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The map label for this gene is insK [H]

Identifier: 169832885

GI number: 169832885

Start: 1342146

End: 1342985

Strand: Direct

Name: insK [H]

Synonym: SPH_1455

Alternate gene names: 169832885

Gene position: 1342146-1342985 (Clockwise)

Preceding gene: 169833398

Following gene: 169833760

Centisome position: 59.77

GC content: 38.93

Gene sequence:

>840_bases
ATGGCTTCAGGAGGATTTCAATTAGATTTACTTCTTGAAACAGCACGTTTAGCTCGCTCGACTTACTACTATCAGTTGAA
GGGACTAGGTGGGCTTGACAAAGATAAAGATCTTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATG
GCTATCGTAGAGTTACTCTTGAACTAAGAAATCGTGGTTTTGTGGTGAATCATAAGAAAGTTCAACGTCTGATGAAAGTT
CTTGGTTTAACAGCTCGAATTCGTCGGAAACGAAAGTATTCCTCCTACCAAGGAGAGATTGGCAAGAAAGCAGAGAATCT
CATTCAACGCCAGTTCGAAGCATCGAGACCAATGGAAAAGTGCTATACGGATGTGACAGAGTTTGCCATTCCAGCAAGCA
GTCAAAAGCTCTATTTATCGCCAGTTTTAGATGGCTTTAACAGCGAAATTATCGCCTATAATCTTTCAACTTCACCAAAC
TTAGAACAAGGGAAAGCTATGTTAAACCAGGCCTTTACAGAGAAACATTATGAGAATACCATTCTCCATAGCGATCAAGG
CTGGCAATACCAACACGATTCTTATCATCGGTTCCTAGAGAGTAAGGGAATTCAAGCATCCATGTCACGCAAGGGAAACA
GCCCAGACAATGGCATGATGGAGTCCTTCTTTGGCATTTTGAAATCCGAAATGTTTTATGGTTATGAGAAGACATTTCAG
TCGCTTAATCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGAATTAAGATAAAACTAAAAGG
ACTTAGTCCTGTGCAATACAGAACTAAATCCTTCGGATAA

Upstream 100 bases:

>100_bases
ATGAACGCTTACGTACCGAGGTGGCTTACTTAAAAAAGTTAAAAGAGCTGGAAGACAGGGACGAAGCCCTAGAGCGAGAA
AGGCAGAGATAGTTAGAGAA

Downstream 100 bases:

>100_bases
ATTAATTGTCTAACTTTTGGGGGTCAGTACAAGATTGAACTGCTTTTACGGATTCAGATAAAATAACTTTAAAATATAGA
AAATATATATTGGCTGTAAC

Product: integrase core subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MASGGFQLDLLLETARLARSTYYYQLKGLGGLDKDKDLKAEIQAIFTEHKGNYGYRRVTLELRNRGFVVNHKKVQRLMKV
LGLTARIRRKRKYSSYQGEIGKKAENLIQRQFEASRPMEKCYTDVTEFAIPASSQKLYLSPVLDGFNSEIIAYNLSTSPN
LEQGKAMLNQAFTEKHYENTILHSDQGWQYQHDSYHRFLESKGIQASMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFQ
SLNQLEQAIVDYIDYYNNKRIKIKLKGLSPVQYRTKSFG

Sequences:

>Translated_279_residues
MASGGFQLDLLLETARLARSTYYYQLKGLGGLDKDKDLKAEIQAIFTEHKGNYGYRRVTLELRNRGFVVNHKKVQRLMKV
LGLTARIRRKRKYSSYQGEIGKKAENLIQRQFEASRPMEKCYTDVTEFAIPASSQKLYLSPVLDGFNSEIIAYNLSTSPN
LEQGKAMLNQAFTEKHYENTILHSDQGWQYQHDSYHRFLESKGIQASMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFQ
SLNQLEQAIVDYIDYYNNKRIKIKLKGLSPVQYRTKSFG
>Mature_278_residues
ASGGFQLDLLLETARLARSTYYYQLKGLGGLDKDKDLKAEIQAIFTEHKGNYGYRRVTLELRNRGFVVNHKKVQRLMKVL
GLTARIRRKRKYSSYQGEIGKKAENLIQRQFEASRPMEKCYTDVTEFAIPASSQKLYLSPVLDGFNSEIIAYNLSTSPNL
EQGKAMLNQAFTEKHYENTILHSDQGWQYQHDSYHRFLESKGIQASMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFQS
LNQLEQAIVDYIDYYNNKRIKIKLKGLSPVQYRTKSFG

Specific function: Involved in the transposition of the insertion sequence IS150 [H]

COG id: COG2801

COG function: function code L; Transposase and inactivated derivatives

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 integrase catalytic domain [H]

Homologues:

Organism=Homo sapiens, GI310129419, Length=255, Percent_Identity=29.8039215686275, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1789981, Length=274, Percent_Identity=51.4598540145985, Blast_Score=280, Evalue=8e-77,
Organism=Escherichia coli, GI1788405, Length=280, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787263, Length=280, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786753, Length=280, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786570, Length=280, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786490, Length=280, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001584
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00665 rve [H]

EC number: NA

Molecular weight: Translated: 32281; Mature: 32150

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50994 INTEGRASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGGFQLDLLLETARLARSTYYYQLKGLGGLDKDKDLKAEIQAIFTEHKGNYGYRRVTL
CCCCCEEHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
ELRNRGFVVNHKKVQRLMKVLGLTARIRRKRKYSSYQGEIGKKAENLIQRQFEASRPMEK
EECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
CYTDVTEFAIPASSQKLYLSPVLDGFNSEIIAYNLSTSPNLEQGKAMLNQAFTEKHYENT
HHHHHHHHCCCCCCCEEEEHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
ILHSDQGWQYQHDSYHRFLESKGIQASMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFQ
EEECCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SLNQLEQAIVDYIDYYNNKRIKIKLKGLSPVQYRTKSFG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure 
ASGGFQLDLLLETARLARSTYYYQLKGLGGLDKDKDLKAEIQAIFTEHKGNYGYRRVTL
CCCCEEHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
ELRNRGFVVNHKKVQRLMKVLGLTARIRRKRKYSSYQGEIGKKAENLIQRQFEASRPMEK
EECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
CYTDVTEFAIPASSQKLYLSPVLDGFNSEIIAYNLSTSPNLEQGKAMLNQAFTEKHYENT
HHHHHHHHCCCCCCCEEEEHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
ILHSDQGWQYQHDSYHRFLESKGIQASMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFQ
EEECCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SLNQLEQAIVDYIDYYNNKRIKIKLKGLSPVQYRTKSFG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841644; 2541046; 8041620; 9278503 [H]