| Definition | Streptococcus pneumoniae Hungary19A-6, complete genome. |
|---|---|
| Accession | NC_010380 |
| Length | 2,245,615 |
Click here to switch to the map view.
The map label for this gene is pcrA [H]
Identifier: 169832763
GI number: 169832763
Start: 1082521
End: 1084812
Strand: Direct
Name: pcrA [H]
Synonym: SPH_1179
Alternate gene names: 169832763
Gene position: 1082521-1084812 (Clockwise)
Preceding gene: 169833677
Following gene: 169834408
Centisome position: 48.21
GC content: 43.02
Gene sequence:
>2292_bases ATGAACGCATTATTAAATGGAATGAATGACCGTCAGGCTGAGGCGGTGCAAACGACAGAAGGTCCCTTGCTAATCATGGC AGGGGCTGGTTCTGGAAAGACTCGTGTTTTAACCCACCGTATCGCTTATTTGATTGATGAAAAGCTGGTCAATCCTTGGA ATATCTTGGCCATTACCTTTACCAACAAGGCTGCGCGTGAGATGAAAGAGCGTGCTTATAGCCTCAATCCAGCTACTCAG GACTGTCTGATTGCGACCTTCCACTCCATGTGTGTGCGTATTTTGCGTCGCGATGCGGACCATATTGGCTACAATCGTAA TTTTACAATTGTGGATCCTGGTGAACAGCGAACGCTCATGAAACGTATTCTCAAACAGTTGAACTTGGATCCTAAAAAAT GGAATGAACGAACTATTTTGGGGACCATTTCCAATGCTAAGAATGATTTGATTGATGATGTTGCTTATGCTGCCCAAGCT GGCGATATGTATACGCAAATTGTGGCCCAGTGTTATACAACCTATCAAAAAGAACTTCGTCAGTCTGAATCCGTTGACTT TGATGATTTGATTATGCTGACCTTGCGTCTCTTTGATCAAAATCCTGATGTTTTGACCTACTACCAGCAAAAATTCCAAT ACATCCACGTTGATGAGTACCAAGATACCAACCACGCTCAGTACCAATTGGTCAAACTCTTGGCTTCCCGTTTTAAAAAT ATCTGTGTGGTTGGGGATGCGGACCAGTCTATCTACGGTTGGCGTGGTGCTGATATGCAGAATATCTTGGACTTTGAAAA GGATTACCCCAAAGCCAAGGTTGTTTTGTTGGAGGAAAATTACCGCTCAACCAAAACCATTCTCCAAGCGGCCAACGAGG TTATTAAAAATAATAAAAATCGCCGTCCTAAAAATCTCTGGACTCAAAACGCTGATGGGGAGCAAATCGTTTACTATCGT GCCGATGATGAGCTGGATGAGGCTGTATTTGTAGTCAGAACCATCGATGAACTTAGTCGCAGTCAAAACTTCCTTCATAA GGATTTTGCAGTTCTCTATCGGACTAATGCCCAGTCCCGTACAATTGAGGAAGCCCTGCTCAAGTCTAACATTCCTTATA CCATGGTTGGTGGAACCAAATTCTACAGCCGTAAGGAAATTCGCGATATTATTGCTTATCTCAACCTTATTGCTAATTTG AGTGACAATATTAGTTTTGAGCGTATTATCAACGAGCCTAAACGTGGAATTGGTCTAGGTACAGTTGAGAAAATCCGTGA TTTTGCAAATTTGCAAAATATGTCTATGCTGGATGCTTCTGCTAATATTATGTTGTCTGGTATCAAGGGTAAGGCAGCCC AATCTATCTGGGATTTTGCCAATATGATGCTTGATTTGCGGGAGCAGCTAGACCACTTAAGCATTACAGAGTTGGTTGAG TCCGTCCTAGAAAAAACAGGTTATGTCGATATTCTTAACGCCCAAGCGACTCTAGAAAGCAAGGCAAGGGTTGAAAATAT CGAAGAGTTTCTTTCTGTTACGAAGAACTTTGATGACACCACTGATGTGACAGAAGAGGAAACTGGTCTGGACAAACTGA GTCGTTTCTTAAATGACTTGGCTTTGATTGCTGACACAGATTCAGGTAGTCAGGAGACATCAGAAGTGACCTTGATGACC CTGCATGCTGCCAAAGGTCTCGAATTTCCAGTTGTCTTTTTGATTGGGATGGAAGAAAATGTCTTTCCACTTAGTCGTGC GACTGAAGATCCAGATGAATTAGAAGAAGAGCGCCGTCTAGCCTATGTAGGTATCACGCGTGCAGAGAAAATTCTCTATC TGACCAATGCCAACTCACGCTTGCTTTTTGGTCGTACCAATTATAACCGTCCGACTCGTTTTATTAACGAAATCAGTTCA GACTTGCTTGAGTATCAAGGTCTGGCTCGTCCTGCAAATACAAGCTTTAAGGCATCATATAGCAGTGGTAGTATTTCCTT TGGTCAAGGTATGAGTTTGGCTCAGGCTCTTCAAGACCGTAAACGCGGTGCTGCCCCAAAATCAATCCAGTCAAGCGGTC TTCCATTTGGTCAATTTACAGCTGGCGCAAAATCAGCATCTAGCGAGGCAAATTGGTCCATTGGTGACATTGCTCTCCAC AAGAAATGGGGAGAGGGAACCGTTCTGGAAGTTTCAGGTAGCGGTGCTAGGCAGGAATTGAAAATCAATTTCCCAGAAGT AGGTTTGAAAAAACTTTTAGCCAGTGTGGCTCCAATTGAGAAAAAAATCTAA
Upstream 100 bases:
>100_bases TAGTTTCAATCCACTATATTTTGCTACTCCCCGTAAAGTTTCTATTTTCCCTGATTTCTGATATAATAGAAATATTGACT TCAAGAGTAAGGAAGAGAAG
Downstream 100 bases:
>100_bases TTTTCCATCCTTCTCACGAATAATAAAGTGAGGAGGATTTTTATGTACAGTATTTCATTCCAAGAAGATTCACTATTACC AAGAGAAAGGCTGGCCAAGG
Product: ATP-dependent DNA helicase PcrA
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 763; Mature: 763
Protein sequence:
>763_residues MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQ DCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA GDMYTQIVAQCYTTYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYR ADDELDEAVFVVRTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANL SDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMT LHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISS DLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKSASSEANWSIGDIALH KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI
Sequences:
>Translated_763_residues MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQ DCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA GDMYTQIVAQCYTTYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYR ADDELDEAVFVVRTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANL SDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMT LHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISS DLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKSASSEANWSIGDIALH KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI >Mature_763_residues MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQ DCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA GDMYTQIVAQCYTTYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYR ADDELDEAVFVVRTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANL SDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMT LHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISS DLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKSASSEANWSIGDIALH KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI
Specific function: Essential helicase [H]
COG id: COG0210
COG function: function code L; Superfamily I DNA and RNA helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]
Homologues:
Organism=Escherichia coli, GI2367296, Length=761, Percent_Identity=38.2391590013141, Blast_Score=513, Evalue=1e-146, Organism=Escherichia coli, GI48994965, Length=645, Percent_Identity=38.4496124031008, Blast_Score=410, Evalue=1e-115, Organism=Escherichia coli, GI1787196, Length=347, Percent_Identity=24.7838616714697, Blast_Score=85, Evalue=2e-17, Organism=Saccharomyces cerevisiae, GI6322369, Length=727, Percent_Identity=29.8486932599725, Blast_Score=234, Evalue=4e-62, Organism=Saccharomyces cerevisiae, GI6324477, Length=672, Percent_Identity=24.2559523809524, Blast_Score=124, Evalue=6e-29,
Paralogues:
None
Copy number: 3000 [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005751 - InterPro: IPR013986 - InterPro: IPR014017 - InterPro: IPR000212 - InterPro: IPR014016 [H]
Pfam domain/function: PF00580 UvrD-helicase [H]
EC number: =3.6.4.12 [H]
Molecular weight: Translated: 86024; Mature: 86024
Theoretical pI: Translated: 5.27; Mature: 5.27
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITF CCCHHCCCCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEE TNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLM CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCEEEECCCHHHHHH KRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQAGDMYTQIVAQCYTTYQKELR HHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH QSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN HHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCC ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKN EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCC RRPKNLWTQNADGEQIVYYRADDELDEAVFVVRTIDELSRSQNFLHKDFAVLYRTNAQSR CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHH TIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANLSDNISFERIINEPKRGIGLG HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC TVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE HHHHHHHHHHHCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDL HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHH ALIADTDSGSQETSEVTLMTLHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRL EEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCE AYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISSDLLEYQGLARPANTSFKASY EEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEC SSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKSASSEANWSIGDIALH CCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCCCCCCCCCCEEEEE KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI EECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCHHHCC >Mature Secondary Structure MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITF CCCHHCCCCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEE TNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLM CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCEEEECCCHHHHHH KRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQAGDMYTQIVAQCYTTYQKELR HHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH QSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN HHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCC ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKN EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCC RRPKNLWTQNADGEQIVYYRADDELDEAVFVVRTIDELSRSQNFLHKDFAVLYRTNAQSR CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHH TIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANLSDNISFERIINEPKRGIGLG HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC TVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE HHHHHHHHHHHCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDL HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHH ALIADTDSGSQETSEVTLMTLHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRL EEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCE AYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISSDLLEYQGLARPANTSFKASY EEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEC SSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKSASSEANWSIGDIALH CCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCCCCCCCCCCEEEEE KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI EECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA