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The map label for this gene is fbpA [H]

Identifier: 169627281

GI number: 169627281

Start: 172726

End: 173727

Strand: Direct

Name: fbpA [H]

Synonym: MAB_0176

Alternate gene names: 169627281

Gene position: 172726-173727 (Clockwise)

Preceding gene: 169627280

Following gene: 169627282

Centisome position: 3.41

GC content: 63.17

Gene sequence:

>1002_bases
ATGAAGCTCTTTTCGAAGATGCGTGGTGCCTTGGCGCGTCAGTCGGCGCGCCGGATTGCGGTAGCGGCCACGGCCGTCGC
AGTCTTGCCCGGTGTGGCGGGCATCGTCGGCGGTACGGCGCTGACTCCGGTTGCGGGCGCCTTCTCACGTCCCGGGCTTC
CGGTCGAGTACCTGCAGGTGCCGTCGGCGTCGATGGGCCGTGAGATCAAGGTTCAGTTCCAGCCCGGTGGCGCCAAGGCC
GTCTACCTGCTGGACGGTCTGCGTGCGCGCGATGACTTCAGCGGTTGGGACATCGAGACCACGGCGTTCGAGGACTACTA
CCAGTCCGGTATCTCCATGGTCATGCCCGTCGGTGGTCAGTCCAGCTTCTACACGGACTGGTACAACCCGGCCAAGGGCA
AGGACGGCGTGTGGACCTACAAGTGGGAAACCTTCACCACTCAGGAACTCCCGGCGTATCTTGCTGCGAACAAGGGTATT
TCGCAGACCGGTAATGCGGTCGTCGGTCTGTCGATGGGTGCCTCGGCGGCGCTGACCCTGTCGATCTACCACCCGCAGCT
GTTCGTCTACGCCGGTGCGCTCTCGGGCTTCCTGAACCCGTCGGACATGAAGTTCCAGATCGGCCTCGCCATGGGTGACG
CCGGTGGCTTCAGCGCCTCCGACATGTGGGGCCCGGACAGCGATCCGGCCTGGCAGCGCAACGACCCGTTCCTGAACATC
CAGAAGATCATCGACAACGGCACTCGCCTGTGGATCTACTGCGGTACCGGTGATTCCACCGATCTGGACGCCACGCGTAA
CGGCTTCGAGAACTTCACCGGTGGTTTCCTCGAGGGCATGGCCATCGGTTCGAACAAGAAGTTCGTCGAGGCGTACACCG
CGGCCGGTGGCAAGAACGCACACATCGAGTTTCCTCCGGGCGGTATCCACAACTGGACCTACTGGGGTCAGCAGTTGCGG
GCCATGAAGCCTGACATGGTCGCGTACCTGCAGAGCCACTAG

Upstream 100 bases:

>100_bases
TGATTGCCACGCTTAACGGCTAAGATCCCGGGGCACCTTGGGAAGGTCCGCAGGCGCACGTAGTGGGAAATCGATTGAGA
CAGATGGGAAAACGAAGTAA

Downstream 100 bases:

>100_bases
GCATAAGCAGTACAAAGAGCGGTGGTCACTCTCCGTGGAGGGGGGTGGCCACCGCTCTTTTTGTCTTCGCCGGGTTGTGT
CTCGGTAAAACATCGGTCCG

Product: antigen 85-A precursor

Products: NA

Alternate protein names: Antigen 85 complex A; 85A; Ag85A; Fibronectin-binding protein A; Mycolyl transferase 85A [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSRPGLPVEYLQVPSASMGREIKVQFQPGGAKA
VYLLDGLRARDDFSGWDIETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKDGVWTYKWETFTTQELPAYLAANKGI
SQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSGFLNPSDMKFQIGLAMGDAGGFSASDMWGPDSDPAWQRNDPFLNI
QKIIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAYTAAGGKNAHIEFPPGGIHNWTYWGQQLR
AMKPDMVAYLQSH

Sequences:

>Translated_333_residues
MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSRPGLPVEYLQVPSASMGREIKVQFQPGGAKA
VYLLDGLRARDDFSGWDIETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKDGVWTYKWETFTTQELPAYLAANKGI
SQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSGFLNPSDMKFQIGLAMGDAGGFSASDMWGPDSDPAWQRNDPFLNI
QKIIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAYTAAGGKNAHIEFPPGGIHNWTYWGQQLR
AMKPDMVAYLQSH
>Mature_333_residues
MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSRPGLPVEYLQVPSASMGREIKVQFQPGGAKA
VYLLDGLRARDDFSGWDIETTAFEDYYQSGISMVMPVGGQSSFYTDWYNPAKGKDGVWTYKWETFTTQELPAYLAANKGI
SQTGNAVVGLSMGASAALTLSIYHPQLFVYAGALSGFLNPSDMKFQIGLAMGDAGGFSASDMWGPDSDPAWQRNDPFLNI
QKIIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAYTAAGGKNAHIEFPPGGIHNWTYWGQQLR
AMKPDMVAYLQSH

Specific function: Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintain

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial A85 antigen family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 35826; Mature: 35826

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSRPGLPVEYLQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHCCCCCCCCHHEEC
PSASMGREIKVQFQPGGAKAVYLLDGLRARDDFSGWDIETTAFEDYYQSGISMVMPVGGQ
CCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEECCCC
SSFYTDWYNPAKGKDGVWTYKWETFTTQELPAYLAANKGISQTGNAVVGLSMGASAALTL
CCEEECCCCCCCCCCCEEEEEEEEECHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEE
SIYHPQLFVYAGALSGFLNPSDMKFQIGLAMGDAGGFSASDMWGPDSDPAWQRNDPFLNI
EEECCEEEEEEHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEH
QKIIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAYTAAGGKNA
HHHHCCCCEEEEEECCCCCCCCCHHHCCHHHCCCCHHEEEEECCCCCEEEEEECCCCCCC
HIEFPPGGIHNWTYWGQQLRAMKPDMVAYLQSH
EEECCCCCCCCHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MKLFSKMRGALARQSARRIAVAATAVAVLPGVAGIVGGTALTPVAGAFSRPGLPVEYLQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHCCCCCCCCHHEEC
PSASMGREIKVQFQPGGAKAVYLLDGLRARDDFSGWDIETTAFEDYYQSGISMVMPVGGQ
CCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEECCCC
SSFYTDWYNPAKGKDGVWTYKWETFTTQELPAYLAANKGISQTGNAVVGLSMGASAALTL
CCEEECCCCCCCCCCCEEEEEEEEECHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEE
SIYHPQLFVYAGALSGFLNPSDMKFQIGLAMGDAGGFSASDMWGPDSDPAWQRNDPFLNI
EEECCEEEEEEHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEH
QKIIDNGTRLWIYCGTGDSTDLDATRNGFENFTGGFLEGMAIGSNKKFVEAYTAAGGKNA
HHHHCCCCEEEEEECCCCCCCCCHHHCCHHHCCCCHHEEEEECCCCCEEEEEECCCCCCC
HIEFPPGGIHNWTYWGQQLRAMKPDMVAYLQSH
EEECCCCCCCCHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7725062; 12788972 [H]