTCCCGGACCCGACGGCACCCGAGGTGCAGA
AGATCCGGGCGGACTTCATCGAGGGCTACAACAAGAATCTGGCGACGCCGTGGATCGCGGCCGAGCGCGGTTATATCGAT
GGCGTCATCGAGCCGCACCAGACCCGTCTATTGCTACGTAAGTCGCTGAAGCTGTTGCGGGACAAGCAGAAGCATGATCG
CATGCAGCGTAAGCACGGTCTGACCCCAATCTAA

Upstream 100 bases:

>100_bases
CGACGAACCGATCATCGCTAAGGTCGGTGCTCATATGAGTCAGGCGCTGCGGACCATCAACGCCCAACAGGCCCAGCAGG
CTTAGAAAGGTTCAGACACT

Downstream 100 bases:

>100_bases
GGATTCATCGCACGAAGGCCCCGTACGCACCGCGCGTCGGGGGCCTTCGTGTTCGGTGGAGATCAGTCGCGCAGGATCAG
GGCACGACTGCCGGCGTGCG

Product: propionyl-CoA carboxylase, beta subunit (PccB)

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MPPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSARARIDALLDKGSFLELDAFARTPGDANAPYTDGVVTGLGR
IDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGINDSAGARIQDTATSLAWYAELGRRHELLRGTVPEI
SIILGKCAGGAVYSPIQTDLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEAAAFQYVRDY
LSFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQGYDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHPV
GVIANQPLQMAGAVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVSEEKNGIIKKGGRFFNAVVEADVPKVTIITR
KAYGGGYAVMGSKQLSADLNYVWPTARIAVIGAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYID
GVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGLTPI

Sequences:

>Translated_517_residues
MPPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSARARIDALLDKGSFLELDAFARTPGDANAPYTDGVVTGLGR
IDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGINDSAGARIQDTATSLAWYAELGRRHELLRGTVPEI
SIILGKCAGGAVYSPIQTDLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEAAAFQYVRDY
LSFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQGYDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHPV
GVIANQPLQMAGAVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVSEEKNGIIKKGGRFFNAVVEADVPKVTIITR
KAYGGGYAVMGSKQLSADLNYVWPTARIAVIGAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYID
GVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGLTPI
>Mature_516_residues
PPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSARARIDALLDKGSFLELDAFARTPGDANAPYTDGVVTGLGRI
DGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGINDSAGARIQDTATSLAWYAELGRRHELLRGTVPEIS
IILGKCAGGAVYSPIQTDLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEAAAFQYVRDYL
SFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQGYDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHPVG
VIANQPLQMAGAVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVSEEKNGIIKKGGRFFNAVVEADVPKVTIITRK
AYGGGYAVMGSKQLSADLNYVWPTARIAVIGAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYIDG
VIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGLTPI

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=527, Percent_Identity=42.6944971537002, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI295821216, Length=547, Percent_Identity=41.1334552102377, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=29.5409181636727, Blast_Score=210, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI25147362, Length=527, Percent_Identity=41.5559772296015, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI25147359, Length=527, Percent_Identity=41.5559772296015, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17552936, Length=498, Percent_Identity=29.5180722891566, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=291, Percent_Identity=24.7422680412371, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586065, Length=521, Percent_Identity=31.0940499040307, Blast_Score=238, Evalue=9e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56386; Mature: 56255

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSARARIDALLDKGSFLELDAFA
CCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHH
RTPGDANAPYTDGVVTGLGRIDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGC
CCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCCC
PVIGINDSAGARIQDTATSLAWYAELGRRHELLRGTVPEISIILGKCAGGAVYSPIQTDL
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCE
LVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEAAAFQYVRDY
EEEEECCCEEEEECHHHHHHCCCCCCCHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
LSFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQGYDMMEILLRIFDDGDIFEI
HHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
SEQRGPAMITAFARVDGHPVGVIANQPLQMAGAVDTDASDKAASFIRFCDAYNLPLVFVV
CCCCCCEEEEEEECCCCCEEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
DTPGALPGVSEEKNGIIKKGGRFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLSADLN
ECCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHCCCCC
YVWPTARIAVIGAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYID
EECCCEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCC
GVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGLTPI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSARARIDALLDKGSFLELDAFA
CCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHH
RTPGDANAPYTDGVVTGLGRIDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGC
CCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCCC
PVIGINDSAGARIQDTATSLAWYAELGRRHELLRGTVPEISIILGKCAGGAVYSPIQTDL
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCE
LVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEAAAFQYVRDY
EEEEECCCEEEEECHHHHHHCCCCCCCHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
LSFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQGYDMMEILLRIFDDGDIFEI
HHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
SEQRGPAMITAFARVDGHPVGVIANQPLQMAGAVDTDASDKAASFIRFCDAYNLPLVFVV
CCCCCCEEEEEEECCCCCEEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
DTPGALPGVSEEKNGIIKKGGRFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLSADLN
ECCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHCCCCC
YVWPTARIAVIGAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYID
EECCCEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCC
GVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGLTPI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]