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The map label for this gene is msrA1 [H]

Identifier: 169627225

GI number: 169627225

Start: 119060

End: 119806

Strand: Direct

Name: msrA1 [H]

Synonym: MAB_0120

Alternate gene names: 169627225

Gene position: 119060-119806 (Clockwise)

Preceding gene: 169627221

Following gene: 169627226

Centisome position: 2.35

GC content: 66.27

Gene sequence:

>747_bases
ATGGCTTCTTGGGTGGATAACGTTCGCGATCAGATCTTGGGGCGAATCGAAGATGGGCTCAAACCGGGAAAGTCGGCAAT
CGTCGCCGAGGATGCGGCATTGCCTGGGCGCGCGACACCGATTCGGGTGTCCGGCACGCACTTCGTCAACGGCCACACGA
CAGTGCCGCCGTTCCCGGACGGATGTGAGCTCGCGGTGTTCGGGGAGGGGTGCTTCTGGGGCGCCGAACGCGGCTTCTGG
AAGCTTCCCGGCGTCTACTCCACCGCAGTGGGCTACGCCGGGGGATACACGCCCAACCCCACGTATGAAGAGGTGTGCTC
GGGGCGGACCGGCCACGCGGAGGTGGTGCTGGTGGTGTTCGACCCTCGAGAGGTGACCTACGGGCAGCTGCTGGTGCAGT
TCTGGGAGAGCCACGACCCGACTCAGGGGATGCGCCAAGGGAACGACCGCGGAACCCAGTACCGGTCCGTGATCTATACG
ACCAGTGAGGGGCAGGCAGTCCAGGCCGCCGAGAGCGCCGCACGGTACGAGGCTGCCCTGGCCGATGCCGGATATGGGGC
GATCACCACCGAGATCGCGCCATTGAACGGGCCCGTCGGACACGCGTCGCGGACGTTTTTCTACGCCGAGGAGTATCACC
AGCAGTACCTGGCCAAGAACCCGAATGGGTACTGCGGGCTCGGCGGGACCTCGGTTTCCTGCCCCATTGGGTTGGACGTG
CCGCCCGGCGGCCCGGCCGAGGCGTGA

Upstream 100 bases:

>100_bases
TAGCTCCAAATCGCGGTGCGCGAAAATTCACCCAGCGTGTACCTGGAAACCCCAGCTCGACCAGCAAATTGGGCACCGCG
GGCGGCGTACCATCGAGTCC

Downstream 100 bases:

>100_bases
GCTATCCCACGGGTGTGGCAGTGAATTCGCTAACTCTGCACACGCAGTGCTACGGTTCCCCGTCGCGAGCGCCGCTGGGC
CGCATCGTGGAGTCCTGGCC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MASWVDNVRDQILGRIEDGLKPGKSAIVAEDAALPGRATPIRVSGTHFVNGHTTVPPFPDGCELAVFGEGCFWGAERGFW
KLPGVYSTAVGYAGGYTPNPTYEEVCSGRTGHAEVVLVVFDPREVTYGQLLVQFWESHDPTQGMRQGNDRGTQYRSVIYT
TSEGQAVQAAESAARYEAALADAGYGAITTEIAPLNGPVGHASRTFFYAEEYHQQYLAKNPNGYCGLGGTSVSCPIGLDV
PPGGPAEA

Sequences:

>Translated_248_residues
MASWVDNVRDQILGRIEDGLKPGKSAIVAEDAALPGRATPIRVSGTHFVNGHTTVPPFPDGCELAVFGEGCFWGAERGFW
KLPGVYSTAVGYAGGYTPNPTYEEVCSGRTGHAEVVLVVFDPREVTYGQLLVQFWESHDPTQGMRQGNDRGTQYRSVIYT
TSEGQAVQAAESAARYEAALADAGYGAITTEIAPLNGPVGHASRTFFYAEEYHQQYLAKNPNGYCGLGGTSVSCPIGLDV
PPGGPAEA
>Mature_247_residues
ASWVDNVRDQILGRIEDGLKPGKSAIVAEDAALPGRATPIRVSGTHFVNGHTTVPPFPDGCELAVFGEGCFWGAERGFWK
LPGVYSTAVGYAGGYTPNPTYEEVCSGRTGHAEVVLVVFDPREVTYGQLLVQFWESHDPTQGMRQGNDRGTQYRSVIYTT
SEGQAVQAAESAARYEAALADAGYGAITTEIAPLNGPVGHASRTFFYAEEYHQQYLAKNPNGYCGLGGTSVSCPIGLDVP
PGGPAEA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=215, Percent_Identity=60.4651162790698, Blast_Score=272, Evalue=2e-73,
Organism=Homo sapiens, GI208609995, Length=193, Percent_Identity=62.6943005181347, Blast_Score=257, Evalue=7e-69,
Organism=Homo sapiens, GI208609993, Length=215, Percent_Identity=45.5813953488372, Blast_Score=184, Evalue=5e-47,
Organism=Escherichia coli, GI1790665, Length=213, Percent_Identity=57.7464788732394, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17533973, Length=155, Percent_Identity=37.4193548387097, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=179, Percent_Identity=34.0782122905028, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664627, Length=152, Percent_Identity=36.8421052631579, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664631, Length=152, Percent_Identity=36.1842105263158, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45553131, Length=147, Percent_Identity=36.0544217687075, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26394; Mature: 26263

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASWVDNVRDQILGRIEDGLKPGKSAIVAEDAALPGRATPIRVSGTHFVNGHTTVPPFPD
CCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCEEEECCCEECCCCCC
GCELAVFGEGCFWGAERGFWKLPGVYSTAVGYAGGYTPNPTYEEVCSGRTGHAEVVLVVF
CCEEEEEECCEEECCCCCCEECCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEEEEEEE
DPREVTYGQLLVQFWESHDPTQGMRQGNDRGTQYRSVIYTTSEGQAVQAAESAARYEAAL
CCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHH
ADAGYGAITTEIAPLNGPVGHASRTFFYAEEYHQQYLAKNPNGYCGLGGTSVSCPIGLDV
HCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHCCCCCEEECCCCCEECEEECCC
PPGGPAEA
CCCCCCCC
>Mature Secondary Structure 
ASWVDNVRDQILGRIEDGLKPGKSAIVAEDAALPGRATPIRVSGTHFVNGHTTVPPFPD
CHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCEEEECCCEECCCCCC
GCELAVFGEGCFWGAERGFWKLPGVYSTAVGYAGGYTPNPTYEEVCSGRTGHAEVVLVVF
CCEEEEEECCEEECCCCCCEECCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEEEEEEE
DPREVTYGQLLVQFWESHDPTQGMRQGNDRGTQYRSVIYTTSEGQAVQAAESAARYEAAL
CCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHH
ADAGYGAITTEIAPLNGPVGHASRTFFYAEEYHQQYLAKNPNGYCGLGGTSVSCPIGLDV
HCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHCCCCCEEECCCCCEECEEECCC
PPGGPAEA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]