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The map label for this gene is pbuX [H]

Identifier: 169834427

GI number: 169834427

Start: 1824073

End: 1825335

Strand: Direct

Name: pbuX [H]

Synonym: SPH_1963

Alternate gene names: 169834427

Gene position: 1824073-1825335 (Clockwise)

Preceding gene: 169833722

Following gene: 169833436

Centisome position: 81.23

GC content: 45.92

Gene sequence:

>1263_bases
ATGCAAACTCAAGAAAAACACTCGCAAGCAGCCGTTCTTGGCTTGCAGCACTTACTAGCCATGTACTCAGGATCTATCCT
GGTTCCCATCATGATTGCGACAGCCCTTGGCTATTCAGCTGAGCAGTTGACCTACCTGATTTCTACAGATATCTTCATGT
GTGGGGTGGCAACCTTCCTCCAACTCCAACTCAACAAATACTTTGGGATTGGACTCCCAGTCGTTCTTGGAGTTGCATTC
CAGTCGGTCGCTCCCTTGATTATGATTGGGCAAAGCCATGGTAGTGGCGCTATGTTTGGTGCCCTTATCGCATCTGGGAT
TTACGTGGTTCTTGTTTCAGGCATCTTCTCAAAAGTAGCCAATCTCTTCCCATCTATCGTAACAGGATCTGTTATTACCA
CGATTGGTTTAACCTTGATCCCTGTCGCTATTGGAAATATGGGAAATAACGTTCCAGAGCCAACTGGTCAAAGTCTCTTG
CTTGCAGCTATTACTGTTCTGATTATCCTCTTGATCAACATCTTTACCAAAGGATTTATCAAGTCTATCTCTATTTTGAT
TGGTCTGGTTGTTGGAACTGCCATTGCTGCTACTATGGGCTTGGTGGACTTCTCTCCTGTTGCGGTAGCTCCACTTGTCC
ATGTCCCAACTCCACTCTACTTTGGGATGCCAACCTTTGAAATCTCATCTATTGCCATGATGTGTATCATCGCAACGGTG
TCTATGGTTGAGTCAACTGGTGTTTATCTAGCCTTGTCTGATATCACAAAAGATCCAATCGACAGCACGCGCCTTCGCAA
CGGTTACCGCGCAGAAGGTTTGGCGGTACTTCTCGGAGGAATCTTTAACACCTTCCCTTACACCGGATTTTCACAAAACG
TTGGTTTGGTTAAATTGTCAGGCATCAAAAAACGCCTGCCAATCTACTACGCAGCTGGTTTCCTGGTTCTCCTTGGACTG
CTTCCTAAGTTTGGTGCCCTTGCCCAAATCATTCCAAGCTCCGTCCTCGGCGGTGCCATGCTGGTGATGTTTGGTTTTGT
ATCTATTCAAGGGATGCAAATCCTCGCCCGAGTTGACTTTGCTAACAATGAACACAACTTCCTTATCGCAGCTGTTTCAA
TCGCTGCAGGTGTCGGTCTCAACAACAGTAATCTCTTTGTCAGCATGCCGACAGCCTTCCAAATGTTCTTCTCAAACGGA
ATCGTCGTAGCCAGCCTACTCGCTATTGTCCTCAATGCCGTATTAAATCATAAAAAGAAATAA

Upstream 100 bases:

>100_bases
GCCGTGATTTGCTTGAAAAAGCAGGCTACCCTGTCCTATCACTTGCTCGTTTGGATCGTTTTGAAAATGGTCAGGTCGTA
TTTAAGGAGGCAGATCTCTA

Downstream 100 bases:

>100_bases
GAAAAAGAGGTGCGAGCCTCTTTTTTGTTTATCACAAATTGATTATAAATACAATCAATCCCAATTCCCATCTAATTGAA
TTGGACCTATTTCAAATTCT

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAF
QSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
LAAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIAMMCIIATV
SMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGL
LPKFGALAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNG
IVVASLLAIVLNAVLNHKKK

Sequences:

>Translated_420_residues
MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAF
QSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
LAAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIAMMCIIATV
SMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGL
LPKFGALAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNG
IVVASLLAIVLNAVLNHKKK
>Mature_420_residues
MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAF
QSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
LAAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIAMMCIIATV
SMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGL
LPKFGALAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNG
IVVASLLAIVLNAVLNHKKK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=429, Percent_Identity=25.6410256410256, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI40316845, Length=429, Percent_Identity=25.6410256410256, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI44680143, Length=178, Percent_Identity=27.5280898876405, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI44680145, Length=178, Percent_Identity=27.5280898876405, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082181, Length=416, Percent_Identity=39.6634615384615, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1790087, Length=443, Percent_Identity=31.6027088036117, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082178, Length=435, Percent_Identity=29.1954022988506, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87081818, Length=431, Percent_Identity=29.4663573085847, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788843, Length=388, Percent_Identity=29.639175257732, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17542262, Length=176, Percent_Identity=27.8409090909091, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541904, Length=135, Percent_Identity=28.8888888888889, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21356175, Length=169, Percent_Identity=32.5443786982249, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44124; Mature: 44124

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFL
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVA
HHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLLLAAITVLIILLINIFTKGFI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIAMMCIIATV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHH
SMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLS
HHHHCCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEC
GIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDF
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
ANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNGIVVASLLAIVLNAVLNHKKK
CCCCCCEEEEEEHHHHCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFL
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVA
HHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLLLAAITVLIILLINIFTKGFI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIAMMCIIATV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHH
SMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLS
HHHHCCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEC
GIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDF
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
ANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNGIVVASLLAIVLNAVLNHKKK
CCCCCCEEEEEEHHHHCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]