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The map label for this gene is vraR [H]

Identifier: 169825087

GI number: 169825087

Start: 1534205

End: 1534831

Strand: Direct

Name: vraR [H]

Synonym: FMG_1390

Alternate gene names: 169825087

Gene position: 1534205-1534831 (Clockwise)

Preceding gene: 169825086

Following gene: 169825101

Centisome position: 85.35

GC content: 36.04

Gene sequence:

>627_bases
ATGACCTATAAAATAATGATTGTAGATGATCAATTCGTATCTCGTGAAATGTTTAGACTAAATATCAACCAATGTCCTGA
TTATGAAGTTGTCTACTCTGTAGATACCGCCATGTTTGCCGACACTTACGTACTAAATAAAAAAATCGACCTTGTAATAA
TGGATATACTTATGAAGGACGGATCAAATGGCCTCGACGCTGCAGAAAAAATAAAAAAATTAAAACCTGAAATAAAGATT
ATTGCAGTTACAAGCATGCCAGAAGTATCTTGGATGAATAGGGCAAAAGAAATTGGAATAGATAGTTTTTGGTACAAAGA
AATATCAAAAGAAGAAATTTTAGAAATAATCCAAAGAACTTTGGCTGGTGAATCCATCTATCCTTTAGAAACACCTGAGG
TAAAACTTGGCATGGCCAAATCAACTGAACTTACACCTAGAGAAATAGAAGTTCTCCGCCTACTAACCACAGGTGCAGGC
AATGACCAAATAGCAGAAGAGCTTGGGATTTCGCTAAACACTGTAAAAACCCACATTAAGCACATGCTTGATAAAACCGA
ATTTACAAGCCGCACCCAACTTGCAATCCAAGCTAGAATCACAGGATTTGTAATAGAAGACAAGTAG

Upstream 100 bases:

>100_bases
AAAAATATCCGCCAAAGTATCGAAAATTGTGGTGGCAAAATGGAAATTAATTTGGATTCAAATTTCACTTTAATCCTGTC
CTGGCCAAAAGGAGTAAACT

Downstream 100 bases:

>100_bases
TAAATTGTAAAAAAAGTGATGTTGCAAAATAGATAAACCTATTCTGCACATCACTTTTTTCGTATCGGATCAAAGCATTA
AATCCTTTTAATTTTTTAGG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTYKIMIVDDQFVSREMFRLNINQCPDYEVVYSVDTAMFADTYVLNKKIDLVIMDILMKDGSNGLDAAEKIKKLKPEIKI
IAVTSMPEVSWMNRAKEIGIDSFWYKEISKEEILEIIQRTLAGESIYPLETPEVKLGMAKSTELTPREIEVLRLLTTGAG
NDQIAEELGISLNTVKTHIKHMLDKTEFTSRTQLAIQARITGFVIEDK

Sequences:

>Translated_208_residues
MTYKIMIVDDQFVSREMFRLNINQCPDYEVVYSVDTAMFADTYVLNKKIDLVIMDILMKDGSNGLDAAEKIKKLKPEIKI
IAVTSMPEVSWMNRAKEIGIDSFWYKEISKEEILEIIQRTLAGESIYPLETPEVKLGMAKSTELTPREIEVLRLLTTGAG
NDQIAEELGISLNTVKTHIKHMLDKTEFTSRTQLAIQARITGFVIEDK
>Mature_207_residues
TYKIMIVDDQFVSREMFRLNINQCPDYEVVYSVDTAMFADTYVLNKKIDLVIMDILMKDGSNGLDAAEKIKKLKPEIKII
AVTSMPEVSWMNRAKEIGIDSFWYKEISKEEILEIIQRTLAGESIYPLETPEVKLGMAKSTELTPREIEVLRLLTTGAGN
DQIAEELGISLNTVKTHIKHMLDKTEFTSRTQLAIQARITGFVIEDK

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786747, Length=202, Percent_Identity=25.2475247524752, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790102, Length=191, Percent_Identity=24.6073298429319, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23711; Mature: 23580

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYKIMIVDDQFVSREMFRLNINQCPDYEVVYSVDTAMFADTYVLNKKIDLVIMDILMKD
CEEEEEEECCHHHHHHHHEEECCCCCCEEEEEEECHHHHHHHHEECCCHHHHEEEHHHHC
GSNGLDAAEKIKKLKPEIKIIAVTSMPEVSWMNRAKEIGIDSFWYKEISKEEILEIIQRT
CCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHH
LAGESIYPLETPEVKLGMAKSTELTPREIEVLRLLTTGAGNDQIAEELGISLNTVKTHIK
HCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHEECCCCCCHHHHHHHCCCHHHHHHHHH
HMLDKTEFTSRTQLAIQARITGFVIEDK
HHHHHHHCCCHHHEEEEEEEEEEEEECC
>Mature Secondary Structure 
TYKIMIVDDQFVSREMFRLNINQCPDYEVVYSVDTAMFADTYVLNKKIDLVIMDILMKD
EEEEEEECCHHHHHHHHEEECCCCCCEEEEEEECHHHHHHHHEECCCHHHHEEEHHHHC
GSNGLDAAEKIKKLKPEIKIIAVTSMPEVSWMNRAKEIGIDSFWYKEISKEEILEIIQRT
CCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHH
LAGESIYPLETPEVKLGMAKSTELTPREIEVLRLLTTGAGNDQIAEELGISLNTVKTHIK
HCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHEECCCCCCHHHHHHHCCCHHHHHHHHH
HMLDKTEFTSRTQLAIQARITGFVIEDK
HHHHHHHCCCHHHEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]