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The map label for this gene is glmS [H]

Identifier: 169824913

GI number: 169824913

Start: 1324387

End: 1326207

Strand: Direct

Name: glmS [H]

Synonym: FMG_1216

Alternate gene names: 169824913

Gene position: 1324387-1326207 (Clockwise)

Preceding gene: 169824908

Following gene: 169824918

Centisome position: 73.68

GC content: 33.33

Gene sequence:

>1821_bases
ATGTGCGGAATAGTATGTTATAACGGCGAAAAATCAGCCGTAGAAATCATATTAAACGGATTAAAATCTCTGGAATACAG
AGGATATGATTCAAGCGGTATTTCTGTCGTAACAGACAAAATCGAAACAGTAAAAAGAAAAGGAAAATTACAAAATTTAA
TAGATTCTATCGATGAAATTGATAACAATGCAAGTATTGGAATTGGTCACATCAGATGGGCAACTCACGGCGAACCTAAT
GAAATAAATGCCCACCCTCAAGTAAGTGAAGATGGCAAATTCTCAGTTGTACACAACGGTATTATCGAAAATTACAAAGA
ATTAAAAAAAGAAATGGAAGATAATGGCTACACTTTTAAATCAACTACTGACACAGAAGTTGTGGTTGCTTTGATTAGCC
ACTATTACAAAGATAATTTGTTGGAAGCAGTAAAATCTACAATCAATAGATTAAAAGGAGCTTATGCGTTAGGAATTGTT
TCAGAATATGAAAAAGACAAACTAATTGCAGTGAGAAAAGAATCTCCATTGATTATGGGTAAATGTGATGATGGAATAAT
CTTAGCGAGTGATATTCCTTCTGTTTTAAAGTATACAAGAGACATTGTGTATTTGGAAAATGGAGATGTCGTAGAGATAG
ATAAGAAAAATTACACAATATACGACAAAGACTTCGCAAAAGTTGATCGTGAAGTTAAAACTGTTGACATGACAATTGAT
CAAGCTAGTAAAGGCGGATACGATCATTTTATGTTAAAAGAAATTCACGAACAGCCAGAAGTTGTGAAAAAGACTTTGGA
AGTTAATCTAAATAATAATGTAATAGATTTTGCAGAAAACTCACTAACTGAAGAAGAATTATCGAAAATCAACAAAATTT
ATATCGTTGCATGTGGTACAGCATTCCATGCAGGTGAAGTCGGTAAAGTTGCAATCGAAAAATTGGCAAAAATTCCTGTA
ATTACTGATATCGCATCTGAATTTAGATACAATGATCCATTTATCGATGAAAATACTCTAGTGATTTTGATTTCTCAATC
AGGAGAAACTGCTGATACATTAGCAGCTCTTAGAGAGTCCAAAAATAAAGGCGCAAAAATCTTAGCAGTTACAAACGTAG
TTGGTTCATCAATCGCAAGAGAAGCTGACAAAGTCATCTACACTTTGGCAGGCCCAGAAATCGCAGTAGCCAGCACTAAA
GCATACATTTCACAATTAGTTACAATGATTATGTTGGCTTTGGATTTCGCAAAGAAATTAGGCAGAATTGAAGATTCTGA
ATATTCAAAATACATCGAAGAATTAAAAACAATGCCTAAAAAAATTGATGAAACATTAAAATCAGAACCTATAACTGAAA
AAATCGCTGAAGCAATCAAAGATGATAAATCAATGTTTTTCATTGGACGTGGCTTGGACTTTTTGAGTGTAAAAGAAGGA
GCTTTGAAATTAAAGGAAATTTCCTACATTCACACTGAAGCCTTCCCTGCAGGAGAATTAAAACACGGTTCCATCGCTTT
GATCGAACAAAACACTCCAGCATTATCAGTTATTACGCAATCAAAATTAGCTGAAAAGACAATATCAAATGTTCAAGAAG
TTGTGACAAGAGGAGCTAAGGTATTTACAATCACAGTTGAAGGAAATGACAATATGAAAGATTTCTCAGAAGAAATCATC
TTCATTCCTAAAACTTTAGAATTATTGTATCCTATACTTTCAGTAGTTCCCGAACAATTATTGGGATATCACACTTCTTT
GAAAAAAGGATTAGATGTCGATAAACCACGTAACTTAGCGAAATCAGTTACAGTTGAATAA

Upstream 100 bases:

>100_bases
AGCTCTATAGGTAACACAGCCTTAGCATTTAACAAAGTTCAAAAGTAATTTTGAAACAAAAATAATGAAGTGTATCTCTA
AAAAATTTGGAGGTAAATAT

Downstream 100 bases:

>100_bases
AAAATACGGAGTACTCATTATAATGTGAGTACTCCTTTTTTAATGATTAATATTAAATTTTTAAATACATTTTATAGTTC
TAAATTAGGATAAACTTTCA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MCGIVCYNGEKSAVEIILNGLKSLEYRGYDSSGISVVTDKIETVKRKGKLQNLIDSIDEIDNNASIGIGHIRWATHGEPN
EINAHPQVSEDGKFSVVHNGIIENYKELKKEMEDNGYTFKSTTDTEVVVALISHYYKDNLLEAVKSTINRLKGAYALGIV
SEYEKDKLIAVRKESPLIMGKCDDGIILASDIPSVLKYTRDIVYLENGDVVEIDKKNYTIYDKDFAKVDREVKTVDMTID
QASKGGYDHFMLKEIHEQPEVVKKTLEVNLNNNVIDFAENSLTEEELSKINKIYIVACGTAFHAGEVGKVAIEKLAKIPV
ITDIASEFRYNDPFIDENTLVILISQSGETADTLAALRESKNKGAKILAVTNVVGSSIAREADKVIYTLAGPEIAVASTK
AYISQLVTMIMLALDFAKKLGRIEDSEYSKYIEELKTMPKKIDETLKSEPITEKIAEAIKDDKSMFFIGRGLDFLSVKEG
ALKLKEISYIHTEAFPAGELKHGSIALIEQNTPALSVITQSKLAEKTISNVQEVVTRGAKVFTITVEGNDNMKDFSEEII
FIPKTLELLYPILSVVPEQLLGYHTSLKKGLDVDKPRNLAKSVTVE

Sequences:

>Translated_606_residues
MCGIVCYNGEKSAVEIILNGLKSLEYRGYDSSGISVVTDKIETVKRKGKLQNLIDSIDEIDNNASIGIGHIRWATHGEPN
EINAHPQVSEDGKFSVVHNGIIENYKELKKEMEDNGYTFKSTTDTEVVVALISHYYKDNLLEAVKSTINRLKGAYALGIV
SEYEKDKLIAVRKESPLIMGKCDDGIILASDIPSVLKYTRDIVYLENGDVVEIDKKNYTIYDKDFAKVDREVKTVDMTID
QASKGGYDHFMLKEIHEQPEVVKKTLEVNLNNNVIDFAENSLTEEELSKINKIYIVACGTAFHAGEVGKVAIEKLAKIPV
ITDIASEFRYNDPFIDENTLVILISQSGETADTLAALRESKNKGAKILAVTNVVGSSIAREADKVIYTLAGPEIAVASTK
AYISQLVTMIMLALDFAKKLGRIEDSEYSKYIEELKTMPKKIDETLKSEPITEKIAEAIKDDKSMFFIGRGLDFLSVKEG
ALKLKEISYIHTEAFPAGELKHGSIALIEQNTPALSVITQSKLAEKTISNVQEVVTRGAKVFTITVEGNDNMKDFSEEII
FIPKTLELLYPILSVVPEQLLGYHTSLKKGLDVDKPRNLAKSVTVE
>Mature_606_residues
MCGIVCYNGEKSAVEIILNGLKSLEYRGYDSSGISVVTDKIETVKRKGKLQNLIDSIDEIDNNASIGIGHIRWATHGEPN
EINAHPQVSEDGKFSVVHNGIIENYKELKKEMEDNGYTFKSTTDTEVVVALISHYYKDNLLEAVKSTINRLKGAYALGIV
SEYEKDKLIAVRKESPLIMGKCDDGIILASDIPSVLKYTRDIVYLENGDVVEIDKKNYTIYDKDFAKVDREVKTVDMTID
QASKGGYDHFMLKEIHEQPEVVKKTLEVNLNNNVIDFAENSLTEEELSKINKIYIVACGTAFHAGEVGKVAIEKLAKIPV
ITDIASEFRYNDPFIDENTLVILISQSGETADTLAALRESKNKGAKILAVTNVVGSSIAREADKVIYTLAGPEIAVASTK
AYISQLVTMIMLALDFAKKLGRIEDSEYSKYIEELKTMPKKIDETLKSEPITEKIAEAIKDDKSMFFIGRGLDFLSVKEG
ALKLKEISYIHTEAFPAGELKHGSIALIEQNTPALSVITQSKLAEKTISNVQEVVTRGAKVFTITVEGNDNMKDFSEEII
FIPKTLELLYPILSVVPEQLLGYHTSLKKGLDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=683, Percent_Identity=34.9926793557833, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=35.8187134502924, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI29570798, Length=245, Percent_Identity=26.9387755102041, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=44.1176470588235, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI87082251, Length=350, Percent_Identity=24.2857142857143, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788651, Length=201, Percent_Identity=28.8557213930348, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=37.6443418013857, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=37.8190255220418, Blast_Score=278, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=37.8190255220418, Blast_Score=278, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=432, Percent_Identity=36.8055555555556, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=32.7102803738318, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=39.0243902439024, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=36.4963503649635, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24659598, Length=263, Percent_Identity=24.3346007604563, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67223; Mature: 67223

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVCYNGEKSAVEIILNGLKSLEYRGYDSSGISVVTDKIETVKRKGKLQNLIDSIDEI
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DNNASIGIGHIRWATHGEPNEINAHPQVSEDGKFSVVHNGIIENYKELKKEMEDNGYTFK
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEE
STTDTEVVVALISHYYKDNLLEAVKSTINRLKGAYALGIVSEYEKDKLIAVRKESPLIMG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCEEEE
KCDDGIILASDIPSVLKYTRDIVYLENGDVVEIDKKNYTIYDKDFAKVDREVKTVDMTID
ECCCCEEECCCCHHHHHHHCCEEEECCCCEEEECCCCCEEECCHHHHHCCHHEEEEEEEE
QASKGGYDHFMLKEIHEQPEVVKKTLEVNLNNNVIDFAENSLTEEELSKINKIYIVACGT
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEECHHCCCCHHHHHHCCEEEEEEECC
AFHAGEVGKVAIEKLAKIPVITDIASEFRYNDPFIDENTLVILISQSGETADTLAALRES
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHC
KNKGAKILAVTNVVGSSIAREADKVIYTLAGPEIAVASTKAYISQLVTMIMLALDFAKKL
CCCCCEEEEEHHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
GRIEDSEYSKYIEELKTMPKKIDETLKSEPITEKIAEAIKDDKSMFFIGRGLDFLSVKEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCC
ALKLKEISYIHTEAFPAGELKHGSIALIEQNTPALSVITQSKLAEKTISNVQEVVTRGAK
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCE
VFTITVEGNDNMKDFSEEIIFIPKTLELLYPILSVVPEQLLGYHTSLKKGLDVDKPRNLA
EEEEEEECCCCHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
KSVTVE
HHCCCC
>Mature Secondary Structure
MCGIVCYNGEKSAVEIILNGLKSLEYRGYDSSGISVVTDKIETVKRKGKLQNLIDSIDEI
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DNNASIGIGHIRWATHGEPNEINAHPQVSEDGKFSVVHNGIIENYKELKKEMEDNGYTFK
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEE
STTDTEVVVALISHYYKDNLLEAVKSTINRLKGAYALGIVSEYEKDKLIAVRKESPLIMG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCEEEE
KCDDGIILASDIPSVLKYTRDIVYLENGDVVEIDKKNYTIYDKDFAKVDREVKTVDMTID
ECCCCEEECCCCHHHHHHHCCEEEECCCCEEEECCCCCEEECCHHHHHCCHHEEEEEEEE
QASKGGYDHFMLKEIHEQPEVVKKTLEVNLNNNVIDFAENSLTEEELSKINKIYIVACGT
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEECHHCCCCHHHHHHCCEEEEEEECC
AFHAGEVGKVAIEKLAKIPVITDIASEFRYNDPFIDENTLVILISQSGETADTLAALRES
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHC
KNKGAKILAVTNVVGSSIAREADKVIYTLAGPEIAVASTKAYISQLVTMIMLALDFAKKL
CCCCCEEEEEHHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
GRIEDSEYSKYIEELKTMPKKIDETLKSEPITEKIAEAIKDDKSMFFIGRGLDFLSVKEG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCC
ALKLKEISYIHTEAFPAGELKHGSIALIEQNTPALSVITQSKLAEKTISNVQEVVTRGAK
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCE
VFTITVEGNDNMKDFSEEIIFIPKTLELLYPILSVVPEQLLGYHTSLKKGLDVDKPRNLA
EEEEEEECCCCHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
KSVTVE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]