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The map label for this gene is fbpA [H]

Identifier: 169627282

GI number: 169627282

Start: 173985

End: 174962

Strand: Direct

Name: fbpA [H]

Synonym: MAB_0177

Alternate gene names: 169627282

Gene position: 173985-174962 (Clockwise)

Preceding gene: 169627281

Following gene: 169627283

Centisome position: 3.43

GC content: 63.91

Gene sequence:

>978_bases
ATGAAGCTCTTTTCACAATTGCGCGGTAAGACCGCGCGTCGACTTGCCACTGTGGCCGCAGCTGCGGCCGTTCTGCCTGG
ATTCATCGGTGTCGCCGGTGGTTCCGCGGTCGCCAACGCGTTCTCGCGCCCGGGTCTTCCGGTCGAGTACCTGCAGGTGC
CCTCGGCGGCCATGAACACCAGCATCAAGGTCCAGTTCCAGAACGGTGGCGCCAAGTCCGTCTACCTGCTGGACGGTCTG
CGTGCGCGCGATGACTTCAGCGGCTGGGACATCGAGACCACGGCGTTCGAGGACTACTACCAGTCCGGTATCTCCGTCGT
CATGCCCGTCGGCGGCCAGTCCAGCTGGTACACCGACTGGTACCAGCCGGCCAAGGGTAAGGATGGCGTCTTCACCTACA
AGTGGGAGACCTTCCTGACCCAGGAGCTGCCCGCCTTCCTGGCCAACCAGGGGCTGTCCAAGACCGGTAACGCGGTTGTC
GGTCTGTCGATGGGTGCCGCTTCTGCCCTGAACCTCGCGAACTACCACCCACAGCAGTTCATTTACGCCGGTGCGCTCTC
GGGCTTCCTGCACCCGGCCGACATGAAGGGCCAGATCGGTATGGCCATGGGCGACGCCGGTGGCTTCAACCCGCAGGACA
TGTGGGGCCCCGACAGCGACCCGGCCTGGGTTCGTAACGACCCGTTCCTGAACATCGACCGGACGGTGGCCAACGGCACT
CGCCTGTGGATCTACTGCGGTAGCGGTGACGCCACCGACCTGGACGCCACGCGTAACGGCTTCGAGAACTTCACCGGTGG
TTTCCTCGAGGGCATGGCCATCGGCTCGAACAAGCAGTACGTCGATGCCTACACCGCTGCCGGCGGCAAGAACGCCCATG
TGGAGTTCCCCCCGGGTGGTCTGCACAACTGGACCTACTGGGGCAACCAGCTCAAGGCCATGAAGTCCGACATGGTGGGC
TACCTGCAGAGCCACTAG

Upstream 100 bases:

>100_bases
TGATGTGGTTGACTACCTCGGGAACCCCAGGGGCGTCCATCGGGATGTCCATCGGCCTGACATGTGTAACGCCGATTGAA
GTAGACGGGATACTGAGGGA

Downstream 100 bases:

>100_bases
GCGCAAGAGCAATCTCGGGCGGCGGCGGCCACTCTGTCTCAGGACAGGTGGCCGCCGCCGTCGTCATTTCGGGGGGGGAC
TGGCCGATGGGCCACAATCA

Product: antigen 85-A/B/C precursor

Products: NA

Alternate protein names: Antigen 85 complex A; 85A; Ag85A; Fibronectin-binding protein A; Mycolyl transferase 85A [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKLFSQLRGKTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLPVEYLQVPSAAMNTSIKVQFQNGGAKSVYLLDGL
RARDDFSGWDIETTAFEDYYQSGISVVMPVGGQSSWYTDWYQPAKGKDGVFTYKWETFLTQELPAFLANQGLSKTGNAVV
GLSMGAASALNLANYHPQQFIYAGALSGFLHPADMKGQIGMAMGDAGGFNPQDMWGPDSDPAWVRNDPFLNIDRTVANGT
RLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQYVDAYTAAGGKNAHVEFPPGGLHNWTYWGNQLKAMKSDMVG
YLQSH

Sequences:

>Translated_325_residues
MKLFSQLRGKTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLPVEYLQVPSAAMNTSIKVQFQNGGAKSVYLLDGL
RARDDFSGWDIETTAFEDYYQSGISVVMPVGGQSSWYTDWYQPAKGKDGVFTYKWETFLTQELPAFLANQGLSKTGNAVV
GLSMGAASALNLANYHPQQFIYAGALSGFLHPADMKGQIGMAMGDAGGFNPQDMWGPDSDPAWVRNDPFLNIDRTVANGT
RLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQYVDAYTAAGGKNAHVEFPPGGLHNWTYWGNQLKAMKSDMVG
YLQSH
>Mature_325_residues
MKLFSQLRGKTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLPVEYLQVPSAAMNTSIKVQFQNGGAKSVYLLDGL
RARDDFSGWDIETTAFEDYYQSGISVVMPVGGQSSWYTDWYQPAKGKDGVFTYKWETFLTQELPAFLANQGLSKTGNAVV
GLSMGAASALNLANYHPQQFIYAGALSGFLHPADMKGQIGMAMGDAGGFNPQDMWGPDSDPAWVRNDPFLNIDRTVANGT
RLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQYVDAYTAAGGKNAHVEFPPGGLHNWTYWGNQLKAMKSDMVG
YLQSH

Specific function: Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintain

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial A85 antigen family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 34909; Mature: 34909

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFSQLRGKTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLPVEYLQVPSAAMNT
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHCCCHHHHCC
SIKVQFQNGGAKSVYLLDGLRARDDFSGWDIETTAFEDYYQSGISVVMPVGGQSSWYTDW
EEEEEECCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCC
YQPAKGKDGVFTYKWETFLTQELPAFLANQGLSKTGNAVVGLSMGAASALNLANYHPQQF
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHCCCHHHH
IYAGALSGFLHPADMKGQIGMAMGDAGGFNPQDMWGPDSDPAWVRNDPFLNIDRTVANGT
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCCEEECCEECCCC
RLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQYVDAYTAAGGKNAHVEFPPGG
EEEEEECCCCCCCCHHHHCCHHHHCCCHHHCEEECCCCCEEEEEECCCCCCCEEECCCCC
LHNWTYWGNQLKAMKSDMVGYLQSH
CCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLFSQLRGKTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLPVEYLQVPSAAMNT
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHCCCHHHHCC
SIKVQFQNGGAKSVYLLDGLRARDDFSGWDIETTAFEDYYQSGISVVMPVGGQSSWYTDW
EEEEEECCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCC
YQPAKGKDGVFTYKWETFLTQELPAFLANQGLSKTGNAVVGLSMGAASALNLANYHPQQF
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHCCCHHHH
IYAGALSGFLHPADMKGQIGMAMGDAGGFNPQDMWGPDSDPAWVRNDPFLNIDRTVANGT
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEECCCCCEEECCEECCCC
RLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQYVDAYTAAGGKNAHVEFPPGG
EEEEEECCCCCCCCHHHHCCHHHHCCCHHHCEEECCCCCEEEEEECCCCCCCEEECCCCC
LHNWTYWGNQLKAMKSDMVGYLQSH
CCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7725062; 12788972 [H]