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The map label for this gene is purM [H]

Identifier: 169833754

GI number: 169833754

Start: 129952

End: 130974

Strand: Direct

Name: purM [H]

Synonym: SPH_0154

Alternate gene names: 169833754

Gene position: 129952-130974 (Clockwise)

Preceding gene: 169833656

Following gene: 169834363

Centisome position: 5.79

GC content: 47.12

Gene sequence:

>1023_bases
ATGACAAATAAAAATGCATATGCCCAGTCGGGTGTGGATGTTGAAGCGGGTTATGAAGTTGTTGAACGGATTAAAAAGCA
CGTGGCCCGTACGGAGCGTGCAGGTGTCATGGGAGCTCTTGGTGGCTTTGGTGGTATGTTTGACCTTTCCAAGACTGGGG
TTAAAGAACCCGTCTTGATTTCAGGGACTGACGGTGTCGGAACCAAGCTCATGTTGGCTATCAAGTACGACAAGCACGAT
ACCATCGGGCAGGACTGTGTGGCCATGTGTGTCAACGACATCATTGCTGCAGGTGCGGAACCCCTCTATTTTCTCGACTA
CGTAGCGACAGGGAAGAATGAACCAGCTAAGCTAGAACAAGTGGTTGCTGGTGTGGCAGAAGGTTGTGTGCAGGCTGGTG
CTGCCCTCATCGGTGGGGAAACGGCTGAAATGCCGGGCATGTACGGCGAAGACGACTATGACTTGGCTGGTTTTGCGGTC
GGTGTGGCTGAAAAATCTCAAATCATTGACGGTTCAAAGGTGGTAGAGGGAGATGTTCTTCTCGGACTTGCTTCAAGTGG
GATTCACTCAAATGGTTACTCTTTGGTTCGTCGTGTCTTTGCGGATTACACAGGTGAGGAAGTCCTACCAGAATTGGAAG
GCAAGAAACTTAAGGAAGTTCTACTTGAGCCGACTCGTATCTATGTCAAGGCTGTCTTGCCGCTCATCAAAGAAGAGTTG
GTCAACGGCATTGCCCACATCACAGGTGGTGGCTTTATCGAAAATGTCCCTCGTATGTTTGCAGATGACCTAGCTGCTGA
AATTGATGAAAGCAAAGTTCCAGTGCTTCCAATTTTCAAAGCCCTTGAAAAATATGGTCAGATTAAACACGAAGAAATGT
TTGAAATCTTCAATATGGGTGTGGGACTTATGTTGGCGGTCAGCCCTGAAAATGTAGAGCGTGTAAAAGAATTGTTGGAT
GAAGCAGTCTATGAAATTGGTCGCATCGTCAAGAAAGAAAACGAAAGTGTCATTATCAAATGA

Upstream 100 bases:

>100_bases
TCTTTATGACTACGAAGAAGACTATCGTAGAAGTTTGGAAGAAAAGACCAGTTTTTACAAGTAGGCGACAGATTCTCCAT
TAAAGAAAAGGAAAAAACAA

Downstream 100 bases:

>100_bases
AAAAAATAGCGGTTTTTGCCTCTGGTAATGGCTCAAATTTTCAGGTGATTGCCGAAGAATTTCCAGTGGAGTTTGTCTTT
TCAGACCATCGTGATGCCTA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHD
TIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
GVAEKSQIIDGSKVVEGDVLLGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVLPLIKEEL
VNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLD
EAVYEIGRIVKKENESVIIK

Sequences:

>Translated_340_residues
MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHD
TIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
GVAEKSQIIDGSKVVEGDVLLGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVLPLIKEEL
VNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLD
EAVYEIGRIVKKENESVIIK
>Mature_339_residues
TNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHDT
IGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAVG
VAEKSQIIDGSKVVEGDVLLGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVLPLIKEELV
NGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLDE
AVYEIGRIVKKENESVIIK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=47.2140762463343, Blast_Score=311, Evalue=4e-85,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=47.2140762463343, Blast_Score=311, Evalue=4e-85,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=47.2140762463343, Blast_Score=311, Evalue=4e-85,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=52.3255813953488, Blast_Score=349, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17567511, Length=341, Percent_Identity=41.9354838709677, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=340, Percent_Identity=45.8823529411765, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24582400, Length=272, Percent_Identity=44.1176470588235, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36502; Mature: 36371

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVKEPVLI
CCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEE
SGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAKLEQ
ECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHH
VVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQIIDGSKVVEGDVL
HHHHHHHHHHHHCHHHHCCCHHCCCCCCCCCCCCHHHHEEEHHHHHHHCCCCCEEECCEE
LGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVLPLIKEEL
EEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHH
VNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHEEMFEIFNMG
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCC
VGLMLAVSPENVERVKELLDEAVYEIGRIVKKENESVIIK
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
TNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVKEPVLI
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEE
SGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAKLEQ
ECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHH
VVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQIIDGSKVVEGDVL
HHHHHHHHHHHHCHHHHCCCHHCCCCCCCCCCCCHHHHEEEHHHHHHHCCCCCEEECCEE
LGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVLPLIKEEL
EEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHH
VNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHEEMFEIFNMG
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCC
VGLMLAVSPENVERVKELLDEAVYEIGRIVKKENESVIIK
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA