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The map label for this gene is proC [H]

Identifier: 169833427

GI number: 169833427

Start: 963503

End: 964300

Strand: Direct

Name: proC [H]

Synonym: SPH_1042

Alternate gene names: 169833427

Gene position: 963503-964300 (Clockwise)

Preceding gene: 169832615

Following gene: 169832724

Centisome position: 42.91

GC content: 44.86

Gene sequence:

>798_bases
ATGAAGATTGGATTTATCGGTTTGGGGAATATGGGTGCTAGTTTAGCCAAGTCTGTCTTGCAGGCTAGACCGTCAGATGA
GATTCTCCTTGCCAATCGTAGTCAAGTCAAGGTGGATGCTTTCATCGCTAACTTCGGTGGTCAGACTTCTAACAATGAAG
AAATATTCGAAGAAGCAGATGTGATTTTTCTAGGTGTTAAGCCTGCTCAGTTTTCTGAACTGCTTTCTCAATACCAGACC
ATCCTTGAAAAAAGAGAAAGTCTTCTTTTGATTTCGATGGCAGCTGGATTGATCTTAGAAAAACTAGCAAGTCTTATCCC
AAGCCAACACCGAATTATTCGTATGATGCCTAATACCCCTGCTTCTATCGGGCAAGGAGTGATTAGTTATGCCTTGTCTC
CTAATTGCAGGGCTGAGGACAGTGAGCTCTTTTGTCAGCTTTTATCCAAGGCTGGTCTCTTGGTTGAATTAGGAGAAAGC
TTAATCAATGCAGCGACAGGTCTTGCAGGCTGTGGACCAGCCTTTGTCTATCTCTTTATTGAGGCCTTGGCAGATGCAGG
TGTTCAGACGGGATTACCACGAGAAACAGCCTTGAAAATGGCAGCCCAAACTGTGGTAGGAGCTGGGCAATTGGTCCTAG
AAAGCCAGCAACATCCTGGAGTTTTGAAAGATCAAGTTTGTAGTCCAGGCGGTTCGACTATTGCTGGCGTAGCAAGCCTA
GAAGCGCATGCTTTTCGAGGAACGGTCATGGAGGCAGTTCATCAAGCCTATAAACGAACACAAGAACTAGGTAAATAA

Upstream 100 bases:

>100_bases
TTCTACTCAGAAATTGCACGCGCGTGGTCCAATGGGCTTGAAGGAATTGACTAGCTACAAGTATGTGGTCACTGGTGATG
GACAGATAAGGGAGTAAGAG

Downstream 100 bases:

>100_bases
GAGGTAGTTTTATCTGCCTCTTTTATGGTGGTTGATACTCTTCGAAAATCAAATTCAAACTGCGTCAGCTTCACCTTGCC
GTACTCAAGTACAGCCTGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIANFGGQTSNNEEIFEEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLILEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGTVMEAVHQAYKRTQELGK

Sequences:

>Translated_265_residues
MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIANFGGQTSNNEEIFEEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLILEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGTVMEAVHQAYKRTQELGK
>Mature_265_residues
MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIANFGGQTSNNEEIFEEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLILEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGTVMEAVHQAYKRTQELGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=277, Percent_Identity=38.9891696750903, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=39.3501805054152, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=37.2693726937269, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=31.9548872180451, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=39.1791044776119, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=39.9253731343284, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=33.9285714285714, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320861, Length=215, Percent_Identity=35.8139534883721, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=39.7849462365591, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21358587, Length=274, Percent_Identity=36.4963503649635, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=41.0714285714286, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28041; Mature: 28041

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIANFGGQTSNNEEIFEEAD
CEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCC
VIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLILEKLASLIPSQHRIIRMMPNTP
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
ASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGESLINAATGLAGCGPAFVYLFI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
HHHHHCCHHCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHCCCCCCHHHHHHHH
EAHAFRGTVMEAVHQAYKRTQELGK
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIANFGGQTSNNEEIFEEAD
CEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCC
VIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLILEKLASLIPSQHRIIRMMPNTP
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
ASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGESLINAATGLAGCGPAFVYLFI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
HHHHHCCHHCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHCCCCCCHHHHHHHH
EAHAFRGTVMEAVHQAYKRTQELGK
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]