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The map label for this gene is ksdD [H]

Identifier: 169627186

GI number: 169627186

Start: 77407

End: 79113

Strand: Direct

Name: ksdD [H]

Synonym: MAB_0081

Alternate gene names: 169627186

Gene position: 77407-79113 (Clockwise)

Preceding gene: 169627183

Following gene: 169627188

Centisome position: 1.53

GC content: 66.14

Gene sequence:

>1707_bases
ATGGCGTCAGCACCCCCCGGGCTGATCCCCGCCGGGACCGTCGCAGGTGATATCGAGATCGATCTGCTGATCGTCGGAGC
CGGGACGGGTATGGCTGCCGCACTGGCCGCCAGCGAGCTCGGATTGTCGGTGCTGATCGTCGAGAAGTCGCACCAGGTGG
GCGGGTCTACCGCTCGCTCCGGGGGAGCGCTCTGGCTACCGGCCAGCCCGGTCCTGCGGGCCGCGGGAACGGGTGACTCC
GTGGAGCGGGCGCGTACCTACCTACGGTCGGTGGTCGCGGGCAGCGCGCCGGACGCACGCAGTGACGCCTTTCTGGAACA
TGAAGCGGCGACCGTCGACATGTTGACGAGATTGACCCCGATGCGTTTCACCTGGTGCCGAGATTACGCGGACTACCACC
CGGAGGAACCAGGAGGCAGCCCGACCGGGCGCACCTGCGAATGCCGGCCGTTCGACGCGTCTGTGCTGGGCGAGTACCGG
ACCAGGCTGCAGCCGGGAGTCATGAAGCCCCCGGCAGTACCGATGCCCGTGACCAGCGCTGACTACCGCTGGATGAATTT
GATGGCCCGGCTCCCTCGTAAAGCATTGCCGCTCATCGTAAAGCGAATTGCGCAGGGAGTCGGCGGCGCCGTATTGGGAC
GGCGCTACCTGGCCGGCGGTCAGGCGCTGGCGGCAGGACTCTTCGCGGGAGTGCTGCGCGCGGGGATTCCGATCTGGACC
GGCACCTCACTGGTACGTCTGACCACCGCGGGCGGGCGTGTCACGGGCGCGGTGGTCGCCCTTGCGGGGCGCGAATTCAC
GGTGACGGTCAGCCGGGGCGTGGTGCTGGCGGCCGGCGGCTTCGACCACGACATGGAGATGCGACACAAGTTCCAGTCGG
CGGCACTGGGAGAAAACATGAGCCTGGGCGCCGACACCAACACCGGTGATGCGCTCCGGATCGGTCAGGACTGCGGTGCG
GCAATCGATTCCATGAACCAAGCATGGTGGTTTCCGGCTGTGGCGCCGCTGCCTGGTGGCGCCCCGAAGGTGATGTTGGC
GGAGCGATCGCTTCCGGGATCGTTCATCGTCGATCACACCGGAAACCGCTTCATCAACGAGGCGACTGACTACATGTCGT
TCGGACAGCGGGTACTGGAGCGGGAGCGTTCCGGTGACCCGGCGGAATCGATGTGGATCATCTTCGACCAGCAGTATCGC
AACAGTTATGTCTTTGCGGGCCAGTTGTATCCCCGGATGCCGGTACCCGTCAGCTGGTTCGAAGCCCGGATCGCCTATCG
TGCGGACAGTTTGGCTGATCTTGCGGCCATGATCGGGATACCGAGGGACGCGTTCTTGGCCACGGTGTGCCGTTTCAACG
AATCGGCCGCAGCCGGGGACGACGGTGACTTCCACCGCGGCCGCAGCAGCTACGACCGCTACTACGGTGACCCGACGGTC
ACCCCCAATCCGAATCTGCGCCCGCTGCGGCGCGGGCCGTTCTATGCGGTGCGCATGGTGCTCAGCGACCTGGGGACCTG
CGGTGGCTTGCGTGCTGACGAGCGCGCACGGGTGCTGCGTGAAGACGGCAGTGTCATCAAGGGTCTGTATGCGATCGGCA
ATACCGCCGCCAACGCGTTCGGTGCCACCTATCCGGGTGCCGGGGCAACAATTGCGCAGGGACTCGTCTACGGATACATC
GCGGCACATGACGCGGCCGCGCGGTGA

Upstream 100 bases:

>100_bases
TTGCGATCACCTCCCGCTGGGAGGGAAACGTGACCGCAGCCCGCTGCTCGTCGGCTTAGCCTCGGCGCCGTCCACGTGAA
TTCGACGGAGGTATGCACAG

Downstream 100 bases:

>100_bases
TCAGTCCGCCGTATCGTGCTGTGTAGAAAGCTTTTCGGCGTCCACTCGCTTCTCGACCTCACGCCAGTAGCCGGGAACGA
GGCGAGGTGTTCCACCGTCC

Product: 3-ketosteroid-delta-1-dehydrogenase

Products: NA

Alternate protein names: 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MASAPPGLIPAGTVAGDIEIDLLIVGAGTGMAAALAASELGLSVLIVEKSHQVGGSTARSGGALWLPASPVLRAAGTGDS
VERARTYLRSVVAGSAPDARSDAFLEHEAATVDMLTRLTPMRFTWCRDYADYHPEEPGGSPTGRTCECRPFDASVLGEYR
TRLQPGVMKPPAVPMPVTSADYRWMNLMARLPRKALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWT
GTSLVRLTTAGGRVTGAVVALAGREFTVTVSRGVVLAAGGFDHDMEMRHKFQSAALGENMSLGADTNTGDALRIGQDCGA
AIDSMNQAWWFPAVAPLPGGAPKVMLAERSLPGSFIVDHTGNRFINEATDYMSFGQRVLERERSGDPAESMWIIFDQQYR
NSYVFAGQLYPRMPVPVSWFEARIAYRADSLADLAAMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTV
TPNPNLRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNTAANAFGATYPGAGATIAQGLVYGYI
AAHDAAAR

Sequences:

>Translated_568_residues
MASAPPGLIPAGTVAGDIEIDLLIVGAGTGMAAALAASELGLSVLIVEKSHQVGGSTARSGGALWLPASPVLRAAGTGDS
VERARTYLRSVVAGSAPDARSDAFLEHEAATVDMLTRLTPMRFTWCRDYADYHPEEPGGSPTGRTCECRPFDASVLGEYR
TRLQPGVMKPPAVPMPVTSADYRWMNLMARLPRKALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWT
GTSLVRLTTAGGRVTGAVVALAGREFTVTVSRGVVLAAGGFDHDMEMRHKFQSAALGENMSLGADTNTGDALRIGQDCGA
AIDSMNQAWWFPAVAPLPGGAPKVMLAERSLPGSFIVDHTGNRFINEATDYMSFGQRVLERERSGDPAESMWIIFDQQYR
NSYVFAGQLYPRMPVPVSWFEARIAYRADSLADLAAMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTV
TPNPNLRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNTAANAFGATYPGAGATIAQGLVYGYI
AAHDAAAR
>Mature_567_residues
ASAPPGLIPAGTVAGDIEIDLLIVGAGTGMAAALAASELGLSVLIVEKSHQVGGSTARSGGALWLPASPVLRAAGTGDSV
ERARTYLRSVVAGSAPDARSDAFLEHEAATVDMLTRLTPMRFTWCRDYADYHPEEPGGSPTGRTCECRPFDASVLGEYRT
RLQPGVMKPPAVPMPVTSADYRWMNLMARLPRKALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWTG
TSLVRLTTAGGRVTGAVVALAGREFTVTVSRGVVLAAGGFDHDMEMRHKFQSAALGENMSLGADTNTGDALRIGQDCGAA
IDSMNQAWWFPAVAPLPGGAPKVMLAERSLPGSFIVDHTGNRFINEATDYMSFGQRVLERERSGDPAESMWIIFDQQYRN
SYVFAGQLYPRMPVPVSWFEARIAYRADSLADLAAMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTVT
PNPNLRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNTAANAFGATYPGAGATIAQGLVYGYIA
AHDAAAR

Specific function: Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids. Is also involved in the formation of 1,4- androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.3.99.4 [H]

Molecular weight: Translated: 60277; Mature: 60146

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAPPGLIPAGTVAGDIEIDLLIVGAGTGMAAALAASELGLSVLIVEKSHQVGGSTARS
CCCCCCCCCCCCCEECCEEEEEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
GGALWLPASPVLRAAGTGDSVERARTYLRSVVAGSAPDARSDAFLEHEAATVDMLTRLTP
CCEEEECCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
MRFTWCRDYADYHPEEPGGSPTGRTCECRPFDASVLGEYRTRLQPGVMKPPAVPMPVTSA
CHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DYRWMNLMARLPRKALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWT
CHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEC
GTSLVRLTTAGGRVTGAVVALAGREFTVTVSRGVVLAAGGFDHDMEMRHKFQSAALGENM
CCCEEEEEECCCCEEEEEEEEECCEEEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCC
SLGADTNTGDALRIGQDCGAAIDSMNQAWWFPAVAPLPGGAPKVMLAERSLPGSFIVDHT
CCCCCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECC
GNRFINEATDYMSFGQRVLERERSGDPAESMWIIFDQQYRNSYVFAGQLYPRMPVPVSWF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHH
EARIAYRADSLADLAAMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
TPNPNLRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNTAANAF
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHC
GATYPGAGATIAQGLVYGYIAAHDAAAR
CCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASAPPGLIPAGTVAGDIEIDLLIVGAGTGMAAALAASELGLSVLIVEKSHQVGGSTARS
CCCCCCCCCCCCEECCEEEEEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
GGALWLPASPVLRAAGTGDSVERARTYLRSVVAGSAPDARSDAFLEHEAATVDMLTRLTP
CCEEEECCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
MRFTWCRDYADYHPEEPGGSPTGRTCECRPFDASVLGEYRTRLQPGVMKPPAVPMPVTSA
CHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DYRWMNLMARLPRKALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWT
CHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEC
GTSLVRLTTAGGRVTGAVVALAGREFTVTVSRGVVLAAGGFDHDMEMRHKFQSAALGENM
CCCEEEEEECCCCEEEEEEEEECCEEEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCC
SLGADTNTGDALRIGQDCGAAIDSMNQAWWFPAVAPLPGGAPKVMLAERSLPGSFIVDHT
CCCCCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECC
GNRFINEATDYMSFGQRVLERERSGDPAESMWIIFDQQYRNSYVFAGQLYPRMPVPVSWF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHH
EARIAYRADSLADLAAMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
TPNPNLRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNTAANAF
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHC
GATYPGAGATIAQGLVYGYIAAHDAAAR
CCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA