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The map label for this gene is proA [H]

Identifier: 169832615

GI number: 169832615

Start: 962237

End: 963499

Strand: Direct

Name: proA [H]

Synonym: SPH_1041

Alternate gene names: 169832615

Gene position: 962237-963499 (Clockwise)

Preceding gene: 169832926

Following gene: 169833427

Centisome position: 42.85

GC content: 45.29

Gene sequence:

>1263_bases
ATGGTGAGTAGACAAGAACAATTTGAACAGGTACAGGCTGTTAAAAAATCGATTAACACAGCTAGTGAAGAAGTGAAAAA
TCAAGCCTTGCTAGCCATGGCTGATCACTTAGTGGCTGCTACTGAGGAAATTTTAGCGGCTAATGCCCTCGATATGGCAG
CGGCTAAGGGGAAAATCTCAGATGTGATGTTGGATCGTCTTTATTTGGATGCAGATCGTATAGAAGCGATGGCAAGAGGA
ATTCGTGAAGTGGTTGCCTTACCAGATCCAATCGGTGAAGTTTTAGAAACAAGTCAGCTTGAAAATGGTTTGGTTATCAC
AAAAAAACGTGTAGCTATGGGTGTCATCGGTATTATCTATGAAAGCCGTCCAAATGTGACGTCTGATGCGGCTGCTTTGA
CTCTTAAGAGTGGAAATGCGGTTGTTCTTCGTAGTGGTAAGGATGCCTATCAAACAACCCATGCCATTGTCACAGCCTTG
AAGAAGGGCTTGGAGACGACTACTATTCACCCAAATGTGATTCAACTGGTGGAAGATACTAGCCATGAAAGTAGTTATGC
TATGATGAAGGCCAAGGGCTATCTAGACCTCCTCATTCCTCGTGGAGGAGCTGGCTTGATCAATGCAGTGGTTGAGAATG
CGATTGTACCTGTTATCGAGACAGGGACTGGGATTGTCCATGTCTATGTGGATAAGGATGCAGACGAAGACAAGGCGCTG
TCTATCATCAACAATGCTAAAACCAGTCGTCCTTCTGTTTGTAATGCCATGGAGGTTCTGCTGGTTCATGAAGATAAGGC
AGCAAGCATCCTTCCTCGCTTGGATCAAATGCTGGTTGCAGAGCGTAAGGAAGCTGGACTGGAACCAATTCAATTCCGCT
TGGATAGCAAAGCAAGCCAGTTTGTTTCAGGTCAAGCAGCTGAGACCCAAGACTTTGACACCGAGTTTTTAGACTATGTC
CTTGCTGTTAAGGTTGTGAGCAGTTTAGAAGAAGCGGTTGCGCACATTGAATCCCACAGCACCCATCATTCGGATGCTAT
TGTGACGGAAAATGCTGAAGCTGCAGCATACTTTACAGATCAAGTGGACTCTGCAGCGGTGTATGTTAATGCCTCAACTC
GTTTCACAGATGGAGGACAATTTGGTCTTGGTTGTGAAATGGGGATTTCTACTCAGAAATTGCACGCGCGTGGTCCAATG
GGCTTGAAGGAATTGACTAGCTACAAGTATGTGGTCACTGGTGATGGACAGATAAGGGAGTAA

Upstream 100 bases:

>100_bases
GCGTTCTCAAAAAGCCAAGGGTGTCTTGATTTACCGTGACGACTGGATTTCCATTACTCCTGAAATCCAACTACTTTTTA
CAGAATTTTAGAGGTAAACT

Downstream 100 bases:

>100_bases
GAGATGAAGATTGGATTTATCGGTTTGGGGAATATGGGTGCTAGTTTAGCCAAGTCTGTCTTGCAGGCTAGACCGTCAGA
TGAGATTCTCCTTGCCAATC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARG
IREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
KKGLETTTIHPNVIQLVEDTSHESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
SIINNAKTSRPSVCNAMEVLLVHEDKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYV
LAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPM
GLKELTSYKYVVTGDGQIRE

Sequences:

>Translated_420_residues
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARG
IREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
KKGLETTTIHPNVIQLVEDTSHESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
SIINNAKTSRPSVCNAMEVLLVHEDKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYV
LAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPM
GLKELTSYKYVVTGDGQIRE
>Mature_420_residues
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARG
IREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
KKGLETTTIHPNVIQLVEDTSHESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
SIINNAKTSRPSVCNAMEVLLVHEDKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYV
LAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPM
GLKELTSYKYVVTGDGQIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=33.4928229665072, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=33.4928229665072, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=45.7420924574209, Blast_Score=352, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17569969, Length=404, Percent_Identity=33.4158415841584, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17569967, Length=404, Percent_Identity=33.4158415841584, Blast_Score=231, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=38.568129330254, Blast_Score=269, Evalue=6e-73,
Organism=Drosophila melanogaster, GI21357643, Length=386, Percent_Identity=36.2694300518135, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45238; Mature: 45238

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHEEEEE
ESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTALKKGLETTTIHPNVIQLVEDT
ECCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCC
SHESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
CCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHH
SIINNAKTSRPSVCNAMEVLLVHEDKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQ
HHHHCCCCCCCCHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
FVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTD
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECC
QVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPMGLKELTSYKYVVTGDGQIRE
CCCCEEEEEECCCEECCCCCCCCCEECCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC
>Mature Secondary Structure
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHEEEEE
ESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTALKKGLETTTIHPNVIQLVEDT
ECCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCC
SHESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
CCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHH
SIINNAKTSRPSVCNAMEVLLVHEDKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQ
HHHHCCCCCCCCHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
FVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTD
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECC
QVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPMGLKELTSYKYVVTGDGQIRE
CCCCEEEEEECCCEECCCCCCCCCEECCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA