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The map label for this gene is gnD [H]

Identifier: 169627111

GI number: 169627111

Start: 3419

End: 4312

Strand: Direct

Name: gnD [H]

Synonym: MAB_0003

Alternate gene names: 169627111

Gene position: 3419-4312 (Clockwise)

Preceding gene: 169627110

Following gene: 169627112

Centisome position: 0.07

GC content: 63.42

Gene sequence:

>894_bases
ATGCAGCTGGGTTTGGTCGGGCTAGGCAAGATGGGTTTCAACATGCGCGACCGGTTGCGTGCCGGCGGCCATGAGGTGAT
CGGATACGACCCTCGGCCCGAGGTCACCGACGTGCCGTCACTGAAAGGGCTGGCCGAGGCGCTCGACGCGCCGCGCGTCG
TTTGGGTGATGGTGCCATCGGGCCCGATCACCCAGCAGACAATCGCCGAGCTATCGGAGGAATTGTCCGAGGGCGACCTC
GTCATAGACGGCGGTAACTCACGGTTCACCGAGGACAAGCCGAACGCAGATCTACTGGCGGCCAAGGGTATTGGTTATAT
CGACGCCGGAGTCTCCGGTGGGGTGTGGGGCAAAGAAAACGGCTACGGGCTCATGGTCGGCGGCAGTGACGAGGATGTGG
CGCGGGCGATGCCGATCTTCGACACACTGCGTCCCGAGGGTGAGCGCGCCGACGGCTTTGTCCACGCGGGCCCTGTGGGA
GCCGGCCACTACGCAAAGATGATCCATAACGGCATCGAGTACGGGCTCATGCACGCCTATGCGGAGGGTTATGAGTTGCT
GGCCGCCGAGCCACTCATCACCGACGTGCAGGCGGTGCTGCAGGCGTGGACCAAGGGCACCGTGGTGCGGTCTTGGCTGC
TAGACCTGCTGGCCAAGGCCTTGAAGGAAGACCCCGGCTTCGATGCTATTTCGGGGTACACGGAAGATTCCGGTGAGGGC
CGCTGGACCGTGGAAGAAGCAATTAATCATCGGGTTCCGGCGCCGGTCATCGCGGCCTCGCTATTCGCGAGATTCGCGTC
ACGGCAAGAGGACTCACCGGCAATGAAGGCTGTCTCGGCATTGCGCAACCAGTTTGGTGGCCACGCGGTCAAGCGCGTGG
GCCTTTCCGGCTGA

Upstream 100 bases:

>100_bases
CGCAAACTGACTATGTCTATCTATTGATGCCGGTGCGTCTGCCCGGCTAGGGCTTGCGCTCCTAACAGCATCACGGACTG
GTCATCGGAGGTTATGGGTC

Downstream 100 bases:

>100_bases
GGGAGGCGCGCGGACCGAGGTGTATGTACGACAGCTGGGATTACGGGACTTCCGGTCATGGGAGCGTGTCAACCTGGAAC
TCGAGCCCGGCCGCACGGTG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQLGLVGLGKMGFNMRDRLRAGGHEVIGYDPRPEVTDVPSLKGLAEALDAPRVVWVMVPSGPITQQTIAELSEELSEGDL
VIDGGNSRFTEDKPNADLLAAKGIGYIDAGVSGGVWGKENGYGLMVGGSDEDVARAMPIFDTLRPEGERADGFVHAGPVG
AGHYAKMIHNGIEYGLMHAYAEGYELLAAEPLITDVQAVLQAWTKGTVVRSWLLDLLAKALKEDPGFDAISGYTEDSGEG
RWTVEEAINHRVPAPVIAASLFARFASRQEDSPAMKAVSALRNQFGGHAVKRVGLSG

Sequences:

>Translated_297_residues
MQLGLVGLGKMGFNMRDRLRAGGHEVIGYDPRPEVTDVPSLKGLAEALDAPRVVWVMVPSGPITQQTIAELSEELSEGDL
VIDGGNSRFTEDKPNADLLAAKGIGYIDAGVSGGVWGKENGYGLMVGGSDEDVARAMPIFDTLRPEGERADGFVHAGPVG
AGHYAKMIHNGIEYGLMHAYAEGYELLAAEPLITDVQAVLQAWTKGTVVRSWLLDLLAKALKEDPGFDAISGYTEDSGEG
RWTVEEAINHRVPAPVIAASLFARFASRQEDSPAMKAVSALRNQFGGHAVKRVGLSG
>Mature_297_residues
MQLGLVGLGKMGFNMRDRLRAGGHEVIGYDPRPEVTDVPSLKGLAEALDAPRVVWVMVPSGPITQQTIAELSEELSEGDL
VIDGGNSRFTEDKPNADLLAAKGIGYIDAGVSGGVWGKENGYGLMVGGSDEDVARAMPIFDTLRPEGERADGFVHAGPVG
AGHYAKMIHNGIEYGLMHAYAEGYELLAAEPLITDVQAVLQAWTKGTVVRSWLLDLLAKALKEDPGFDAISGYTEDSGEG
RWTVEEAINHRVPAPVIAASLFARFASRQEDSPAMKAVSALRNQFGGHAVKRVGLSG

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=293, Percent_Identity=32.0819112627986, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788341, Length=292, Percent_Identity=32.8767123287671, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17542558, Length=292, Percent_Identity=32.5342465753425, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321695, Length=292, Percent_Identity=32.8767123287671, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6321977, Length=303, Percent_Identity=31.023102310231, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24639279, Length=300, Percent_Identity=30.6666666666667, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 31625; Mature: 31625

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGLVGLGKMGFNMRDRLRAGGHEVIGYDPRPEVTDVPSLKGLAEALDAPRVVWVMVPS
CCCCCEECCCCCCCHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECC
GPITQQTIAELSEELSEGDLVIDGGNSRFTEDKPNADLLAAKGIGYIDAGVSGGVWGKEN
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCC
GYGLMVGGSDEDVARAMPIFDTLRPEGERADGFVHAGPVGAGHYAKMIHNGIEYGLMHAY
CCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
AEGYELLAAEPLITDVQAVLQAWTKGTVVRSWLLDLLAKALKEDPGFDAISGYTEDSGEG
HHCHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCC
RWTVEEAINHRVPAPVIAASLFARFASRQEDSPAMKAVSALRNQFGGHAVKRVGLSG
CEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCC
>Mature Secondary Structure
MQLGLVGLGKMGFNMRDRLRAGGHEVIGYDPRPEVTDVPSLKGLAEALDAPRVVWVMVPS
CCCCCEECCCCCCCHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECC
GPITQQTIAELSEELSEGDLVIDGGNSRFTEDKPNADLLAAKGIGYIDAGVSGGVWGKEN
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCC
GYGLMVGGSDEDVARAMPIFDTLRPEGERADGFVHAGPVGAGHYAKMIHNGIEYGLMHAY
CCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
AEGYELLAAEPLITDVQAVLQAWTKGTVVRSWLLDLLAKALKEDPGFDAISGYTEDSGEG
HHCHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCC
RWTVEEAINHRVPAPVIAASLFARFASRQEDSPAMKAVSALRNQFGGHAVKRVGLSG
CEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]