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The map label for this gene is lip2 [H]

Identifier: 169627183

GI number: 169627183

Start: 74906

End: 75826

Strand: Direct

Name: lip2 [H]

Synonym: MAB_0078

Alternate gene names: 169627183

Gene position: 74906-75826 (Clockwise)

Preceding gene: 169627182

Following gene: 169627186

Centisome position: 1.48

GC content: 66.56

Gene sequence:

>921_bases
GTGACCCTCGATCCTCAGCTGGCCGCCCTGCTACCGGCGCTCAATGCGGGCTTTCCGCGCGTCGAGAAGATGACGGGTGC
ACAGGCGCGGGCCGCAATCCGTGCCCGATACGTTCCGCCGGCCAGGCCACTGCCGATGCGTTCGGTGACCGACGAGTGCG
TGTACGCCTTCGGCGGAGAGCTACCGATCCGCGTCTATCGTCCTGCCGTGCCCGGACCGCTGCCCACTGTTGTCTTTGCG
CACGGCGGCGGATTCGTATTCTGCGACTTGGACTCTCATGACGGACTATGTCGTCGTTTGGCAGCCGGGATTCCCGCCGT
GGTGGTGTCTGTCGACTATCGACGCGCCCCGGAGCACCGATGGCCGACGGCGGCGCAGGACATGTTCCTGGCGGCGTGCT
GGGTGACACGCAATGCCCCCACGTTGGGGGGTGATCCCGCGCGGGTGCTGGTGTGCGGTGACAGCGCGGGAGGAAATCTG
GCGGCGGTGACCACATTGATGGCCCGGGATCTGGGGGGACCCGTACTGGCGGGCCAGATCCTGATTTACCCCGTCTTGGA
CGCAGACTTCGATACCCCCTCGTACCGCAGCTGCGGCTCCGGGTACTACAACACGCGAGCTGCGATGCAGTGGTACTGGG
ATCAGTACCTGCCCGACCCGGCATTACGCGACCACCCGTACGCGGCTCCGCTGCGCGCCGACCTGAGCGGGTTGCCACCT
GCGGTGGTGGTGACGGCGCGCTATGACCCGCCATGCAGCGAGGGCGAGGCCTATGCGGCGGCGCTGCGCGAAGCAGGCGT
GCCGGTACGGTATCGACGCTACGACAATGCGATTCACGGATTCATGACCATGCCAGGCCTGGAGCTGGCGGATGCGGGGA
TCCAGCGACTGTGCCGCGATGTCGGCGAAATGCTTGGTTAG

Upstream 100 bases:

>100_bases
GCCGAGTGGCCCCGACCTTGCAGCCGATTCGCCCACTGCGTTGCGGTCCCGCCGCCTCCTCAACTGGACGCGAGATGAAC
TCGCCCGCATTGCAGTACGC

Downstream 100 bases:

>100_bases
CCGCCGTACTCCTCGGCGAGCACGGGCAGCCGGCCGCTGTGCGCGGCATCGAGAATCGAGCTGCGCAACTCCGAGCACAC
CAGGAACAGGCCGGTGCAGT

Product: putative lipase/esterase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTLDPQLAALLPALNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRSVTDECVYAFGGELPIRVYRPAVPGPLPTVVFA
HGGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAACWVTRNAPTLGGDPARVLVCGDSAGGNL
AAVTTLMARDLGGPVLAGQILIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHPYAAPLRADLSGLPP
AVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHGFMTMPGLELADAGIQRLCRDVGEMLG

Sequences:

>Translated_306_residues
MTLDPQLAALLPALNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRSVTDECVYAFGGELPIRVYRPAVPGPLPTVVFA
HGGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAACWVTRNAPTLGGDPARVLVCGDSAGGNL
AAVTTLMARDLGGPVLAGQILIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHPYAAPLRADLSGLPP
AVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHGFMTMPGLELADAGIQRLCRDVGEMLG
>Mature_305_residues
TLDPQLAALLPALNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRSVTDECVYAFGGELPIRVYRPAVPGPLPTVVFAH
GGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAACWVTRNAPTLGGDPARVLVCGDSAGGNLA
AVTTLMARDLGGPVLAGQILIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHPYAAPLRADLSGLPPA
VVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHGFMTMPGLELADAGIQRLCRDVGEMLG

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=307, Percent_Identity=28.0130293159609, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI68299767, Length=313, Percent_Identity=28.7539936102236, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI206597554, Length=314, Percent_Identity=27.7070063694268, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI61966717, Length=143, Percent_Identity=36.3636363636364, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI157041237, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI68051721, Length=167, Percent_Identity=35.3293413173653, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI226423947, Length=175, Percent_Identity=33.7142857142857, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI21328446, Length=108, Percent_Identity=37.962962962963, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786682, Length=229, Percent_Identity=29.6943231441048, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567059, Length=266, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540028, Length=159, Percent_Identity=38.3647798742138, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71996133, Length=152, Percent_Identity=36.8421052631579, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI72001146, Length=123, Percent_Identity=39.8373983739837, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533412, Length=90, Percent_Identity=34.4444444444444, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533410, Length=84, Percent_Identity=35.7142857142857, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656084, Length=148, Percent_Identity=34.4594594594595, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24656076, Length=148, Percent_Identity=34.4594594594595, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20130169, Length=148, Percent_Identity=34.4594594594595, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32944; Mature: 32813

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDPQLAALLPALNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRSVTDECVYAFGGE
CCCCHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCC
LPIRVYRPAVPGPLPTVVFAHGGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHR
CCEEEECCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCCCCC
WPTAAQDMFLAACWVTRNAPTLGGDPARVLVCGDSAGGNLAAVTTLMARDLGGPVLAGQI
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEECEE
LIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHPYAAPLRADLSGLPP
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCC
AVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHGFMTMPGLELADAGIQRLCRD
EEEEEECCCCCCCCCHHHHHHHHHCCCCEEEHHHCCHHHHHHCCCCHHHHHHHHHHHHHH
VGEMLG
HHHHCC
>Mature Secondary Structure 
TLDPQLAALLPALNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRSVTDECVYAFGGE
CCCHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCC
LPIRVYRPAVPGPLPTVVFAHGGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHR
CCEEEECCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCCCCC
WPTAAQDMFLAACWVTRNAPTLGGDPARVLVCGDSAGGNLAAVTTLMARDLGGPVLAGQI
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEECEE
LIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHPYAAPLRADLSGLPP
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCC
AVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYDNAIHGFMTMPGLELADAGIQRLCRD
EEEEEECCCCCCCCCHHHHHHHHHCCCCEEEHHHCCHHHHHHCCCCHHHHHHHHHHHHHH
VGEMLG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]