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The map label for this gene is coaE [H]

Identifier: 169833367

GI number: 169833367

Start: 988765

End: 989370

Strand: Direct

Name: coaE [H]

Synonym: SPH_1072

Alternate gene names: 169833367

Gene position: 988765-989370 (Clockwise)

Preceding gene: 169833803

Following gene: 169832907

Centisome position: 44.03

GC content: 44.55

Gene sequence:

>606_bases
ATGAGAAAAATCATCGGAATCACTGGGGGAATTGCCTCTGGTAAGTCAACTGTGACAAATTTTCTAAGACAGCAAGGCTT
TCAAGTAGTGGATGCCGACGCAGTCGTCCACCAACTACAGAAACCTGGTGGTCGTCTGTTTGAGGCTCTAGTACAGCACT
TTGGGCAAGAAATCATTCTTGAAAACGGAGAACTCAATCGCCCTCTCCTAGCTAGTCTCATCTTTTCAAATCCTGAAGAG
CAAAAATGGTCTAAGCAAATTCAAGGGGAGATTATCCGTGAGGAACTGGCTACTTTGAGAGAACAGTTGGCTCAGACAGA
AGAGATTTTCTTCATGGATATTCCCCTACTTTTTGAGCAGGACTACAGCGATTGGTTTGCTGAGACTTGGTTGGTCTATG
TGGACCGAGATGCCCAAGTAGAACGCTTAATGAAAAGGGACCAGTTGTCCAAAGATGAAGCTGAGTCTCGTCTGGCAGCC
CAGTGGCCTTTAGAAAAAAAGAAAGATTTGGCCAGCCAGGTTCTTGATAATAATGGCAATCAGAACCAGCTTCTTAATCA
AGTGCATATCCTTCTTGAGGGAGGTAGGCAAGATGACAGAGATTAA

Upstream 100 bases:

>100_bases
AGACTGGTCAAGAATGTGTACGCTGTGGTACCATCATTGAGAAAATTCAACTAGGCGGACGAAGCACCCACTTTTGTCCA
AACTGTCAAAGGAGGGACTG

Downstream 100 bases:

>100_bases
CTGGAAGGATAATCTGCGTATTGCCTGGTTTGGTAATTTTCTGACAGGAGCCAGTATTTCTTTGGTTGTACCTTTTATGC
CCATCTTCGTGGAAAATCTA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIILENGELNRPLLASLIFSNPEE
QKWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAA
QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD

Sequences:

>Translated_201_residues
MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIILENGELNRPLLASLIFSNPEE
QKWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAA
QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD
>Mature_201_residues
MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIILENGELNRPLLASLIFSNPEE
QKWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAA
QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=191, Percent_Identity=39.2670157068063, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI191252795, Length=191, Percent_Identity=39.2670157068063, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI110227607, Length=162, Percent_Identity=32.0987654320988, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI205277394, Length=162, Percent_Identity=32.0987654320988, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI110227605, Length=162, Percent_Identity=32.0987654320988, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI110227603, Length=162, Percent_Identity=32.0987654320988, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI110227601, Length=162, Percent_Identity=32.0987654320988, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1786292, Length=188, Percent_Identity=34.5744680851064, Blast_Score=114, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17554944, Length=193, Percent_Identity=40.4145077720207, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25143409, Length=160, Percent_Identity=30, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320402, Length=193, Percent_Identity=33.160621761658, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644728, Length=179, Percent_Identity=35.7541899441341, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24658602, Length=164, Percent_Identity=36.5853658536585, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 23089; Mature: 23089

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIIL
CCCEEEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
ENGELNRPLLASLIFSNPEEQKWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQ
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHC
DYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAAQWPLEKKKDLASQVLDNNGN
CHHHHHHHHHHHEECCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
QNQLLNQVHILLEGGRQDDRD
HHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEALVQHFGQEIIL
CCCEEEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
ENGELNRPLLASLIFSNPEEQKWSKQIQGEIIREELATLREQLAQTEEIFFMDIPLLFEQ
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHC
DYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAAQWPLEKKKDLASQVLDNNGN
CHHHHHHHHHHHEECCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
QNQLLNQVHILLEGGRQDDRD
HHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]